메뉴 건너뛰기




Volumn 55, Issue 3, 2016, Pages 255-267

Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis

Author keywords

Autophagy; Colitis associated colon carcinogenesis; Inflammation; Melatonin; Nrf2; Oxidative stress

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ANTINEOPLASTIC AGENT; CARCINOGEN; DEXTRAN SULFATE; MELATONIN; NFE2L2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR NRF2;

EID: 84956797932     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22274     Document Type: Article
Times cited : (88)

References (60)
  • 1
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh M, Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol 2011; 11:9-20.
    • (2011) Nat Rev Immunol , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 2
    • 84861335956 scopus 로고    scopus 로고
    • Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies
    • Jess T, Rungoe C, Peyrin-Biroulet L. Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol 2012; 10:639-645.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 639-645
    • Jess, T.1    Rungoe, C.2    Peyrin-Biroulet, L.3
  • 3
    • 0034327361 scopus 로고    scopus 로고
    • Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy
    • Izuishi K, Kato K, Ogura T, Kinoshita T, Esumi H. Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy. Cancer Res 2000; 60:6201-6207.
    • (2000) Cancer Res , vol.60 , pp. 6201-6207
    • Izuishi, K.1    Kato, K.2    Ogura, T.3    Kinoshita, T.4    Esumi, H.5
  • 4
    • 35448980704 scopus 로고    scopus 로고
    • Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation
    • Sato K, Tsuchihara K, Fujii S, et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 2007; 67:9677-9684.
    • (2007) Cancer Res , vol.67 , pp. 9677-9684
    • Sato, K.1    Tsuchihara, K.2    Fujii, S.3
  • 5
    • 0002549377 scopus 로고
    • The lysosome
    • De Duve C. The lysosome. Sci Am 1963; 208:64-72.
    • (1963) Sci Am , vol.208 , pp. 64-72
    • De Duve, C.1
  • 6
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N. Autophagy: Process and function. Genes Dev 2007; 21:2861-2873.
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 8
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 2000; 19:5720-5728.
    • (2000) Embo J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 9
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G, Lamark T, Brech A, et al. P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-614.
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3
  • 10
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv S, Clausen TH, Lamark T, et al. P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-24145.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3
  • 11
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 12
    • 67650727404 scopus 로고    scopus 로고
    • Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells
    • Zhang H, Kong X, Kang J, et al. Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci 2009; 110:376-388.
    • (2009) Toxicol Sci , vol.110 , pp. 376-388
    • Zhang, H.1    Kong, X.2    Kang, J.3
  • 13
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010; 12:213-223.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3
  • 14
    • 84858748850 scopus 로고    scopus 로고
    • Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and alpha-synuclein aggregation
    • Chang CF, Huang HJ, Lee HC, Hung KC, Wu RT, Lin AM. Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and alpha-synuclein aggregation. J Pineal Res 2012; 52:312-321.
    • (2012) J Pineal Res , vol.52 , pp. 312-321
    • Chang, C.F.1    Huang, H.J.2    Lee, H.C.3    Hung, K.C.4    Wu, R.T.5    Lin, A.M.6
  • 15
    • 33645923392 scopus 로고    scopus 로고
    • Could melatonin unbalance the equilibrium between autophagy and invasive processes
    • Coto-Montes A, Tomas-Zapico C. Could melatonin unbalance the equilibrium between autophagy and invasive processes. Autophagy 2006; 2:126-128.
    • (2006) Autophagy , vol.2 , pp. 126-128
    • Coto-Montes, A.1    Tomas-Zapico, C.2
  • 16
    • 33644903543 scopus 로고    scopus 로고
    • Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis
    • Esrefoglu M, Gul M, Ates B, Selimoglu MA. Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. J Pineal Res 2006; 40:92-97.
    • (2006) J Pineal Res , vol.40 , pp. 92-97
    • Esrefoglu, M.1    Gul, M.2    Ates, B.3    Selimoglu, M.A.4
  • 17
    • 84896136968 scopus 로고    scopus 로고
    • Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus
    • San-Miguel B, Crespo I, Vallejo D, et al. Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus. J Pineal Res 2014; 56:313-321.
    • (2014) J Pineal Res , vol.56 , pp. 313-321
    • San-Miguel, B.1    Crespo, I.2    Vallejo, D.3
  • 18
    • 84897421097 scopus 로고    scopus 로고
    • Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats
    • Zheng Y, Hou J, Liu J, et al. Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats. J Pharmacol Sci 2014; 124:354-364.
    • (2014) J Pharmacol Sci , vol.124 , pp. 354-364
    • Zheng, Y.1    Hou, J.2    Liu, J.3
  • 19
    • 77955123767 scopus 로고    scopus 로고
    • Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin
    • Crespo I, Miguel BS, Laliena A, et al. Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin. J Pineal Res 2010; 49:193-200.
    • (2010) J Pineal Res , vol.49 , pp. 193-200
    • Crespo, I.1    Miguel, B.S.2    Laliena, A.3
  • 20
    • 84877246310 scopus 로고    scopus 로고
    • The effect of preoperative melatonin on nuclear erythroid 2-related factor 2 activation in patients undergoing coronary artery bypass grafting surgery
    • Haghjooy Javanmard S, Ziaei A, Ziaei S, Ziaei E, Mirmohammad-Sadeghi M. The effect of preoperative melatonin on nuclear erythroid 2-related factor 2 activation in patients undergoing coronary artery bypass grafting surgery. Oxid Med Cell Longev 2013; 2013:676829.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 676829
    • Haghjooy Javanmard, S.1    Ziaei, A.2    Ziaei, S.3    Ziaei, E.4    Mirmohammad-Sadeghi, M.5
  • 21
    • 84898740707 scopus 로고    scopus 로고
    • A review of the use of melatonin in ulcerative colitis: Experimental evidence and new approaches
    • Jena G, Trivedi PP. A review of the use of melatonin in ulcerative colitis: Experimental evidence and new approaches. Inflamm Bowel Dis 2013; 20:553-563.
    • (2013) Inflamm Bowel Dis , vol.20 , pp. 553-563
    • Jena, G.1    Trivedi, P.P.2
  • 22
    • 77749310344 scopus 로고    scopus 로고
    • Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats
    • Jung KH, Hong SW, Zheng HM, et al. Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. J Pineal Res 2010; 48:239-250.
    • (2010) J Pineal Res , vol.48 , pp. 239-250
    • Jung, K.H.1    Hong, S.W.2    Zheng, H.M.3
  • 23
    • 77950648335 scopus 로고    scopus 로고
    • Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat
    • Tripathi DN, Jena GB. Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat. J Pineal Res 2010; 48:324-331.
    • (2010) J Pineal Res , vol.48 , pp. 324-331
    • Tripathi, D.N.1    Jena, G.B.2
  • 24
    • 84890130576 scopus 로고    scopus 로고
    • Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms
    • Trivedi PP, Jena GB. Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci 2013; 58:3460-3474.
    • (2013) Dig Dis Sci , vol.58 , pp. 3460-3474
    • Trivedi, P.P.1    Jena, G.B.2
  • 25
    • 84862217131 scopus 로고    scopus 로고
    • Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model
    • Wang Z, Ma C, Meng CJ, et al. Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res 2012; 53:129-137.
    • (2012) J Pineal Res , vol.53 , pp. 129-137
    • Wang, Z.1    Ma, C.2    Meng, C.J.3
  • 26
    • 0034111475 scopus 로고    scopus 로고
    • Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats
    • Anisimov VN, Popovich IG, Shtylik AV, et al. Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1, 2-dimethylhydrazine in rats. Exp Toxicol Pathol 2000; 52:71-76.
    • (2000) Exp Toxicol Pathol , vol.52 , pp. 71-76
    • Anisimov, V.N.1    Popovich, I.G.2    Shtylik, A.V.3
  • 27
    • 34447500401 scopus 로고    scopus 로고
    • Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture
    • Garcia-Navarro A, Gonzalez-Puga C, Escames G, et al. Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. J Pineal Res 2007; 43:195-205.
    • (2007) J Pineal Res , vol.43 , pp. 195-205
    • Garcia-Navarro, A.1    Gonzalez-Puga, C.2    Escames, G.3
  • 28
    • 84898941204 scopus 로고    scopus 로고
    • Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-kappabeta
    • Leon J, Casado J, Jimenez Ruiz SM, et al. Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-kappabeta. J Pineal Res 2014; 56:415-426.
    • (2014) J Pineal Res , vol.56 , pp. 415-426
    • Leon, J.1    Casado, J.2    Jimenez Ruiz, S.M.3
  • 30
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings
    • Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 1987; 37:147-151.
    • (1987) Cancer Lett , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 31
    • 34047261442 scopus 로고    scopus 로고
    • Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: A sequential analysis
    • Zoghbi S, Drouin E, Claustre J, Bara J, Scoazec JY, Plaisancie P. Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1, 2-dimethylhydrazine in rat: A sequential analysis. Int J Oncol 2007; 30:489-497.
    • (2007) Int J Oncol , vol.30 , pp. 489-497
    • Zoghbi, S.1    Drouin, E.2    Claustre, J.3    Bara, J.4    Scoazec, J.Y.5    Plaisancie, P.6
  • 32
    • 84859165038 scopus 로고    scopus 로고
    • Dextran sulfate sodium-induced ulcerative colitis leads to increased hematopoiesis and induces both local as well as systemic genotoxicity in mice
    • Trivedi PP, Jena GB. Dextran sulfate sodium-induced ulcerative colitis leads to increased hematopoiesis and induces both local as well as systemic genotoxicity in mice. Mutat Res 2012; 744:172-183.
    • (2012) Mutat Res , vol.744 , pp. 172-183
    • Trivedi, P.P.1    Jena, G.B.2
  • 33
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 34
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979; 582:67-78.
    • (1979) Biochim Biophys Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 35
    • 0017154144 scopus 로고
    • Production of intestinal and other tumors by 1, 2-dimethylhydrazine dihydrochloride in mice. I. A light and transmission electron microscopic study of colonic neoplasms
    • Toth B, Malick L, Shimizu H. Production of intestinal and other tumors by 1, 2-dimethylhydrazine dihydrochloride in mice. I. A light and transmission electron microscopic study of colonic neoplasms. Am J Pathol 1976; 84:69-86.
    • (1976) Am J Pathol , vol.84 , pp. 69-86
    • Toth, B.1    Malick, L.2    Shimizu, H.3
  • 36
    • 84880339863 scopus 로고    scopus 로고
    • Role of alpha-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis
    • Trivedi PP, Jena GB. Role of alpha-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: studies on inflammation, oxidative stress, DNA damage and fibrosis. Food Chem Toxicol 2013; 59:339-355.
    • (2013) Food Chem Toxicol , vol.59 , pp. 339-355
    • Trivedi, P.P.1    Jena, G.B.2
  • 37
    • 0036798932 scopus 로고    scopus 로고
    • Gastrointestinal melatonin: Localization, function, and clinical relevance
    • Bubenik GA. Gastrointestinal melatonin: Localization, function, and clinical relevance. Dig Dis Sci 2002; 47:2336-2348.
    • (2002) Dig Dis Sci , vol.47 , pp. 2336-2348
    • Bubenik, G.A.1
  • 38
    • 33646160623 scopus 로고    scopus 로고
    • Inflammation, a key event in cancer development
    • Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res 2006; 4:221-233.
    • (2006) Mol Cancer Res , vol.4 , pp. 221-233
    • Lu, H.1    Ouyang, W.2    Huang, C.3
  • 39
    • 84860014863 scopus 로고    scopus 로고
    • Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA
    • Timofeeva OA, Chasovskikh S, Lonskaya I, et al. Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. J Biol Chem 2012; 287:14192-14200.
    • (2012) J Biol Chem , vol.287 , pp. 14192-14200
    • Timofeeva, O.A.1    Chasovskikh, S.2    Lonskaya, I.3
  • 40
    • 13444309088 scopus 로고    scopus 로고
    • Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
    • Yang J, Chatterjee-Kishore M, Staugaitis SM, et al. Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 2005; 65:939-947.
    • (2005) Cancer Res , vol.65 , pp. 939-947
    • Yang, J.1    Chatterjee-Kishore, M.2    Staugaitis, S.M.3
  • 41
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007; 21:1396-1408.
    • (2007) Genes Dev , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 42
    • 79952573098 scopus 로고    scopus 로고
    • Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro
    • Bonnefont-Rousselot D, Collin F, Jore D, Gardes-Albert M. Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro. J Pineal Res 2011; 50:328-335.
    • (2011) J Pineal Res , vol.50 , pp. 328-335
    • Bonnefont-Rousselot, D.1    Collin, F.2    Jore, D.3    Gardes-Albert, M.4
  • 43
    • 0030272628 scopus 로고    scopus 로고
    • Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen
    • Chuang JI, Mohan N, Meltz ML, Reiter RJ. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int 1996; 20:687-692.
    • (1996) Cell Biol Int , vol.20 , pp. 687-692
    • Chuang, J.I.1    Mohan, N.2    Meltz, M.L.3    Reiter, R.J.4
  • 44
    • 36849020501 scopus 로고    scopus 로고
    • Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress
    • De Filippis D, Iuvone T, Esposito G, et al. Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress. J Pineal Res 2008; 44:45-51.
    • (2008) J Pineal Res , vol.44 , pp. 45-51
    • De Filippis, D.1    Iuvone, T.2    Esposito, G.3
  • 45
    • 0038389797 scopus 로고    scopus 로고
    • Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis
    • Dong WG, Mei Q, Yu JP, Xu JM, Xiang L, Xu Y. Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol 2003; 9:1307-1311.
    • (2003) World J Gastroenterol , vol.9 , pp. 1307-1311
    • Dong, W.G.1    Mei, Q.2    Yu, J.P.3    Xu, J.M.4    Xiang, L.5    Xu, Y.6
  • 46
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: A physicochemical examination. J Pineal Res 2011; 51:1-16.
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 47
    • 0034763416 scopus 로고    scopus 로고
    • Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates
    • Gitto E, Tan DX, Reiter RJ, et al. Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. J Pharm Pharmacol 2001; 53:1393-1401.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1393-1401
    • Gitto, E.1    Tan, D.X.2    Reiter, R.J.3
  • 49
    • 0036482282 scopus 로고    scopus 로고
    • Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger
    • Tan DX, Reiter RJ, Manchester LC, et al. Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002; 2:181-197.
    • (2002) Curr Top Med Chem , vol.2 , pp. 181-197
    • Tan, D.X.1    Reiter, R.J.2    Manchester, L.C.3
  • 50
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment
    • Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11:777-790.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 777-790
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 51
    • 84883030202 scopus 로고    scopus 로고
    • Autophagy: Key pathway of TNF-induced inflammatory bone loss
    • Lin NY, Stefanica A, Distler JH. Autophagy: Key pathway of TNF-induced inflammatory bone loss. Autophagy 2013; 9:1253-1255.
    • (2013) Autophagy , vol.9 , pp. 1253-1255
    • Lin, N.Y.1    Stefanica, A.2    Distler, J.H.3
  • 52
    • 34447622276 scopus 로고    scopus 로고
    • Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels
    • Moore MN, Viarengo A, Donkin P, Hawkins AJ. Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels. Aquat Toxicol 2007; 84:80-91.
    • (2007) Aquat Toxicol , vol.84 , pp. 80-91
    • Moore, M.N.1    Viarengo, A.2    Donkin, P.3    Hawkins, A.J.4
  • 53
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. Embo J 2007; 26:1749-1760.
    • (2007) Embo J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 54
    • 63449135735 scopus 로고    scopus 로고
    • Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat
    • Wu HH, Hsiao TY, Chien CT, Lai MK. Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat. J Biomed Sci 2009; 16:19.
    • (2009) J Biomed Sci , vol.16 , pp. 19
    • Wu, H.H.1    Hsiao, T.Y.2    Chien, C.T.3    Lai, M.K.4
  • 55
    • 84879604162 scopus 로고    scopus 로고
    • NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury
    • Zeng M, Wei X, Wu Z, et al. NF-kappaB-mediated induction of autophagy in cardiac ischemia/reperfusion injury. Biochem Biophys Res Commun 2013; 436:180-185.
    • (2013) Biochem Biophys Res Commun , vol.436 , pp. 180-185
    • Zeng, M.1    Wei, X.2    Wu, Z.3
  • 56
    • 84924314524 scopus 로고    scopus 로고
    • Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation
    • de Luxan-Delgado B, Caballero B, Potes Y, et al. Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation. J Pineal Res 2013; in press.
    • (2013) J Pineal Res
    • de Luxan-Delgado, B.1    Caballero, B.2    Potes, Y.3
  • 57
    • 77749336538 scopus 로고    scopus 로고
    • Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells
    • Yoo YM, Jeung EB. Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells. J Pineal Res 2010; 48:204-211.
    • (2010) J Pineal Res , vol.48 , pp. 204-211
    • Yoo, Y.M.1    Jeung, E.B.2
  • 58
    • 83555174800 scopus 로고    scopus 로고
    • Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells
    • Zhou H, Chen J, Lu X, et al. Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells. J Pineal Res 2012; 52:120-127.
    • (2012) J Pineal Res , vol.52 , pp. 120-127
    • Zhou, H.1    Chen, J.2    Lu, X.3
  • 59
    • 78349253806 scopus 로고    scopus 로고
    • The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy
    • Nopparat C, Porter JE, Ebadi M, Govitrapong P. The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. J Pineal Res 2010; 49:382-389.
    • (2010) J Pineal Res , vol.49 , pp. 382-389
    • Nopparat, C.1    Porter, J.E.2    Ebadi, M.3    Govitrapong, P.4
  • 60
    • 84891709303 scopus 로고    scopus 로고
    • Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion
    • Kang JW, Cho HI, Lee SM. Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion. Cell Physiol Biochem 2014; 33:23-36.
    • (2014) Cell Physiol Biochem , vol.33 , pp. 23-36
    • Kang, J.W.1    Cho, H.I.2    Lee, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.