JAK2 V617F and CALR mutations are not mutually exclusive; findings from retrospective analysis of a small patient cohort

British Journal of Haematology

Volumn 167, Issue 2, 2014, Pages 276-278

  Mcgaffin, Gillian ^a   Harper, Kirsteen ^a   Stirling, David ^a   Mclintock, Lorna ^b  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b VICTORIA HOSPITAL   (United Kingdom)

Author keywords

Calreticulin; Calreticulin gene; Exclusive; JAK2; Myeloproliferative

Indexed keywords

CALRETICULIN; JANUS KINASE 2; CALRETICULIN, HUMAN; JAK2 PROTEIN, HUMAN;

AGED; CALR GENE; CASE REPORT; COHORT ANALYSIS; DNA SEQUENCE; EXON; FEMALE; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC IDENTIFICATION; GENETIC SCREENING; HUMAN; JAK2 GENE; LETTER; MOLECULAR CLONING; MOLECULAR DIAGNOSTICS; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; THROMBOCYTHEMIA; GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

AGED; CALRETICULIN; COHORT STUDIES; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; JANUS KINASE 2; MUTATION; RETROSPECTIVE STUDIES; THROMBOCYTHEMIA, ESSENTIAL;

EID: 84908499749     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12969     Document Type: Letter

References (5)

1. Klampfl, T., Gisslinger, H., Harutyunyan, A.S., Nivarthi, H., Rumi, E., Milosevic, J.D., Them, N.C., Berg, T., Gisslinger, B., Pietra, D., Chen, D., Vladimer, G.I., Bagienski, K., Milanesi, C., Casetti, I.C., Sant'Antonio, E., Ferretti, V., Elena, C., Schischlik, F., Cleary, C., Six, M., Schalling, M., Schönegger, A., Bock, C., Malcovati, L., Pascutto, C., Superti-Furga, G., Cazzola, M. & Kralovics, R. (2013) Somatic mutations of calreticulin in myeloproliferative neoplasms. New England Journal of Medicine, 369, 2379-2390.
2. Larsen, T.S., Christensen, J.H., Hasselbalch, H.C. & Palllisgaard, N. (2007) The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders. British Journal of Haematology, 136, 745-751.
3. Lundberg, P., Karow, A., Nienhold, R., Looser, R., Hao-Shen, H., Nissen, I., Girsberger, S., Lehmann, T., Passweg, J., Stern, M., Beisel, C., Kralovics, R. & Skoda, R.C. (2014) Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood, 123, 2220-2228.
4. Nangalia, J., Massie, C.E., Baxter, E.J., Nice, F.L., Gundem, G., Wedge, D.C., Avezov, E., Li, J., Kollmann, K., Kent, D.G., Aziz, A., Godfrey, A.L., Hinton, J., Martincorena, I., Van Loo, P., Jones, A.V., Guglielmelli, P., Tarpey, P., Harding, H.P., Fitzpatrick, J.D., Goudie, C.T., Ortmann, C.A., Loughran, S.J., Raine, K., Jones, D.R., Butler, A.P., Teague, J.W., O'Meara, S., McLaren, S., Bianchi, M., Silber, Y., Dimitropoulou, D., Bloxham, D., Mudie, L., Maddison, M., Robinson, B., Keohane, C., Maclean, C., Hill, K., Orchard, K., Tauro, S., Du, M.Q., Greaves, M., Bowen, D., Huntly, B.J., Harrison, C.N., Cross, N.C., Ron, D., Vannucchi, A.M., Papaemmanuil, E., Campbell, P.J. & Green, A.R. (2013) Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. New England Journal of Medicine, 369, 2391-2405.
5. Tefferi, A., Lasho, T.L., Finke, C.M., Knudson, R.A., Ketterling, R., Hanson, C.H., Maffioli, M., Caramazza, D., Passamonti, F. & Pardanani, A. (2014) CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia, doi: 10.1038/leu.2014.3.