메뉴 건너뛰기




Volumn 10, Issue 12, 2014, Pages 2346-2361

A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089

Author keywords

Autophagy; Cytoprotective; Cytostatic; NSCLC; Radiation

Indexed keywords

ADENYLATE KINASE; PROTEIN P53; SEOCALCITOL; VITAMIN D; VITAMIN D RECEPTOR; ANTINEOPLASTIC AGENT; CALCITRIOL;

EID: 84922143072     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/15548627.2014.993283     Document Type: Article
Times cited : (89)

References (53)
  • 1
    • 84861990751 scopus 로고    scopus 로고
    • Individualized therapy for patients with non-small cell lung cancer: Emerging trends and challenges
    • Langer CJ. Individualized therapy for patients with non-small cell lung cancer: Emerging trends and challenges. Oncology/Hematology 2012; 83: 130-44.
    • (2012) Oncology/Hematology , vol.83 , pp. 130-144
    • Langer, C.J.1
  • 3
    • 84865417560 scopus 로고    scopus 로고
    • Recent advances in non-small cell lung cancer biology and clinical management
    • PMID: 22541616
    • Saintigny P, Burger JA, Recent advances in non-small cell lung cancer biology and clinical management. Discov Med 2012; 13(71): 287-97; PMID: 22541616
    • (2012) Discov Med , vol.13 , Issue.71 , pp. 287-297
    • Saintigny, P.1    Burger, J.A.2
  • 4
    • 84887017268 scopus 로고    scopus 로고
    • Quality of life during chemotherapy in lung cancer patients: Results across different treatment lines
    • PMID: 24091620
    • Wintner LM, Giesinger JM, Zabernigg A, Sztankay M, Meraner V, Pall G, Hilbe W, Holzner B. Quality of life during chemotherapy in lung cancer patients: Results across different treatment lines. Br J Cancer 2013; 109(9): 2301-8; PMID: 24091620; http://dx.doi. org/10.1038/bjc.2013.585
    • (2013) Br J Cancer , vol.109 , Issue.9 , pp. 2301-2308
    • Wintner, L.M.1    Giesinger, J.M.2    Zabernigg, A.3    Sztankay, M.4    Meraner, V.5    Pall, G.6    Hilbe, W.7    Holzner, B.8
  • 5
    • 84892421266 scopus 로고    scopus 로고
    • Feasibility of omitting clinical target volume for limited-disease small cell lung cancer treated with chemotherapy and intensity-modulated radiotherapy
    • PMID: 24410971
    • Cai S, Shi A, Yu R, Zhu G. Feasibility of omitting clinical target volume for limited-disease small cell lung cancer treated with chemotherapy and intensity-modulated radiotherapy. Radiat Oncol 2014; 9: 17; PMID: 24410971; http://dx.doi.org/10.1186/1748- 717X-9-17
    • (2014) Radiat Oncol , vol.9 , pp. 17
    • Cai, S.1    Shi, A.2    Yu, R.3    Zhu, G.4
  • 6
    • 84892845064 scopus 로고    scopus 로고
    • How can we optimize concurrent cheoradiotherapy for inoperable stage III non-small cell lung cancer?
    • PMID: 24373738
    • Bayman N, Blackhall F, McCloskey P, Taylor P, Faivre- Finn C. How can we optimize concurrent cheoradiotherapy for inoperable stage III non-small cell lung cancer? Lung Cancer 2014; n83(2): 117-25; PMID: 24373738; http://dx.doi.org/10.1016/j.lungcan. 2013.11.017
    • (2014) Lung Cancer , vol.N83 , Issue.2 , pp. 117-125
    • Bayman, N.1    Blackhall, F.2    McCloskey, P.3    Taylor, P.4    Faivre- Finn, C.5
  • 7
    • 84863187860 scopus 로고    scopus 로고
    • Factors affecting survival time after recurrence of non-small-cell lung cancer treated with concurrent chemotherapy
    • PMID: 22311092
    • Hamamoto Y, Kataoka M, Nogami N, Kozuki T, Kato Y, Shinohara S, and Shinkai T. Factors affecting survival time after recurrence of non-small-cell lung cancer treated with concurrent chemotherapy. Jpn J Radiol 2012; 30(3): 249-54; PMID: 22311092; http://dx.doi. org/10.1007/s11604-011-0040-9
    • (2012) Jpn J Radiol , vol.30 , Issue.3 , pp. 249-254
    • Hamamoto, Y.1    Kataoka, M.2    Nogami, N.3    Kozuki, T.4    Kato, Y.5    Shinohara, S.6    Shinkai, T.7
  • 8
    • 0032589629 scopus 로고    scopus 로고
    • The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation
    • PMID: 10521924
    • Sundaram S, Gewirtz DA. The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation. Radiat Res 1999; 152(5): 479-86; PMID: 10521924
    • (1999) Radiat Res , vol.152 , Issue.5 , pp. 479-486
    • Sundaram, S.1    Gewirtz, D.A.2
  • 9
    • 0036402060 scopus 로고    scopus 로고
    • Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemotherapy and radiotherapy
    • PMID: 12678720
    • Gewirtz DA, Gupta MS, Sundaram S. Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemotherapy and radiotherapy. Curr Med Chem Anticancer Agents 2002; 2(6): 683-90; PMID: 12678720; http://dx.doi.org/10.2174/1568011023353697
    • (2002) Curr Med Chem Anticancer Agents , vol.2 , Issue.6 , pp. 683-690
    • Gewirtz, D.A.1    Gupta, M.S.2    Sundaram, S.3
  • 10
    • 0038276041 scopus 로고    scopus 로고
    • The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice
    • PMID: 12796405
    • Sundaram S, Sea A, Feldman S, Strawbridge R, Hoopes PJ, Demidenko E, Binderup L, Gewirtz DA. The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. Clin Cancer Res 2003; 9(6): 2350-6; PMID: 12796405
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 2350-2356
    • Sundaram, S.1    Sea, A.2    Feldman, S.3    Strawbridge, R.4    Hoopes, P.J.5    Demidenko, E.6    Binderup, L.7    Gewirtz, D.A.8
  • 11
    • 84859975883 scopus 로고    scopus 로고
    • The role of vitamin D in cancer prevention and treatment
    • PMID: 22525850
    • Krishnan AV, Trump DL, Johnson CS, Feldman D. The role of vitamin D in cancer prevention and treatment. Rheum Dis Clin North Am 2012; 38(1): 161-78; PMID: 22525850; http://dx.doi.org/10.1016/j.rdc.2012. 03.014
    • (2012) Rheum Dis Clin North Am , vol.38 , Issue.1 , pp. 161-178
    • Krishnan, A.V.1    Trump, D.L.2    Johnson, C.S.3    Feldman, D.4
  • 12
    • 79959738378 scopus 로고    scopus 로고
    • Vitamin D and lung cancer
    • PMID: 21702651
    • Ramnath N, Kim S, Christenden PJ. Vitamin D and lung cancer. Expert Rev Respir Med 2011; 5(3): 305-9; PMID: 21702651; http://dx.doi.org/10.1586/ers.11.31
    • (2011) Expert Rev Respir Med , vol.5 , Issue.3 , pp. 305-309
    • Ramnath, N.1    Kim, S.2    Christenden, P.J.3
  • 13
    • 33746604877 scopus 로고    scopus 로고
    • Vitamin D compounds: Clinical development as cancer therapy and prevention agents
    • PMID: 16886663
    • Trump DL, Muindi J, Faikh M, Yu WD, Johnson CS. Vitamin D compounds: Clinical development as cancer therapy and prevention agents. Anticancer Res 2006; 26(4A): 2551-6; PMID: 16886663
    • (2006) Anticancer Res , vol.26 , Issue.4 A , pp. 2551-2556
    • Trump, D.L.1    Muindi, J.2    Faikh, M.3    Yu, W.D.4    Johnson, C.S.5
  • 14
    • 78650577390 scopus 로고    scopus 로고
    • Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer
    • PMID: 20955794
    • Srinivasan M, Parwani VA, Hershberger AP, Lenzner ED, Weissfeld LJ. Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer. J Steroid Biochem Mol Biol 2011; 123(1-2): 30-6; PMID: 20955794
    • (2011) J Steroid Biochem Mol Biol , vol.123 , Issue.1-2 , pp. 30-36
    • Srinivasan, M.1    Parwani, V.A.2    Hershberger, A.P.3    Lenzner, E.D.4    Weissfeld, L.J.5
  • 17
    • 33947512099 scopus 로고    scopus 로고
    • Circulating 25-Hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients
    • PMID: 17290055
    • Zhou W, Heist SR, Liu G, Asomaning K, Neuberg SD, Hollis BW, Wain JC, Lynch TJ, Giovannucci E, Su L et al. Circulating 25-Hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients. J ClinOncol 2007; 25(5): 479-85; PMID: 17290055; http://dx.doi.org/10.1200/JCO.2006.07.5358
    • (2007) J ClinOncol , vol.25 , Issue.5 , pp. 479-485
    • Zhou, W.1    Heist, S.R.2    Liu, G.3    Asomaning, K.4    Neuberg, S.D.5    Hollis, B.W.6    Wain, J.C.7    Lynch, T.J.8    Giovannucci, E.9    Su, L.10
  • 18
    • 84862603409 scopus 로고    scopus 로고
    • Dual functions of autophagy in the response of breast tumor cells to radiation: Cytoprtective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D3
    • PMID: 22498493
    • Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, Fan Z, Gewirtz DA. Dual functions of autophagy in the response of breast tumor cells to radiation: Cytoprtective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D3. Autophagy 2012; 8(5): 739-53; PMID: 22498493; http://dx.doi.org/10.4161/auto. 19313
    • (2012) Autophagy , vol.8 , Issue.5 , pp. 739-753
    • Bristol, M.L.1    Di, X.2    Beckman, M.J.3    Wilson, E.N.4    Henderson, S.C.5    Maiti, A.6    Fan, Z.7    Gewirtz, D.A.8
  • 19
    • 80054038340 scopus 로고    scopus 로고
    • A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D
    • PMID: 21887591
    • Wilson EN, Bristol ML, Di X, Maltese WA, Koterba K, Beckman MJ, Gewirtz DA. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer 2011; 2(5): 272-85; PMID: 21887591; http://dx.doi.org/10.1007/s12672-011- 0081-7
    • (2011) Horm Cancer , vol.2 , Issue.5 , pp. 272-285
    • Wilson, E.N.1    Bristol, M.L.2    Di, X.3    Maltese, W.A.4    Koterba, K.5    Beckman, M.J.6    Gewirtz, D.A.7
  • 20
    • 80052197647 scopus 로고    scopus 로고
    • Vitamin D receptor (VDR)- mediated actions of 1a 25(OH)2vitamin D3: Genomic and non-genomic mechanisms
    • PMID: 21872797
    • Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)- mediated actions of 1a, 25(OH)2vitamin D3: Genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011; 25(4): 543-59; PMID: 21872797
    • (2011) Best Pract Res Clin Endocrinol Metab , vol.25 , Issue.4 , pp. 543-559
    • Haussler, M.R.1    Jurutka, P.W.2    Mizwicki, M.3    Norman, A.W.4
  • 21
    • 33845192397 scopus 로고    scopus 로고
    • Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
    • PMID: 17121925
    • Demasters G, Di X, Newsham I, Shiu R, Gewirtz DA. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Mol Cancer Ther 2006; 5(11): 2786-97; PMID: 17121925
    • (2006) Mol Cancer Ther , vol.5 , Issue.11 , pp. 2786-2797
    • Demasters, G.1    Di X Newsham, I.2    Shiu, R.3    Gewirtz, D.A.4
  • 24
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
    • PMID: 18657518
    • Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 2008; 76(8): 947-57; PMID: 18657518; http://dx.doi.org/10.1016/j.bcp.2008.06.024
    • (2008) Biochem Pharmacol , vol.76 , Issue.8 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 26
    • 84890032905 scopus 로고    scopus 로고
    • Autophagy inhibition radiosensitizes in vitro yet reduces radioresponses in vivo due to deficient immunogenic signaling
    • PMID: 24037090
    • Ko A, Kanehisa A, Martins I, Senovilla L, Chargari C, Dugue D, Marino G, Kepp O, Michaud M, Perfettini JL, et al. Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signaling. Cell Death Differ 2014; 21 (1): 92-9; PMID: 24037090; http://dx.doi.org/10.1038/cdd.2013.124
    • (2014) Cell Death Differ , vol.21 , Issue.1 , pp. 92-99
    • Ko, A.1    Kanehisa, A.2    Martins, I.3    Senovilla, L.4    Chargari, C.5    Dugue, D.6    Marino, G.7    Kepp, O.8    Michaud, M.9    Perfettini, J.L.10
  • 27
    • 0033957264 scopus 로고    scopus 로고
    • P53 gene status modulates the chemosensitivity of non-small cell lung cancer cells
    • PMID: 10644891
    • Lai SL, Pernq RP, Hwang J. p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells. J Biomed Sci 2000; 7(1): 64-70; PMID: 10644891; http://dx.doi.org/10.1007/BF02255920
    • (2000) J Biomed Sci , vol.7 , Issue.1 , pp. 64-70
    • Lai, S.L.1    Pernq, R.P.2    Hwang, J.3
  • 28
    • 79952218385 scopus 로고    scopus 로고
    • Genetic alterations of tumor suppressor ING1 in human non-small cell lung cancer
    • PMID: 21286670
    • Luo ZG, Tang H, Li B, Zhu Z, Ni CR, Zhu MH. Genetic alterations of tumor suppressor ING1 in human non-small cell lung cancer. Oncol Rep 2011; 25(4): 1073-81; PMID: 21286670
    • (2011) Oncol Rep , vol.25 , Issue.4 , pp. 1073-1081
    • Luo, Z.G.1    Tang, H.2    Li, B.3    Zhu, Z.4    Ni, C.R.5    Zhu, M.H.6
  • 29
    • 0034652615 scopus 로고    scopus 로고
    • ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients
    • PMID: 10706117
    • You L, Yang CT, Jablons DM. ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients. Cancer Res 2000; 60(4): 1009-13; PMID: 10706117
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 1009-1013
    • You, L.1    Yang, C.T.2    Jablons, D.M.3
  • 30
    • 57749094952 scopus 로고    scopus 로고
    • Posttranscriptional modulation of iron homeostasis during p53-dependent growth arrest
    • PMID: 18819919
    • Zhang F, Wang W, Tsuji Y, Torti SV, Torti FM. Posttranscriptional modulation of iron homeostasis during p53-dependent growth arrest. J Biol Chem 2008; 283 (49): 33911-8; PMID: 18819919; http://dx.doi.org/10.1074/jbc.M806432200
    • (2008) J Biol Chem , vol.283 , Issue.49 , pp. 33911-33918
    • Zhang, F.1    Wang, W.2    Tsuji, Y.3    Torti, S.V.4    Torti, F.M.5
  • 31
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • PMID: 22436748
    • Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13(4): 251-62; PMID: 22436748; http://dx.doi.org/10.1038/nrm3311
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 32
    • 84862908818 scopus 로고    scopus 로고
    • AMPK and mTOR in cellular energy homeostasis and drug targets
    • PMID: 22017684
    • Inoki K, Kim J, Guan KL. AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol 2012; 52: 381-400; PMID: 22017684; http://dx.doi.org/10.1146/annurevpharmtox- 010611-134537
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 381-400
    • Inoki, K.1    Kim, J.2    Guan, K.L.3
  • 33
    • 84857289515 scopus 로고    scopus 로고
    • Autophagy-dependent senescence in response to DNA damage and chronic apoptosis stress
    • PMID: 22240589
    • Singh K, Matsuyama S, Drazba JA, Almasan A. Autophagy-dependent senescence in response to DNA damage and chronic apoptosis stress. Autophagy 2012; 8(2): 236-51; PMID: 22240589; http://dx.doi.org/10.4161/auto.8.2.18600
    • (2012) Autophagy , vol.8 , Issue.2 , pp. 236-251
    • Singh, K.1    Matsuyama, S.2    Drazba, J.A.3    Almasan, A.4
  • 34
    • 52549124599 scopus 로고    scopus 로고
    • Therapy induced effects in normal tissue
    • PMID: 18709346
    • Van Kaick G, Delorme S. Therapy induced effects in normal tissue. Radiologe 2008; 48(9): 871-80; PMID: 18709346; http://dx.doi.org/10.1007/s00117- 008-1729-3
    • (2008) Radiologe , vol.48 , Issue.9 , pp. 871-880
    • Van Kaick, G.1    Delorme, S.2
  • 35
    • 84867841791 scopus 로고    scopus 로고
    • AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells
    • PMID: 22674626
    • Yang WL, Perillo W, Liou D, Marambaud P, Wang P. AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. J Surg Oncol 2012; 106 (6): 680-8; PMID: 22674626; http://dx.doi.org/10.1002/jso.23184
    • (2012) J Surg Oncol , vol.106 , Issue.6 , pp. 680-688
    • Yang, W.L.1    Perillo, W.2    Liou, D.3    Marambaud, P.4    Wang, P.5
  • 36
    • 84874735362 scopus 로고    scopus 로고
    • The tumor suppressor p53 contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis
    • PMID: 23268708
    • Cheng G, Kong D, Hou X, Liang B, He M, Liang N, Ma S, Liu X. The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis. Cancer Biother Radiopharm 2013; 28(2): 153-9; PMID: 23268708; http://dx.doi. org/10.1089/cbr.2012.1297
    • (2013) Cancer Biother Radiopharm , vol.28 , Issue.2 , pp. 153-159
    • Cheng, G.1    Kong, D.2    Hou, X.3    Liang, B.4    He, M.5    Liang, N.6    Ma, S.7    Liu, X.8
  • 37
    • 84884820821 scopus 로고    scopus 로고
    • Autophagy regulation and its role in cancer
    • PMID: 23811268
    • Lorin S, Hamai A, Mehrpour M, and Codogno P. Autophagy regulation and its role in cancer. Semin Cancer Biol 2013; 28(2): 152-9; PMID: 23811268; http://dx.doi.org/10.1016/j.semcancer.2013.06.007
    • (2013) Semin Cancer Biol , vol.28 , Issue.2 , pp. 152-159
    • Lorin, S.1    Hamai, A.2    Mehrpour, M.3    Codogno, P.4
  • 38
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 2005; 102(23): 8204-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.23 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 39
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2 and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • PMID: 17409411
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2 and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 2007; 67(7): 3043-53; PMID: 17409411; http://dx. doi.org/10.1158/0008-5472.CAN-06-4149
    • (2007) Cancer Res , vol.67 , Issue.7 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    De Stanchina, E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6    Levine, A.J.7
  • 40
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg 13-FIP200 complexes mediate mTOR signaling to autophagy machinery
    • PMID: 19225151
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg 13-FIP200 complexes mediate mTOR signaling to autophagy machinery. Mol Biol Cell 2009; 20(7): 1992-2003; PMID: 19225151; http://dx.doi.org/10.1091/mbc. E08-12-1249
    • (2009) Mol Biol Cell , vol.20 , Issue.7 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6    Kundu, M.7    Kim, D.H.8
  • 41
    • 80052719816 scopus 로고    scopus 로고
    • Up-regulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage- induced cell death
    • PMID: 21475306
    • Gao W, Shen Z, Shang L, and Wang X. Up-regulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage- induced cell death. Cell Death Differ 2011; 18 (10): 1598-607; PMID: 21475306; http://dx.doi.org/10.1038/cdd.2011.33
    • (2011) Cell Death Differ , vol.18 , Issue.10 , pp. 1598-1607
    • Gao, W.1    Shen, Z.2    Shang, L.3    Wang, X.4
  • 42
    • 84864458911 scopus 로고    scopus 로고
    • Research Resource: Diagnostic and Therapeutic potential of nuclear receptor expression in lung cancer
    • PMID: 22700587
    • Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD et al. Research Resource: Diagnostic and Therapeutic potential of nuclear receptor expression in lung cancer. Mol Endocrinol 2012; 26(8): 1443-1454; PMID: 22700587; http://dx.doi.org/10.1210/me.2011-1382
    • (2012) Mol Endocrinol , vol.26 , Issue.8 , pp. 1443-1454
    • Jeong, Y.1    Xie, Y.2    Lee, W.3    Bookout, A.L.4    Girard, L.5    Raso, G.6    Behrens, C.7    Wistuba, I.I.8    Gadzar, A.F.9    Minna, J.D.10
  • 43
    • 79961167902 scopus 로고    scopus 로고
    • Prazosin induces p53-mediated autophagic cell death in H9C2 cells
    • PMID: 21614555
    • Yang YF Wu CC, Chen WP, Chen YL, Su MJ. Prazosin induces p53-mediated autophagic cell death in H9C2 cells. Naunyn Schmiedebergs Arch Pharmacol 2011; 384(2): 209-16; PMID: 21614555; http://dx.doi. org/10.1007/s00210-011-0657-3
    • (2011) Naunyn Schmiedebergs Arch Pharmacol , vol.384 , Issue.2 , pp. 209-216
    • Yang, Y.F.1    Wu, C.C.2    Chen, W.P.3    Chen, Y.L.4    Su, M.J.5
  • 44
    • 0038356717 scopus 로고    scopus 로고
    • Effect of vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal fibroblasts
    • PMID: 12690516
    • Polar MK, Gennings C, Park M, Gupta MS, Gewirtz DA. Effect of vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal fibroblasts. Cancer Chemother Pharmacol 2003; 51(5): 415-21; PMID: 12690516
    • (2003) Cancer Chemother Pharmacol , vol.51 , Issue.5 , pp. 415-421
    • Polar, M.K.1    Gennings, C.2    Park, M.3    Gupta, M.S.4    Gewirtz, D.A.5
  • 46
    • 79955026310 scopus 로고    scopus 로고
    • Death pathways triggered by activated Ras in cancer cells
    • PMID: 21196257
    • Overmeyer JH, Maltese WA. Death pathways triggered by activated Ras in cancer cells. Front Biosci 2011; 16: 1693-713; PMID: 21196257; http://dx.doi.org/10.2741/3814
    • (2011) Front Biosci , vol.16 , pp. 1693-1713
    • Overmeyer, J.H.1    Maltese, W.A.2
  • 47
    • 84890112009 scopus 로고    scopus 로고
    • The mechanism of necroptosis in normal and cancer cells
    • PMID: 24025353
    • Fulda S. The mechanism of necroptosis in normal and cancer cells. Cancer Biol Ther 2013; 14(11): 999-1004; PMID: 24025353; http://dx.doi.org/10.4161/cbt.26428
    • (2013) Cancer Biol Ther , vol.14 , Issue.11 , pp. 999-1004
    • Fulda, S.1
  • 48
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs. P16 bypass, telomerase are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • PMID: 16489012
    • Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AE, Shaw JW et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs. P16 bypass, telomerase are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006; 66(4): 2116-28; PMID: 16489012
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2116-2128
    • Sato, M.1    Vaughan, M.B.2    Girard, L.3    Peyton, M.4    Lee, W.5    Shames, D.S.6    Ramirez, R.D.7    Sunaga, N.8    Gazdar, A.E.9    Shaw, J.W.10
  • 49
    • 0034662644 scopus 로고    scopus 로고
    • P53 promotes selection for Fas-mediated apoptotic resistance
    • PMID: 10969818
    • Maecker HL, Koumenis C, Giaccia AJ. P53 promotes selection for Fas-mediated apoptotic resistance. Cancer Res 2000; 60(16): 4638-44; PMID: 10969818
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4638-4644
    • Maecker, H.L.1    Koumenis, C.2    Giaccia, A.J.3
  • 51
    • 74949127989 scopus 로고    scopus 로고
    • Protocols to detect senescence-associated b-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
    • PMID: 20010931
    • Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence-associated b-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 2009; 4(12): 1798-806; PMID: 20010931; http://dx.doi.org/10.1038/nprot.2009.191
    • (2009) Nat Protoc , vol.4 , Issue.12 , pp. 1798-1806
    • Debacq-Chainiaux, F.1    Erusalimsky, J.D.2    Campisi, J.3    Toussaint, O.4
  • 52
    • 84888882393 scopus 로고    scopus 로고
    • Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest
    • PMID: 24161784
    • Menon VR, Peterson EJ, Valerie K, Farrell NP, Povirk LF. Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochem Pharmacol 2013; 86(12): 1708-20; PMID: 24161784; http://dx.doi.org/10.1016/j.bcp.2013.10.012
    • (2013) Biochem Pharmacol , vol.86 , Issue.12 , pp. 1708-1720
    • Menon, V.R.1    Peterson, E.J.2    Valerie, K.3    Farrell, N.P.4    Povirk, L.F.5
  • 53
    • 77649083117 scopus 로고    scopus 로고
    • Enhanced H2Ax phosphorylation DNA replication fork arrest and cell death in the absence of Chk1
    • PMID: 20053681
    • Gagou EM, Zuazua-Villar P, Meuth M. Enhanced H2Ax phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Bio Cell 2010; 21(5): 739-52; PMID: 20053681; http://dx.doi. org/10.1016/10.1091/mbc.E09-07-0618
    • (2010) Mol Bio Cell , vol.21 , Issue.5 , pp. 739-752
    • Gagou, E.M.1    Zuazua-Villar, P.2    Meuth, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.