Upregulation of BNIP3 mediated by ERK/HIF-1α pathway induces autophagy and contributes to anoikis resistance of hepatocellular carcinoma cells

Future Oncology

Volumn 10, Issue 8, 2014, Pages 1387-1398

  Sun, Lei ^a   Li, Tao ^a,b   Wei, Qing ^a   Zhang, Ying ^a   Jia, Xiaoqing ^c   Wan, Zhengkun ^a   Han, Lihui ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

anoikis resistance; autophagy; BNIP3; hepatocellular carcinoma; mTOR S6K1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BNIP3; S6 KINASE; BNIP3 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANOIKIS; ARTICLE; ASSAY; AUTOPHAGY; CCK8 ASSAY; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRYPAN BLUE ASSAY; UPREGULATION; WESTERN BLOTTING; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANOIKIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84905276679     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.14.70     Document Type: Article

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