Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus

Human Molecular Genetics

Volumn 24, Issue 24, 2015, Pages 6932-6943

  Li, Yanjie ^a   Lu, Yue ^b   Polak, Urszula ^b,c   Lin, Kevin ^b   Shen, Jianjun ^b   Farmer, Jennifer ^d   Seyer, Lauren ^d   Bhalla, Angela D ^a   Rozwadowska, Natalia ^a,f   Lynch, David R ^d   Butler, Jill Sergesketter ^a   Napierala, Marek ^a,e  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^f INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; MESSENGER RNA PRECURSOR; ADENINE; GUANINE; HISTONE; IRON BINDING PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 9; CLINICAL ARTICLE; CONTROLLED STUDY; DNA STRUCTURE; EPIGENETIC REPRESSION; FEMALE; FIBROBLAST; FRIEDREICH ATAXIA; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GENETIC TRANSCRIPTION; GUANINE ADENINE ADENINE REPEAT; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; MALE; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; RNA SEQUENCE; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION; GENETICS; METABOLISM; SEQUENCE ANALYSIS; TRINUCLEOTIDE REPEAT;

ADENINE; FRIEDREICH ATAXIA; GENE SILENCING; GENETIC LOCI; GUANINE; HISTONES; IRON-BINDING PROTEINS; SEQUENCE ANALYSIS, RNA; TRANSCRIPTION ELONGATION, GENETIC; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84956900422     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv397     Document Type: Article

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