-
1
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005; 352(17):1779-1790. (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
2
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
DOI 10.1016/j.ccr.2005.03.023
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397. (Pubitemid 40544655)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
3
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
DOI 10.1038/nature03546
-
James C, Ugo V, Le Couédic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148. (Pubitemid 40663494)
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le, C.J.-P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
4
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
DOI 10.1016/S0140-6736(05)71142-9
-
Baxter EJ, Scott LM, Campbell PJ, et al. Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061. (Pubitemid 40386783)
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Avis, T.13
Barthorpe, A.14
Bignell, G.15
Blow, M.16
Brackenbury, L.17
Buck, G.18
Clegg, S.19
Clements, J.20
Cole, J.21
Davies, H.22
Edkins, S.23
Gray, K.24
Gorton, M.25
O'Meara, S.26
Halliday, K.27
Harrison, R.28
Haynes, W.29
Hills, K.30
Hunter, C.31
Jones, D.32
Kosmidou, V.33
Laman, R.34
Lugg, R.35
Parker, A.36
Perry, J.37
Petty, R.38
Small, A.39
Solomon, H.40
Stephens, P.41
Stephens, Y.42
Stevens, C.43
Smith, R.44
Tarpey, P.45
Tofts, C.46
Varian, J.47
West, S.48
Widaa, S.49
Bamford, S.50
Butler, A.51
Dawson, E.52
Dicks, E.53
Edwards, K.54
Forbes, S.55
Greenman, C.56
Hinton, J.57
Menzies, A.58
Raine, K.59
Shepherd, R.60
Teague, J.61
Yates, A.62
Wooster, R.63
Futreal, A.64
Stratton, M.65
Green, A.R.66
more..
-
5
-
-
33747199312
-
Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
-
DOI 10.1182/blood-2005-11-009605
-
Kralovics R, Teo SS, Li S, et al. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006;108(4):1377-1380. (Pubitemid 44232040)
-
(2006)
Blood
, vol.108
, Issue.4
, pp. 1377-1380
-
-
Kralovics, R.1
Teo, S.-S.2
Li, S.3
Theocharides, A.4
Buser, A.S.5
Tichelli, A.6
Skoda, R.C.7
-
6
-
-
77950388949
-
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
-
Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood. 2010; 115(10):2003-2007.
-
(2010)
Blood
, vol.115
, Issue.10
, pp. 2003-2007
-
-
Schaub, F.X.1
Looser, R.2
Li, S.3
-
7
-
-
61849118935
-
Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the pre-disposing mutations for JAK2-V617F
-
Schaub FX, Jager R, Looser R, et al. Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the pre-disposing mutations for JAK2-V617F. Blood. 2009;113(9): 2022-2027.
-
(2009)
Blood
, vol.113
, Issue.9
, pp. 2022-2027
-
-
Schaub, F.X.1
Jager, R.2
Looser, R.3
-
8
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
-
(2009)
N Engl J Med
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
-
9
-
-
79960248721
-
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
-
Abdel-Wahab O, Pardanani A, Rampal R, Lasho TL, Levine RL, Tefferi A. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia. 2011; 25(7):1219-1220.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1219-1220
-
-
Abdel-Wahab, O.1
Pardanani, A.2
Rampal, R.3
Lasho, T.L.4
Levine, R.L.5
Tefferi, A.6
-
10
-
-
70450239681
-
Mutations of ASXL1 gene in myeloproliferative neoplasms
-
Carbuccia N, Murati A, Trouplin V, et al. Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia. 2009;23(11):2183-2186.
-
(2009)
Leukemia
, vol.23
, Issue.11
, pp. 2183-2186
-
-
Carbuccia, N.1
Murati, A.2
Trouplin, V.3
-
11
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010; 42(8):722-726.
-
(2010)
Nat Genet
, vol.42
, Issue.8
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
-
12
-
-
80051931772
-
New mutations and pathogenesis of myeloproliferative neoplasms
-
Vainchenker W, Delhommeau F, Constantinescu SN, Bernard OA. New mutations and pathogenesis of myeloproliferative neoplasms. Blood. 2011;118(7):1723-1735.
-
(2011)
Blood
, vol.118
, Issue.7
, pp. 1723-1735
-
-
Vainchenker, W.1
Delhommeau, F.2
Constantinescu, S.N.3
Bernard, O.A.4
-
13
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379- 2390.
-
(2013)
N Engl J Med
, vol.369
, Issue.25
, pp. 2379-2390
-
-
Klampfl, T.1
Gisslinger, H.2
Harutyunyan, A.S.3
-
14
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013; 369(25):2391-2405.
-
(2013)
N Engl J Med
, vol.369
, Issue.25
, pp. 2391-2405
-
-
Nangalia, J.1
Massie, C.E.2
Baxter, E.J.3
-
15
-
-
84899072803
-
Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms
-
published online ahead of print October 22, 2013
-
Tenedini E, Bernardis I, Artusi V, et al. Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms [published online ahead of print October 22, 2013]. Leukemia.
-
Leukemia
-
-
Tenedini, E.1
Bernardis, I.2
Artusi, V.3
-
16
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O, Manshouri T, Patel J, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70(2):447-452.
-
(2010)
Cancer Res
, vol.70
, Issue.2
, pp. 447-452
-
-
Abdel-Wahab, O.1
Manshouri, T.2
Patel, J.3
-
17
-
-
79551542848
-
p53 lesions in leukemic transformation
-
Harutyunyan A, Klampfl T, Cazzola M, Kralovics R. p53 lesions in leukemic transformation. N Engl J Med. 2011;364(5):488-490.
-
(2011)
N Engl J Med
, vol.364
, Issue.5
, pp. 488-490
-
-
Harutyunyan, A.1
Klampfl, T.2
Cazzola, M.3
Kralovics, R.4
-
18
-
-
77958021645
-
LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
-
Pardanani A, Lasho T, Finke C, Oh ST, Gotlib J, Tefferi A. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia. 2010;24(10):1713-1718.
-
(2010)
Leukemia
, vol.24
, Issue.10
, pp. 1713-1718
-
-
Pardanani, A.1
Lasho, T.2
Finke, C.3
Oh, S.T.4
Gotlib, J.5
Tefferi, A.6
-
19
-
-
77954573304
-
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
-
Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A. IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia. 2010;24(6):1146-1151.
-
(2010)
Leukemia
, vol.24
, Issue.6
, pp. 1146-1151
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.M.3
Mai, M.4
McClure, R.F.5
Tefferi, A.6
-
20
-
-
84883742034
-
Mutations and prognosis in primary myelofibrosis
-
Vannucchi AM, Lasho TL, Guglielmelli P, et al. Mutations and prognosis in primary myelofibrosis. Leukemia. 2013;27(9):1861-1869.
-
(2013)
Leukemia
, vol.27
, Issue.9
, pp. 1861-1869
-
-
Vannucchi, A.M.1
Lasho, T.L.2
Guglielmelli, P.3
-
21
-
-
70349256226
-
The 2008 revision of the World Heatlh Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
-
Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Heatlh Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951.
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 937-951
-
-
Vardiman, J.W.1
Thiele, J.2
Arber, D.A.3
-
22
-
-
84879557768
-
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
-
Jutzi JS, Bogeska R, Nikoloski G, et al. MPN patients harbor recurrent truncating mutations in transcription factor NF-E2. J Exp Med. 2013; 210(5):1003-1019.
-
(2013)
J Exp Med
, vol.210
, Issue.5
, pp. 1003-1019
-
-
Jutzi, J.S.1
Bogeska, R.2
Nikoloski, G.3
-
23
-
-
79960396947
-
Novel CUX1 missense mutation in association with 7q- at leukemic transformation of MPN
-
Thoennissen NH, Lasho T, Thoennissen GB, Ogawa S, Tefferi A, Koeffler HP. Novel CUX1 missense mutation in association with 7q- at leukemic transformation of MPN. Am J Hematol. 2011;86(8):703-705.
-
(2011)
Am J Hematol
, vol.86
, Issue.8
, pp. 703-705
-
-
Thoennissen, N.H.1
Lasho, T.2
Thoennissen, G.B.3
Ogawa, S.4
Tefferi, A.5
Koeffler, H.P.6
-
24
-
-
63449099560
-
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
-
Jones AV, Chase A, Silver RT, et al. JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms. Nat Genet. 2009;41(4):446-449.
-
(2009)
Nat Genet
, vol.41
, Issue.4
, pp. 446-449
-
-
Jones, A.V.1
Chase, A.2
Silver, R.T.3
-
25
-
-
84993813872
-
Inherited predisposition to myeloproliferative neoplasms
-
Jones AV, Cross NC. Inherited predisposition to myeloproliferative neoplasms. Ther Adv Hematol. 2013;4(4):237-253.
-
(2013)
Ther Adv Hematol
, vol.4
, Issue.4
, pp. 237-253
-
-
Jones, A.V.1
Cross, N.C.2
-
26
-
-
84887320216
-
A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression
-
Marty C, Lacout C, Droin N, et al. A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression. Leukemia. 2013;27(11):2187-2195.
-
(2013)
Leukemia
, vol.27
, Issue.11
, pp. 2187-2195
-
-
Marty, C.1
Lacout, C.2
Droin, N.3
-
27
-
-
51649087754
-
JAK2 stimulates homologous recombination and genetic instability: Potential implication in the heterogeneity of myeloproliferative disorders
-
Plo I, Nakatake M, Malivert L, et al. JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders. Blood. 2008;112(4):1402-1412.
-
(2008)
Blood
, vol.112
, Issue.4
, pp. 1402-1412
-
-
Plo, I.1
Nakatake, M.2
Malivert, L.3
-
28
-
-
77956578342
-
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
-
Li J, Spensberger D, Ahn JS, et al. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood. 2010;116(9):1528-1538.
-
(2010)
Blood
, vol.116
, Issue.9
, pp. 1528-1538
-
-
Li, J.1
Spensberger, D.2
Ahn, J.S.3
-
29
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence MS, Stojanov P, Polak P, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013; 499(7457):214-218.
-
(2013)
Nature
, vol.499
, Issue.7457
, pp. 214-218
-
-
Lawrence, M.S.1
Stojanov, P.2
Polak, P.3
-
30
-
-
84888219405
-
Clinical and biological implications of driver mutations in myelodysplastic syndromes
-
Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. quiz 3699
-
Papaemmanuil E, Gerstung M, Malcovati L, et al. Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122(22):3616-3627, quiz 3699.
-
(2013)
Blood
, vol.122
, Issue.22
, pp. 3616-3627
-
-
Papaemmanuil, E.1
Gerstung, M.2
Malcovati, L.3
-
31
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
-
(2012)
N Engl J Med
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
Gönen, M.2
Figueroa, M.E.3
-
32
-
-
67349124376
-
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
-
Tefferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia. 2009;23(5): 905-911.
-
(2009)
Leukemia
, vol.23
, Issue.5
, pp. 905-911
-
-
Tefferi, A.1
Pardanani, A.2
Lim, K.H.3
-
33
-
-
79956291339
-
TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
-
Jädersten M, Saft L, Smith A, et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol. 2011;29(15):1971-1979.
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 1971-1979
-
-
Jädersten, M.1
Saft, L.2
Smith, A.3
-
34
-
-
79551504914
-
TP53 mutation and survival in chronic lymphocytic leukemia
-
Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol. 2010;28(29): 4473-4479.
-
(2010)
J Clin Oncol
, vol.28
, Issue.29
, pp. 4473-4479
-
-
Zenz, T.1
Eichhorst, B.2
Busch, R.3
-
35
-
-
84868208186
-
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
-
Busque L, Patel JP, Figueroa ME, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44(11):1179-1181.
-
(2012)
Nat Genet
, vol.44
, Issue.11
, pp. 1179-1181
-
-
Busque, L.1
Patel, J.P.2
Figueroa, M.E.3
|