Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

Science

Volumn 305, Issue 5681, 2004, Pages 242-245

  Bulteau, Anne Laure ^a   O'Neill, Heather A ^b   Kennedy, Mary Claire ^c   Ikeda Saito, Masao ^d   Isaya, Grazia ^b   Szweda, Luke I ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mayo Clinic   (United States)

^c GANNON UNIVERSITY   (United States)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; OXIDATION; PROTEINS;

MITOCHONDRIA; OXIDANTS;

CYTOLOGY;

ACONITATE HYDRATASE; CHAPERONE; CITRIC ACID; FRATAXIN; IRON CHAPERONE PROTEIN; IRON SULFUR PROTEIN; UNCLASSIFIED DRUG;

BIOLOGY;

ARTICLE; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REACTIVATION; ENZYME REGULATION; HUMAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ACONITATE HYDRATASE; ANIMALS; CITRIC ACID; DITHIOTHREITOL; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; FERROUS COMPOUNDS; HYDROGEN PEROXIDE; IRON; IRON-BINDING PROTEINS; MALE; MITOCHONDRIA; MITOCHONDRIA, HEART; MOLECULAR CHAPERONES; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 3042763187     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098991     Document Type: Article

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33. We thank R. Lill. (Institute Zytobiologie, Philipps-Universitat, Marburg, Germany) for antisera to yeast aconitase and A. M. Tartakoff (Department of Pathology, Case Western Reserve University) for help and discussion. Supported by American Heart Association grant no. 0325305B (A.-L.B.); National Institute of Neurological Disorders and Stroke grant no. NRSA 44748 (H.A.O.); National Institute on Aging grant nos. AG-16339 (L.I.S.) and AG-15709 (G.I.); and grants-in-aid nos. 1214720 and 16370056 (M.I.-S.) from the Japanese Ministry of Education, Science, Culture, Sport, and Technology.