The role of 1,25-dyhydroxyvitamin D3 in mouse liver ischemia reperfusion injury: Regulation of autophagy through activation of mek/erk signaling and pten/pi3k/akt/mtorc1 signaling

American Journal of Translational Research

Volumn 7, Issue 12, 2015, Pages 2630-2645

  Yang, Jing Hui ^a   Chen, Qi ^b   Tian, Shi Yin ^b   Song, Shao Hua ^a   Liu, Fang ^a   Wang, Quan Xing ^b   Fu, Zhi Ren ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Ischemia reperfusion injury; Vitamin D

Indexed keywords

1,25 TRIHYDROXYCOLECALCIFEROL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BECLIN 1; CATALASE; COLECALCIFEROL DERIVATIVE; GLUTATHIONE; GLUTATHIONE DISULFIDE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; BLOOD SAMPLING; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE TEST; INFLAMMATION; INTRACELLULAR SIGNALING; LIPID PEROXIDATION; LIVER CELL; LIVER FUNCTION; LIVER INJURY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSMISSION ELECTRON MICROSCOPY; TUNEL ASSAY; WESTERN BLOTTING;

EID: 84956948463     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Yang J, Wang X, Song S, Liu F, Fu Z and Wang Q. Near-Term Anti-CD25 Monoclonal Antibody Administration Protects Murine Liver from Ischemia-Reperfusion Injury Due to Reduced Numbers of CD4+ T Cells. PLoS One 2014; 9: e106892.
2. Fondevila C, Busuttil RW and Kupiec-Weglinski JW. Hepatic ischemia/reperfusion injury--a fresh look. Exp Mol Pathol 2003; 74: 86-93.
3. Yu HC, Qin HY, He F, Wang L, Fu W, Liu D, Guo FC, Liang L, Dou KF and Han H. Canonical notch pathway protects hepatocytes from ischemia/ reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology 2011; 54: 979-988.
4. Tewari A, Mahendru V, Sinha A and Bilotta F. Antioxidants: The new frontier for translational research in cerebroprotection. J Anaesthesiol Clin Pharmacol 2014; 30: 160-171.
5. Lum JJ, DeBerardinis RJ and Thompson CB. Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 2005; 6: 439-448.
6. Kim JS, Wang JH and Lemasters JJ. Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+- dependent mitochondrial formation of reactive oxygen species. Am J Physiol Gastrointest Liver Physiol 2012; 302: G723-731.
7. Czaja MJ, Ding WX, Donohue TM Jr., Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A and Yin XM. Functions of autophagy in normal and diseased liver. Autophagy 2013; 9: 1131-1158.
8. Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA Jr., Behrns KE, Leeuwenburgh C and Kim JS. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology 2011; 141: 2188-2199 e2186.
9. Walentowicz-Sadlecka M, Sadlecki P, Walentowicz P and Grabiec M. [The role of vitamin D in the carcinogenesis of breast and ovarian cancer]. Ginekol Pol 2013; 84: 305-308.
10. Korf H, Decallonne B and Mathieu C. Vitamin D for infections. Curr Opin Endocrinol Diabetes Obes 2014; 21: 431-436.
11. Yuk JM, Shin DM, Lee HM, Yang CS, Jin HS, Kim KK, Lee ZW, Lee SH, Kim JM and Jo EK. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009; 6: 231-243.
12. Klotz B, Mentrup B, Regensburger M, Zeck S, Schneidereit J, Schupp N, Linden C, Merz C, Ebert R and Jakob F. 1,25-dihydroxyvitamin D3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity. PLoS One 2012; 7: e29959.
13. Mirzakhani H, Al-Garawi A, Weiss ST and Litonjua AA. Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy 2015; 45: 114-25.
14. Alfawaz HA, Bhat RS, Al-Ayadhi L and El-Ansary AK. Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups. BMC Complement Altern Med 2014; 14: 416.
15. Tao Q, Wang B, Zheng Y, Jiang X, Pan Z and Ren J. Vitamin D Prevents the Intestinal Fibrosis Via Induction of Vitamin D Receptor and Inhibition of Transforming Growth Factor- Beta1/Smad3 Pathway. Dig Dis Sci 2015; 60: 868-75.
16. Yang YH, Li B, Zheng XF, Chen JW, Chen K, Jiang SD and Jiang LS. Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway--implications for the treatment of osteoporosis. Free Radic Biol Med 2014; 77: 10-20.
17. Elias-Miro M, Jimenez-Castro MB, Rodes J and Peralta C. Current knowledge on oxidative stress in hepatic ischemia/reperfusion. Free Radic Res 2013; 47: 555-568.
18. Wang PR, Wang JS, Zhang C, Song XF, Tian N and Kong LY. Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPKmTOR signaling pathway. J Ethnopharmacol 2013; 149: 270-280.
19. Piguet AC and Dufour JF. PI(3)K/PTEN/AKT pathway. J Hepatol 2011; 54: 1317-1319.
20. Tong Y, Huang H and Pan H. Inhibition of MEK/ ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells. Biochem Biophys Res Commun 2015; 456: 86-91.
21. Dong F, Mo Z, Eid W, Courtney KC and Zha X. Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. PLoS One 2014; 9: e113789.
22. Andersen LB, Przybyl L, Haase N, von Versen- Hoynck F, Qadri F, Jorgensen JS, Sorensen GL, Fruekilde P, Poglitsch M, Szijarto I, Gollasch M, Peters J, Muller DN, Christesen HT and Dechend R. Vitamin d depletion aggravates hypertension and target-organ damage. J Am Heart Assoc 2015; 4. pii: e001417.
23. Garcia-Alvarez M, Pineda-Tenor D, Jimenez- Sousa MA, Fernandez-Rodriguez A, Guzman- Fulgencio M and Resino S. Relationship of vitamin D status with advanced liver fibrosis and response to hepatitis C virus therapy: a metaanalysis. Hepatology 2014; 60: 1541-1550.
24. Polidoro L, Properzi G, Marampon F, Gravina GL, Festuccia C, Di Cesare E, Scarsella L, Ciccarelli C, Zani BM and Ferri C. Vitamin D protects human endothelial cells from H(2) O(2) oxidant injury through the Mek/Erk-Sirt1 axis activation. J Cardiovasc Transl Res 2013; 6: 221-231.
25. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts. J Gastroenterol Hepatol 2011; 26 Suppl 1: 173-179.
26. Vucicevic L, Misirkic-Marjanovic M, Paunovic V, Kravic-Stevovic T, Martinovic T, Ciric D, Maric N, Petricevic S, Harhaji-Trajkovic L, Bumbasirevic V and Trajkovic V. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy 2014; 10: 2362-2378.
27. Giron MD, Vilchez JD, Shreeram S, Salto R, Manzano M, Cabrera E, Campos N, Edens NK, Rueda R and Lopez-Pedrosa JM. beta-Hydroxy- beta-Methylbutyrate (HMB) Normalizes Dexamethasone- Induced Autophagy-Lysosomal Pathway in Skeletal Muscle. PLoS One 2015; 10: e0117520.
28. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X and Luo J. Autophagy is a protective response to ethanol neurotoxicity. Autophagy 2012; 8: 1577-1589.
29. Yang Z and Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22: 124-131.
30. Kong B, Wu W, Cheng T, Schlitter AM, Qian C, Bruns P, Jian Z, Jager C, Regel I, Raulefs S, Behler N, Irmler M, Beckers J, Friess H, Erkan M, Siveke JT, Tannapfel A, Hahn SA, Theis FJ, Esposito I, Kleeff J and Michalski CW. A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut 2015. pii: gutjnl-2014-307616.
31. Sun L, Li T, Wei Q, Zhang Y, Jia X, Wan Z and Han L. Upregulation of BNIP3 mediated by ERK/HIF-1alpha pathway induces autophagy and contributes to anoikis resistance of hepatocellular carcinoma cells. Future Oncol 2014; 10: 1387-1398.
32. Kamo N, Ke B, Busuttil RW and Kupiec- Weglinski JW. PTEN-mediated Akt/beta-catenin/ Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology 2013; 57: 289-298.
33. Peyrou M, Bourgoin L, Poher AL, Altirriba J, Maeder C, Caillon A, Fournier M, Montet X, Rohner-Jeanrenaud F and Foti M. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. J Hepatol 2015; 62: 421-429.
34. Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal AM, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral JB, Schrottmaier WC, Thell K, Saferding V, Bluml S and Schabbauer G. Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol 2014; 193: 1717-1727.
35. Zu L, Zheng X, Wang B, Parajuli N, Steenbergen C, Becker LC, Cai ZP. Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by. Am J Physiol Heart Circ Physiol 2011; 300: H2177-86.
36. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J and He B. Vitamin d receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal 2015; 22: 633-650.
37. Sharma K, Goehe RW, Di X, Hicks MA 2nd, Torti SV, Torti FM, Harada H and Gewirtz DA. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy 2014; 10: 2346-2361.
38. Wu S, Zhang YG, Lu R, Xia Y, Zhou D, Petrof EO, Claud EC, Chen D, Chang EB, Carmeliet G and Sun J. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut 2015; 64: 1082-94.