Inhibition of MEK/ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells

Biochemical and Biophysical Research Communications

Volumn 456, Issue 1, 2015, Pages 86-91

  Tong, Yongxi ^a   Huang, Haijun ^a   Pan, Hongying ^a  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Autophagy; Chemo sensitization; Hepatocellular carcinoma (HCC); MEK ERK signaling; Pemetrexed

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 METHYLADENINE; AGENTS AFFECTING METABOLISM; BAFLIOMYCIN A1; BECLIN 1; BINIMETINIB; CHLOROQUINE; MITOGEN ACTIVATED PROTEIN KINASE; PEMETREXED; PROTEIN P62; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; GLUTAMIC ACID DERIVATIVE; GREEN FLUORESCENT PROTEIN; GUANINE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CHEMOSENSITIZATION; CLONOGENIC ASSAY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIGHT CHAIN; LIVER CELL CARCINOMA; MTT ASSAY; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER TUMOR; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMATES; GREEN FLUORESCENT PROTEINS; GUANINE; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE KINASES; MEMBRANE PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84919634812     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.11.038     Document Type: Article

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