Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells

International Journal of Oncology

Volumn 48, Issue 2, 2016, Pages 765-773

  Zhao, Qiuyue ^a,b,c,d   Mao, Aihong ^a,b,c,d   Yan, Jiawei ^a,b,c,d   Sun, Chao ^a,b,c   Di, Cuixia ^a,b,c   Zhou, Xin ^a,b,c   Li, Hongyan ^a,b,c   Guo, Ruoshui ^e   Zhang, Hong ^a,b,c  

^a INSTITUTE OF MODERN PHYSICS   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Ionizing radiation; Lung cancer; Notch1; Nuclear factor erythroid 2 related factor 2; ROS

Indexed keywords

CASPASE 3; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE (P) H QUININE OXIDOREDUCTASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NOTCH1 RECEPTOR; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; GCLC PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; NOTCH RECEPTOR; NQO1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

A549 CELL LINE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVE SITE; GENE SILENCING; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; RADIATION INDUCED APOPTOSIS; RADIOSENSITIVITY; RNA INTERFERENCE; RNA ISOLATION; SIGNAL TRANSDUCTION; UPREGULATION; CELL PROTECTION; GENETICS; LUNG TUMOR; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; TUMOR CELL LINE;

ANTIOXIDANTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CYTOPROTECTION; DOWN-REGULATION; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HUMANS; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, NOTCH; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84956934807     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.3301     Document Type: Article

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