Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells

Apoptosis

Volumn 20, Issue 9, 2015, Pages 1242-1252

  Kim, Wanyeon ^a   Youn, Hyesook ^a   Kang, Chulhee ^b   Youn, Buhyun ^a  

^a Pusan National University   (South Korea)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Inflammation; Non small cell lung cancer; Protein phosphatase 1; Radioresistance; Reactive oxygen species

Indexed keywords

ASCORBIC ACID; CASPASE 3; CASPASE 7; LIPOPOLYSACCHARIDE; PHOSPHOPROTEIN PHOSPHATASE 1; REACTIVE OXYGEN METABOLITE; CASPASE; ENZYME ACTIVATOR;

A549 CELL LINE; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL DEATH; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; IRRADIATION; LUNG CANCER CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; RADIOSENSITIVITY; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, NON-SMALL-CELL LUNG; DRUG EFFECTS; GAMMA RADIATION; LUNG NEOPLASMS; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; THERAPEUTIC USE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; ENZYME ACTIVATORS; GAMMA RAYS; HETEROGRAFTS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG NEOPLASMS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED BALB C; MICE, NUDE; PROTEIN PHOSPHATASE 1; RADIATION TOLERANCE; REACTIVE OXYGEN SPECIES;

EID: 84938953481     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1141-1     Document Type: Article

References (43)

1. Koh PK, Faivre-Finn C, Blackhall FH, De Ruysscher D (2012) Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy. Cancer Treat Rev 38:626-640
2. Bussink J, van der Kogel AJ, Kaanders JH (2008) Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 9:288-296
3. Wang L, Yang H, Palmbos PL, Ney G, Detzler TA, Coleman D et al (2014) ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res 74:1778-1788
4. Marampon F, Gravina GL, Zani BM, Popov VM, Fratticci A, Cerasani M et al (2014) Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1alpha functional interplay. Int J Oncol 44:2121-2131
5. Multhoff G, Radons J (2012) Radiation, inflammation, and immune responses in cancer. Front Oncol 2:58
6. Roughton K, Andreasson U, Blomgren K, Kalm M (2013) Lipopolysaccharide-induced inflammation aggravates irradiation-induced injury to the young mouse brain. Dev Neurosci 35:406-415
7. Kim W, Youn H, Kwon T, Kang J, Kim E, Son B et al (2013) PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells. Pharmacol Res 70:90-101
8. Li F, Sethi G (2010) Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805:167-180
9. Sandur SK, Deorukhkar A, Pandey MK, Pabon AM, Shentu S, Guha S et al (2009) Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys 75:534-542
10. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
11. Sethi G, Shanmugam MK, Ramachandran L, Kumar AP, Tergaonkar V (2012) Multifaceted link between cancer and inflammation. Biosci Rep 32:1-15
12. Gonda TA, Tu S, Wang TC (2009) Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle 8:2005-2013
13. Xia L, Mo P, Huang W, Zhang L, Wang Y, Zhu H et al (2012) The TNF-alpha/ROS/HIF-1-induced upregulation of FoxMI expression promotes HCC proliferation and resistance to apoptosis. Carcinogenesis 33:2250-2259
14. Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013) Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways. Cell Cycle 12:826-836
15. O'Loghlen A, Perez-Morgado MI, Salinas M, Martin ME (2003) Reversible inhibition of the protein phosphatase 1 by hydrogen peroxide. Potential regulation of eIF2 alpha phosphorylation in differentiated PC12 cells. Arch Biochem Biophys 417:194-202
16. Garcia A, Cayla X, Guergnon J, Dessauge F, Hospital V, Rebollo MP et al (2003) Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis. Biochimie 85:721-726
17. Li L, Ren CH, Tahir SA, Ren C, Thompson TC (2003) Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol 23:9389-9404
18. Das AK, Sato M, Story MD, Peyton M, Graves R, Redpath S et al (2006) Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res 66:9601-9608
19. Kim W, Youn H, Seong KM, Yang HJ, Yun YJ, Kwon T et al (2011) PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases. Radiat Res 176:539-552
20. Azzam EI, Jay-Gerin JP, Pain D (2012) Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett 327:48-60
21. Olas B, Wachowicz B, Saluk-Juszczak J, Zielinski T, Kaca W, Buczynski A (2001) Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets. Cell Biol Toxicol 17:117-125
22. Li P, Zhao QL, Wu LH, Jawaid P, Jiao YF, Kadowaki M et al (2014) Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner. Apoptosis 19:1043-1053
23. Kim HS, Song MC, Kwak IH, Park TJ, Lim IK (2003) Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem 278:37497-37510
24. Ayllon V, Martinez AC, Garcia A, Cayla X, Rebollo A (2000) Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. EMBO J 19:2237-2246
25. Peng A, Maller JL (2010) Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene 29:5977-5988
26. Blume-Jensen P, Janknecht R, Hunter T (1998) The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 8:779-782
27. Berry DL, Theriault RL, Holmes FA, Parisi VM, Booser DJ, Singletary SE et al (1999) Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol 17:855-861
28. Wu K, House L, Liu W, Cho WC (2012) Personalized targeted therapy for lung cancer. Int J Mol Sci 13:11471-11496
29. Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273
30. Higashiyama M, Okami J, Maeda J, Tokunaga T, Fujiwara A, Kodama K et al (2012) Differences in chemosensitivity between primary and paired metastatic lung cancer tissues: in vitro analysis based on the collagen gel droplet embedded culture drug test (CD-DST). J Thorac Dis 4:40-47
31. Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J et al (2008) Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Ther 7:1772-1781
32. Chae S, Kang KA, Chang WY, Kim MJ, Lee SJ, Lee YS et al (2009) Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo. J Agric Food Chem 57:5777-5782
33. Bandugula VR, N RP (2013) 2-Deoxy-d-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells. Tumour Biol 34:251-259
34. Luo H, Yount C, Lang H, Yang A, Riemer EC, Lyons K et al (2013) Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence. Lung Cancer 81:167-173
35. Yu L, Shang ZF, Hsu FM, Zhang Z, Tumati V, Lin YF et al (2015) NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. Oncotarget 6:3848-3860
36. Mirzayans R, Andrais B, Scott A, Wang YW, Murray D (2013) Ionizing radiation-induced responses in human cells with differing TP53 status. Int J Mol Sci 14:22409-22435
37. Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S et al (2007) Radiation-induced cell signaling: inside-out and outside-in. Mol Cancer Ther 6:789-801
38. Brautigan DL (2013) Protein Ser/Thr phosphatases - the ugly ducklings of cell signalling. FEBS J 280:324-345
39. Klumpp S, Selke D, Krieglstein J (2003) Protein phosphatase type 2C dephosphorylates BAD. Neurochem Int 42:555-560
40. Yang HJ, Youn H, Seong KM, Jin YW, Kim J, Youn B (2013) Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells. J Biol Chem 288:2965-2975
41. Yang HJ, Youn H, Seong KM, Yun YJ, Kim W, Kim YH et al (2011) Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation. Biochem Pharmacol 82:524-534
42. Kim W, Yang HJ, Youn H, Yun YJ, Seong KM, Youn B (2010) Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes. J Radiat Res 51:285-296
43. Kim E, Youn H, Kwon T, Son B, Kang J, Yang HJ et al (2014) PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells. Cancer Res 74:5520-5531