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Volumn 22, Issue 1, 2016, Pages 3-17

The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models

Author keywords

Animal models; antioxidants; Crohn's disease; lipid peroxidation; reactive oxygen species; ulcerative colitis

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; EPIDERMAL GROWTH FACTOR; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; KYNURENINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA1; TRYPTOPHAN; REACTIVE NITROGEN SPECIES;

EID: 84955458118     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.173753     Document Type: Review
Times cited : (234)

References (149)
  • 1
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. Inflammatory bowel disease: Cause and immunobiology. Lancet 2007;369:1627-40.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 2
    • 84856971587 scopus 로고    scopus 로고
    • Reversal of idiopathic thrombocytopenic purpura [ITP] with fecal microbiota transplantation [FMT]
    • Borody TJ, Campbell J, Torres M, Nowak A, Leis S. Reversal of idiopathic thrombocytopenic purpura [ITP] with fecal microbiota transplantation [FMT]. Am J Gastroenterol 2011;106:S352.
    • (2011) Am J Gastroenterol , vol.106 , pp. S352
    • Borody, T.J.1    Campbell, J.2    Torres, M.3    Nowak, A.4    Leis, S.5
  • 4
    • 0030906870 scopus 로고    scopus 로고
    • Antioxidants and human disease: A general introduction
    • Halliwell B. Antioxidants and human disease: A general introduction. Nut Rev 1997;55:S44-52.
    • (1997) Nut Rev , vol.55 , pp. 544-552
    • Halliwell, B.1
  • 5
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: An overview
    • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 1990;186:1-85.
    • (1990) Methods Enzymol , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.2
  • 6
    • 0027189788 scopus 로고
    • Free radical-lipid interactions and their pathological consequences
    • Rice-Evans C, Burdon R. Free radical-lipid interactions and their pathological consequences. Prog Lipid Res 1993;32:71-110.
    • (1993) Prog Lipid Res , vol.32 , pp. 71-110
    • Rice-Evans, C.1    Burdon, R.2
  • 7
    • 0024239038 scopus 로고    scopus 로고
    • Antioxidant defenses and lipid peroxidation in human blood plasma
    • Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 1998;85:9748-752.
    • (1998) Proc Natl Acad Sci USA , vol.85 , pp. 9748-9752
    • Frei, B.1    Stocker, R.2    Ames, B.N.3
  • 8
    • 0031776230 scopus 로고    scopus 로고
    • Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite
    • Thomas SR, Davies MJ, Stocker R. Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite. Chem Res Toxicol 1998;11:484-94.
    • (1998) Chem Res Toxicol , vol.11 , pp. 484-494
    • Thomas, S.R.1    Davies, M.J.2    Stocker, R.3
  • 9
    • 0034001883 scopus 로고    scopus 로고
    • Both iron deficiency and daily iron supplements increase lipid peroxidation in rats
    • Knutson MD, Walter PB, Ames BN, Viteri FE. Both iron deficiency and daily iron supplements increase lipid peroxidation in rats. J Nutr 2000;130:621-8.
    • (2000) J Nutr , vol.130 , pp. 621-628
    • Knutson, M.D.1    Walter, P.B.2    Ames, B.N.3    Viteri, F.E.4
  • 11
    • 0035659325 scopus 로고    scopus 로고
    • Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis
    • Carrier J, Aghdassi E, Platt I, Cullen J, Allard JP. Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther 2001;15:1989-99.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1989-1999
    • Carrier, J.1    Aghdassi, E.2    Platt, I.3    Cullen, J.4    Allard, J.P.5
  • 12
    • 0036790056 scopus 로고    scopus 로고
    • Iron supplementation increases disease activity and Vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis
    • Carrier J, Aghdassi E, Cullen J, Allard JP. Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr 2002;132:3146-50.
    • (2002) J Nutr , vol.132 , pp. 3146-3150
    • Carrier, J.1    Aghdassi, E.2    Cullen, J.3    Allard, J.P.4
  • 15
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63.
    • (1985) N Engl J Med , vol.312 , pp. 159-163
    • McCord, J.M.1
  • 16
    • 0032755055 scopus 로고    scopus 로고
    • The role of xanthine oxidase and the effects of antioxidants in ischemia reperfusion cell injury
    • Canãs PE. The role of xanthine oxidase and the effects of antioxidants in ischemia reperfusion cell injury. Acta Physiol Pharmacol Ther Latinoam 1999;49:13-20.
    • (1999) Acta Physiol Pharmacol Ther Latinoam , vol.49 , pp. 13-20
    • Canãs, P.E.1
  • 17
    • 0026764691 scopus 로고
    • Mechanism of action of biological antioxidants
    • Krinsky NI. Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 1992;200:248-54.
    • (1992) Proc Soc Exp Biol Med , vol.200 , pp. 248-254
    • Krinsky, N.I.1
  • 18
    • 0023464342 scopus 로고
    • Free radical tissue damage: Protective role of antioxidant nutrients
    • Machlin LJ, Bendich A. Free radical tissue damage: Protective role of antioxidant nutrients. FASEB J 1987;1:441-5.
    • (1987) FASEB J , vol.1 , pp. 441-445
    • Machlin, L.J.1    Bendich, A.2
  • 19
    • 0036804710 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and nutrition
    • Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition 2002;18:872-9.
    • (2002) Nutrition , vol.18 , pp. 872-879
    • Fang, Y.Z.1    Yang, S.2    Wu, G.3
  • 20
    • 0025314685 scopus 로고
    • Role of oxygen free radicals in carcinogenesis and brain ischemia
    • Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 1990;4:2587-97.
    • (1990) FASEB J , vol.4 , pp. 2587-2597
    • Floyd, R.A.1
  • 21
    • 84886914348 scopus 로고    scopus 로고
    • Concepts of oxidative stress and antioxidant defense in Crohn's disease
    • Alzoghaibi MA. Concepts of oxidative stress and antioxidant defense in Crohn's disease. World J Gastroenterol 2013;19:6540-7.
    • (2013) World J Gastroenterol , vol.19 , pp. 6540-6547
    • Alzoghaibi, M.A.1
  • 25
    • 0035871692 scopus 로고    scopus 로고
    • Oxidative damages are critical in pathogenesis of reflux esophagitis: Implication of antioxidants in its treatment
    • Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim YB, et al. Oxidative damages are critical in pathogenesis of reflux esophagitis: Implication of antioxidants in its treatment. Free Radic Biol Med 2005;30:905-15.
    • (2005) Free Radic Biol Med , vol.30 , pp. 905-915
    • Oh, T.Y.1    Lee, J.S.2    Ahn, B.O.3    Cho, H.4    Kim, W.B.5    Kim, Y.B.6
  • 27
    • 0026570302 scopus 로고
    • Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa
    • Mai UE, Perez-Perez GI, Allen JB, Wahl SM, Blaser MJ, Smith PD. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J Exp Med 1992;175:517-25.
    • (1992) J Exp Med , vol.175 , pp. 517-525
    • Mai, U.E.1    Perez-Perez, G.I.2    Allen, J.B.3    Wahl, S.M.4    Blaser, M.J.5    Smith, P.D.6
  • 28
    • 0027176157 scopus 로고
    • An international association between Helicobacter pylori infection and gastric cancer
    • The EUROGAST Study Group
    • An international association between Helicobacter pylori infection and gastric cancer. The EUROGAST Study Group. Lancet 1993;341:1359-62.
    • (1993) Lancet , vol.341 , pp. 1359-1362
  • 29
    • 0028326328 scopus 로고
    • Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo
    • Davies GR, Simmonds NJ, Stevens TR, Sheaff MT, Banatvala N, Laurenson IF, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994;35:179-85.
    • (1994) Gut , vol.35 , pp. 179-185
    • Davies, G.R.1    Simmonds, N.J.2    Stevens, T.R.3    Sheaff, M.T.4    Banatvala, N.5    Laurenson, I.F.6
  • 30
    • 0028955796 scopus 로고
    • Determinants for the development of chronic atrophic gastritis and intestinal metaplasia in the stomach
    • Farinati F, Cardin R, Libera GD, Rugge M, Herszènyi L, Di Mario F, et al. Determinants for the development of chronic atrophic gastritis and intestinal metaplasia in the stomach. Eur J Cancer Prev 1995;4:181-6.
    • (1995) Eur J Cancer Prev , vol.4 , pp. 181-186
    • Farinati, F.1    Cardin, R.2    Libera, G.D.3    Rugge, M.4    Herszènyi, L.5    Di Mario, F.6
  • 31
    • 0037357426 scopus 로고    scopus 로고
    • Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models
    • Seril DN, Liao J, Yang G, Yang CS. Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models. Carcinogenesis 2003;24:353-62.
    • (2003) Carcinogenesis , vol.24 , pp. 353-362
    • Seril, D.N.1    Liao, J.2    Yang, G.3    Yang, C.S.4
  • 32
  • 34
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971;231:232-5.
    • (1971) Nat New Biol , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 35
    • 77955660458 scopus 로고    scopus 로고
    • Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    • Omatsu T, Naito Y, Handa O, Mizushima K, Hayashi N, Qin Y, et al. Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury. J Gastroenterol 2005;45:692-702.
    • (2005) J Gastroenterol , vol.45 , pp. 692-702
    • Omatsu, T.1    Naito, Y.2    Handa, O.3    Mizushima, K.4    Hayashi, N.5    Qin, Y.6
  • 36
    • 33645022077 scopus 로고    scopus 로고
    • Is non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy
    • Adebayo D, Bjarnason I. Is non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J 2006;82:186-91.
    • (2006) Postgrad Med J , vol.82 , pp. 186-191
    • Adebayo, D.1    Bjarnason, I.2
  • 37
    • 33646484112 scopus 로고    scopus 로고
    • Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen
    • Chattopadhyay I, Bandyopadhyay U, Biswas B, Maity P, Banerjee RK. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic Biol Med 2006;40:1397-408.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1397-1408
    • Chattopadhyay, I.1    Bandyopadhyay, U.2    Biswas, B.3    Maity, P.4    Banerjee, R.K.5
  • 38
    • 68749085157 scopus 로고    scopus 로고
    • Rescue strategies against non-steroidal anti-inflammatory drug-induced gastroduodenal damage
    • Lim YJ, Lee JS, Ku YS, Hahm KB. Rescue strategies against non-steroidal anti-inflammatory drug-induced gastroduodenal damage. J Gastroenterol Hepatol 2009;24:1169-78.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1169-1178
    • Lim, Y.J.1    Lee, J.S.2    Ku, Y.S.3    Hahm, K.B.4
  • 40
    • 27744479515 scopus 로고    scopus 로고
    • Oxidative damage in an experimentally induced gastric and gastroduodenal reflux model
    • Erbil Y, Türkoglu U, Barbaros U, Balik E, Olgac V, Kaya H, et al. Oxidative damage in an experimentally induced gastric and gastroduodenal reflux model. Surg Innov 2005;12:219-25.
    • (2005) Surg Innov , vol.12 , pp. 219-225
    • Erbil, Y.1    Türkoglu, U.2    Barbaros, U.3    Balik, E.4    Olgac, V.5    Kaya, H.6
  • 41
    • 34249788142 scopus 로고    scopus 로고
    • Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: Relevance to the pathogenesis of Barrett's oesophagus
    • Dvorak K, Payne CM, Chavarria M, Ramsey L, Dvorakova B, Bernstein H, et al. Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: Relevance to the pathogenesis of Barrett's oesophagus. Gut 2007;56:763-71.
    • (2007) Gut , vol.56 , pp. 763-771
    • Dvorak, K.1    Payne, C.M.2    Chavarria, M.3    Ramsey, L.4    Dvorakova, B.5    Bernstein, H.6
  • 45
    • 0031910636 scopus 로고    scopus 로고
    • Vitamins A and e serum levels in children and young adults with inflammatory bowel disease: Effect of disease activity
    • Bousvaros A, Zurakowski D, Duggan C, Law T, Rifai N, Goldberg NE, et al. Vitamins A and E serum levels in children and young adults with inflammatory bowel disease: Effect of disease activity. J Pediatr Gastroenterol Nutr 1998;26:129-35.
    • (1998) J Pediatr Gastroenterol Nutr , vol.26 , pp. 129-135
    • Bousvaros, A.1    Zurakowski, D.2    Duggan, C.3    Law, T.4    Rifai, N.5    Goldberg, N.E.6
  • 46
    • 0035080001 scopus 로고    scopus 로고
    • Low serum and bone Vitamin K status in patients with longstanding Crohn's disease: Another pathogenetic factor of osteoporosis in Crohn's disease
    • Schoon EJ, Müller MC, Vermeer C, Schurgers LJ, Brummer RJ, Stockbrügger RW. Low serum and bone vitamin K status in patients with longstanding Crohn's disease: Another pathogenetic factor of osteoporosis in Crohn's disease? Gut 2001;48:473-7.
    • (2001) Gut , vol.48 , pp. 473-477
    • Schoon, E.J.1    Müller, M.C.2    Vermeer, C.3    Schurgers, L.J.4    Brummer, R.J.5    Stockbrügger, R.W.6
  • 47
    • 3242666889 scopus 로고    scopus 로고
    • Measurement of Vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyVitamin D and low bone mineral density
    • Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, et al. Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Gut 2004;53:1129-36.
    • (2004) Gut , vol.53 , pp. 1129-1136
    • Abreu, M.T.1    Kantorovich, V.2    Vasiliauskas, E.A.3    Gruntmanis, U.4    Matuk, R.5    Daigle, K.6
  • 50
    • 79251565517 scopus 로고    scopus 로고
    • Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases
    • Ghishan FK, Kiela PR. Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol 2005;300:G191-201.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G191-201
    • Ghishan, F.K.1    Kiela, P.R.2
  • 51
    • 84859181302 scopus 로고    scopus 로고
    • The influence of deficiencies of essential trace elements and vitamins on the course of Crohn's disease
    • Was̈ko-Czopnik D, Paradowski L. The influence of deficiencies of essential trace elements and vitamins on the course of Crohn's disease. Adv Clin Exp Med 2012;21:5-11.
    • (2012) Adv Clin Exp Med , vol.21 , pp. 5-11
    • Was̈ko-Czopnik, D.1    Paradowski, L.2
  • 52
    • 0031951719 scopus 로고    scopus 로고
    • Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis
    • Reimund JM, Allison AC, Muller CD, Dumont S, Kenney JS, Baumann R, et al. Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis. Eur J Clin Invest 1998;28:145-50.
    • (1998) Eur J Clin Invest , vol.28 , pp. 145-150
    • Reimund, J.M.1    Allison, A.C.2    Muller, C.D.3    Dumont, S.4    Kenney, J.S.5    Baumann, R.6
  • 53
    • 0345688219 scopus 로고    scopus 로고
    • Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease
    • Alzoghaibi MA, Walsh SW, Willey A, Fowler AA 3 rd, Graham MF. Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease. Clin Nutr 2003;22:529-35.
    • (2003) Clin Nutr , vol.22 , pp. 529-535
    • Alzoghaibi, M.A.1    Walsh, S.W.2    Willey, A.3    Fowler, A.A.4    Graham, M.F.5
  • 54
    • 0029240465 scopus 로고
    • Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients
    • Buffinton GD, Doe WF. Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients. Free Radic Res 1995;22:131-43.
    • (1995) Free Radic Res , vol.22 , pp. 131-143
    • Buffinton, G.D.1    Doe, W.F.2
  • 55
    • 0031969403 scopus 로고    scopus 로고
    • Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission
    • Geerling BJ, Badart-Smook A, Stockbrügger RW, Brummer RJ. Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. Am J Clin Nutr 1998;67:919-26.
    • (1998) Am J Clin Nutr , vol.67 , pp. 919-926
    • Geerling, B.J.1    Badart-Smook, A.2    Stockbrügger, R.W.3    Brummer, R.J.4
  • 56
    • 0032518001 scopus 로고    scopus 로고
    • Nutritional deficiencies and complications in chronic inflammatory bowel diseases
    • Rath HC, Caesar I, Roth M, Schölmerich J. Nutritional deficiencies and complications in chronic inflammatory bowel diseases. Med Klin (Munich) 1998;93:6-10.
    • (1998) Med Klin (Munich) , vol.93 , pp. 6-10
    • Rath, H.C.1    Caesar, I.2    Roth, M.3    Schölmerich, J.4
  • 57
    • 0032717446 scopus 로고    scopus 로고
    • The relation between antioxidant status and alterations in fatty acid profile in patients with Crohn disease and controls
    • Geerling BJ, Houwelingen AC, Badart-Smook A, Stockbrügger RW, Brummer RJ. The relation between antioxidant status and alterations in fatty acid profile in patients with Crohn disease and controls. Scand J Gastroenterol 1999;34:1108-16.
    • (1999) Scand J Gastroenterol , vol.34 , pp. 1108-1116
    • Geerling, B.J.1    Houwelingen, A.C.2    Badart-Smook, A.3    Stockbrügger, R.W.4    Brummer, R.J.5
  • 59
    • 49949117379 scopus 로고    scopus 로고
    • Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease
    • Hengstermann S, Valentini L, Schaper L, Buning C, Koernicke T, Maritschnegg M, et al. Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease. Clin Nutr 2008;27:571-8.
    • (2008) Clin Nutr , vol.27 , pp. 571-578
    • Hengstermann, S.1    Valentini, L.2    Schaper, L.3    Buning, C.4    Koernicke, T.5    Maritschnegg, M.6
  • 60
    • 44749085151 scopus 로고    scopus 로고
    • Malnutrition and impaired muscle strength in patients with Crohn's disease and ulcerative colitis in remission
    • Valentini L, Schaper L, Buning C, Hengstermann S, Koernicke T, Tillinger W, et al. Malnutrition and impaired muscle strength in patients with Crohn's disease and ulcerative colitis in remission. Nutrition 2008;24:694-702.
    • (2008) Nutrition , vol.24 , pp. 694-702
    • Valentini, L.1    Schaper, L.2    Buning, C.3    Hengstermann, S.4    Koernicke, T.5    Tillinger, W.6
  • 61
    • 84883150831 scopus 로고    scopus 로고
    • The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells
    • Farrugia G, Balzan R. The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells. Oxid Med Cell Longev 2013: 504230.
    • (2013) Oxid Med Cell Longev , pp. 504230
    • Farrugia, G.1    Balzan, R.2
  • 62
    • 0347991877 scopus 로고    scopus 로고
    • The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients
    • Colombel JF, Loftus EV Jr, Tremain WJ, Egan LJ, Harmsen WS, Schleck CD, et al. The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients. Gastroenterology 2004;126:19-31.
    • (2004) Gastroenterology , vol.126 , pp. 19-31
    • Colombel, J.F.1    Loftus, E.V.2    Tremain, W.J.3    Egan, L.J.4    Harmsen, W.S.5    Schleck, C.D.6
  • 63
    • 0019986916 scopus 로고
    • Metabolic, membrane and functional responses of human polymorphonuclear leukocytes to platelet-activating factor
    • Ingraham LM, Coates TD, Allen JM, Higgins CP, Baehner RL, Boxer LA. Metabolic, membrane and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. Blood 1982;59:1259-66.
    • (1982) Blood , vol.59 , pp. 1259-1266
    • Ingraham, L.M.1    Coates, T.D.2    Allen, J.M.3    Higgins, C.P.4    Baehner, R.L.5    Boxer, L.A.6
  • 64
    • 0021352632 scopus 로고
    • Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease
    • Sharon P, Stenson WF. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 1984;86:453-60.
    • (1984) Gastroenterology , vol.86 , pp. 453-460
    • Sharon, P.1    Stenson, W.F.2
  • 65
    • 0023713281 scopus 로고
    • Active oxygen species generated by monocytes and polymorphonuclear leukocytes in Crohn's disease
    • Kitahora T, Suzuki K, Asakura H, Yoshida T, Suematsu M, Watanabe M, et al. Active oxygen species generated by monocytes and polymorphonuclear leukocytes in Crohn's disease. Dig Dis Sci 1988;33:951-5.
    • (1988) Dig Dis Sci , vol.33 , pp. 951-955
    • Kitahora, T.1    Suzuki, K.2    Asakura, H.3    Yoshida, T.4    Suematsu, M.5    Watanabe, M.6
  • 66
    • 7144253803 scopus 로고    scopus 로고
    • Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
    • Kimura H, Hokari R, Miura S, Shigematsu T, Hirokawa M, Akiba Y, et al. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 1998;42:180-7.
    • (1998) Gut , vol.42 , pp. 180-187
    • Kimura, H.1    Hokari, R.2    Miura, S.3    Shigematsu, T.4    Hirokawa, M.5    Akiba, Y.6
  • 68
    • 0022297975 scopus 로고
    • Neutrophil oxygen reduction: The enzymes and the products
    • Tauber AI, Babior BM. Neutrophil oxygen reduction: The enzymes and the products. Adv Free Radical Biol Med 1985;1:265-307.
    • (1985) Adv Free Radical Biol Med , vol.1 , pp. 265-307
    • Tauber, A.I.1    Babior, B.M.2
  • 69
    • 0022486111 scopus 로고
    • Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils
    • Winterbourn CC. Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils. J Clin Invest 1986;78:545-50.
    • (1986) J Clin Invest , vol.78 , pp. 545-550
    • Winterbourn, C.C.1
  • 70
    • 0025305349 scopus 로고
    • Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediate destruction
    • Britigan BE, Coffman TJ, Buettner GR. Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediate destruction. J Biol Chem 1990;265:2650-6.
    • (1990) J Biol Chem , vol.265 , pp. 2650-2656
    • Britigan, B.E.1    Coffman, T.J.2    Buettner, G.R.3
  • 71
    • 0024602827 scopus 로고
    • Tissue destruction by neutrophils
    • Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-76.
    • (1989) N Engl J Med , vol.320 , pp. 365-376
    • Weiss, S.J.1
  • 72
    • 0020573713 scopus 로고
    • Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils
    • Thomas EL, Grisham MB, Jefferson MM. Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils. J Clin Invest 1983;72:441-54.
    • (1983) J Clin Invest , vol.72 , pp. 441-454
    • Thomas, E.L.1    Grisham, M.B.2    Jefferson, M.M.3
  • 73
    • 0025362233 scopus 로고
    • Effect of 5-aminosalicylic acid on ferrous sulfate-mediated damage to deoxyribose
    • Grisham MB. Effect of 5-aminosalicylic acid on ferrous sulfate-mediated damage to deoxyribose. Biochem Pharmacol 1990;39:2060-3.
    • (1990) Biochem Pharmacol , vol.39 , pp. 2060-2063
    • Grisham, M.B.1
  • 74
    • 0032831796 scopus 로고    scopus 로고
    • Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls
    • Genser D, Kang MH, Vogelsang H, Elmadfa I. Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls. Eur J Clin Nutr 1999;53:675-9.
    • (1999) Eur J Clin Nutr , vol.53 , pp. 675-679
    • Genser, D.1    Kang, M.H.2    Vogelsang, H.3    Elmadfa, I.4
  • 76
    • 1042268012 scopus 로고    scopus 로고
    • Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease
    • Forrest CM, Gould SR, Darlington LG, Stone TW. Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease. Adv Exp Med Biol 2003;527:395-400.
    • (2003) Adv Exp Med Biol , vol.527 , pp. 395-400
    • Forrest, C.M.1    Gould, S.R.2    Darlington, L.G.3    Stone, T.W.4
  • 77
    • 34247874528 scopus 로고    scopus 로고
    • Study on the correlations among disease activity index and salivary transforming growth factor-β1 and nitric oxide in ulcerative colitis patients
    • Rezaie A, Khalaj S, Shabihkhani M, Nikfar S, Zamani M et al. Study on the Correlations among Disease Activity Index and Salivary Transforming Growth Factor-β1 and Nitric Oxide in Ulcerative Colitis Patients. An NY Acad Sci 2007;1095:305-14.
    • (2007) An NY Acad Sci , vol.1095 , pp. 305-314
    • Rezaie, A.1    Khalaj, S.2    Shabihkhani, M.3    Nikfar, S.4    Zamani, M.5
  • 79
    • 0031898659 scopus 로고    scopus 로고
    • Glutathione content of colonic mucosa: Evidence for oxidative damage in active ulcerative colitis
    • Holmes EW, Yong SL, Eiznhamer D, Keshavarzian A. Glutathione content of colonic mucosa: Evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci 1998;43:1088-95.
    • (1998) Dig Dis Sci , vol.43 , pp. 1088-1095
    • Holmes, E.W.1    Yong, S.L.2    Eiznhamer, D.3    Keshavarzian, A.4
  • 80
    • 33947609783 scopus 로고    scopus 로고
    • Alterations in salivary antioxidants, nitric oxide, and transforming growth factor-beta1 in relation to disease activity in Crohn's disease patients
    • Rezaie A, Ghorbani F, Eshghtork A, Zamani MJ, Dehghan G, Taghavi B, et al. Alterations in salivary antioxidants, nitric oxide, and transforming growth factor-beta1 in relation to disease activity in Crohn's disease patients. Ann N Y Acad Sci 2006;1091:110-22.
    • (2006) Ann N y Acad Sci , vol.1091 , pp. 110-122
    • Rezaie, A.1    Ghorbani, F.2    Eshghtork, A.3    Zamani, M.J.4    Dehghan, G.5    Taghavi, B.6
  • 81
    • 84886014303 scopus 로고    scopus 로고
    • Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics
    • Pastorelli L, De Salvo C, Mercado JR, Vecchi M, Pizarro TT. Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics. Front Immunol 2013;4:280.
    • (2013) Front Immunol , vol.4 , pp. 280
    • Pastorelli, L.1    De Salvo, C.2    Mercado, J.R.3    Vecchi, M.4    Pizarro, T.T.5
  • 83
    • 84891815184 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Pathogenesis
    • Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol 2014;20:91-9.
    • (2014) World J Gastroenterol , vol.20 , pp. 91-99
    • Zhang, Y.Z.1    Li, Y.Y.2
  • 84
    • 80051498495 scopus 로고    scopus 로고
    • Innate and adaptive immunity in inflammatory bowel disease
    • Siegmund B, Zeitz M. Innate and adaptive immunity in inflammatory bowel disease. World J Gastroenterol 2011;17:3178-83.
    • (2011) World J Gastroenterol , vol.17 , pp. 3178-3183
    • Siegmund, B.1    Zeitz, M.2
  • 85
    • 77956499693 scopus 로고    scopus 로고
    • Innate antimicrobial immunity in inflammatory bowel diseases
    • Beisner J, Stange EF, Wehkamp J. Innate antimicrobial immunity in inflammatory bowel diseases. Expert Rev Clin Immunol 2010;6:809-18.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 809-818
    • Beisner, J.1    Stange, E.F.2    Wehkamp, J.3
  • 87
    • 84955470193 scopus 로고    scopus 로고
    • Immunoregulation in the gut: Success and failures in human disease
    • Monteleone I, Vavassori P, Biancone L, Monteleone G, Pallone F. Immunoregulation in the gut: Success and failures in human disease. Gut 2003;50(Suppl 3):360-4.
    • (2003) Gut , vol.50 , pp. 360-364
    • Monteleone, I.1    Vavassori, P.2    Biancone, L.3    Monteleone, G.4    Pallone, F.5
  • 90
    • 84882433613 scopus 로고    scopus 로고
    • Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
    • Coskun M, Salem M, Pedersen J, Nielsen OH. Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease. Pharmacol Res 2013;76:1-8.
    • (2013) Pharmacol Res , vol.76 , pp. 1-8
    • Coskun, M.1    Salem, M.2    Pedersen, J.3    Nielsen, O.H.4
  • 91
  • 92
    • 10344264959 scopus 로고    scopus 로고
    • Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease
    • Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 1996;41:2078-86.
    • (1996) Dig Dis Sci , vol.41 , pp. 2078-2086
    • Lih-Brody, L.1    Powell, S.R.2    Collier, K.P.3    Reddy, G.M.4    Cerchia, R.5    Kahn, E.6
  • 93
    • 0031038034 scopus 로고    scopus 로고
    • Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine
    • Chiarpotto E, Scavazza A, Leonarduzzi G, Camandola S, Biasi F, Teggia PM, et al. Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine. Free Radic Biol Med 1996;22:889-94.
    • (1996) Free Radic Biol Med , vol.22 , pp. 889-894
    • Chiarpotto, E.1    Scavazza, A.2    Leonarduzzi, G.3    Camandola, S.4    Biasi, F.5    Teggia, P.M.6
  • 94
    • 13644265626 scopus 로고    scopus 로고
    • Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases
    • Jahanshahi G, Motavasel V, Rezaie A, Hashtroudi AA, Daryani NE, Abdollahi M. Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases. Dig Dis Sci 2004;49:1752-7.
    • (2004) Dig Dis Sci , vol.49 , pp. 1752-1757
    • Jahanshahi, G.1    Motavasel, V.2    Rezaie, A.3    Hashtroudi, A.A.4    Daryani, N.E.5    Abdollahi, M.6
  • 95
    • 70349787149 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB reflects clinical, inflammatory and angiogenic disease activity and oxidative stress in inflammatory bowel disease
    • Krzystek-Korpacka M, Neubauer K, Matusiewicz M. Platelet-derived growth factor-BB reflects clinical, inflammatory and angiogenic disease activity and oxidative stress in inflammatory bowel disease. Clin Biochem 2009;42:1602-9.
    • (2009) Clin Biochem , vol.42 , pp. 1602-1609
    • Krzystek-Korpacka, M.1    Neubauer, K.2    Matusiewicz, M.3
  • 98
    • 0033999250 scopus 로고    scopus 로고
    • Altered lipid proflle, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn disease
    • Levy E, Rizwan Y, Thibault L, Lepage G, Brunet S, Bouthillier L, et al. Altered lipid proflle, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn disease. Am J Clin Nutr 2000;71:807-15.
    • (2000) Am J Clin Nutr , vol.71 , pp. 807-815
    • Levy, E.1    Rizwan, Y.2    Thibault, L.3    Lepage, G.4    Brunet, S.5    Bouthillier, L.6
  • 99
    • 0034753659 scopus 로고    scopus 로고
    • Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease
    • D'Odorico A, Bortolan S, Cardin R, D'Inca R, Martines D, Ferronato A, et al. Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 2001;36:1289-94.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 1289-1294
    • Dodorico, A.1    Bortolan, S.2    Cardin, R.3    Dinca, R.4    Martines, D.5    Ferronato, A.6
  • 100
    • 0036817358 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease
    • Tuzun A, Erdil A, Inal V, Aydin A, Baʇci S, Yeşilova Z, et al. Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clin Biochem 2002;35:569-72.
    • (2002) Clin Biochem , vol.35 , pp. 569-572
    • Tuzun, A.1    Erdil, A.2    Inal, V.3    Aydin, A.4    Baʇci, S.5    Yeşilova, Z.6
  • 101
    • 84884894366 scopus 로고    scopus 로고
    • Kynurenine pathway metabolites: Relevant to Vitamin B-6 deficiency and beyond
    • Ciorba MA. Kynurenine pathway metabolites: Relevant to vitamin B-6 deficiency and beyond. Am J Clin Nutr 2013;98:863-4.
    • (2013) Am J Clin Nutr , vol.98 , pp. 863-864
    • Ciorba, M.A.1
  • 102
    • 61849182122 scopus 로고    scopus 로고
    • Tryptophan degradation in irritable bowel syndrome: Evidence of indoleamine 2,3-dioxygenase activation in a male cohort
    • Clarke G, Fitzgerald P, Cryan JF, Cassidy EM, Quigley EM, Dinan TG. Tryptophan degradation in irritable bowel syndrome: Evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol 2009;9:6.
    • (2009) BMC Gastroenterol , vol.9 , pp. 6
    • Clarke, G.1    Fitzgerald, P.2    Cryan, J.F.3    Cassidy, E.M.4    Quigley, E.M.5    Dinan, T.G.6
  • 103
    • 0036808473 scopus 로고    scopus 로고
    • Oxidative stress, Vitamin A and Vitamin E behaviour in patients submitted to conservative surgery for complicated Crohn's disease
    • Sampietro GM, Cristaldi M, Cervato G, Maconi G, Danelli P, Cervellione R, et al. Oxidative stress, vitamin A and vitamin E behaviour in patients submitted to conservative surgery for complicated Crohn's disease. Dig Liver Dis 2010;34:696-701.
    • (2010) Dig Liver Dis , vol.34 , pp. 696-701
    • Sampietro, G.M.1    Cristaldi, M.2    Cervato, G.3    Maconi, G.4    Danelli, P.5    Cervellione, R.6
  • 104
    • 0141884297 scopus 로고    scopus 로고
    • Decreased oxidative stress in patients with ulcerative colitis supplemented with flsh oil omega-3 fatty acids
    • Barbosa DS, Cecchini R, El Kadri MZ, Rodríguez MA, Burini RC, Dichi I. Decreased oxidative stress in patients with ulcerative colitis supplemented with flsh oil omega-3 fatty acids. Nutrition 2003;19:837-42.
    • (2003) Nutrition , vol.19 , pp. 837-842
    • Barbosa, D.S.1    Cecchini, R.2    El Kadri, M.Z.3    Rodríguez, M.A.4    Burini, R.C.5    Dichi, I.6
  • 105
    • 84902193934 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidant defence in ulcerative colitis patients from north India
    • Rana SV, Sharma S, Prasad KK, Sinha SK, Singh K. Role of oxidative stress and antioxidant defence in ulcerative colitis patients from north India. Indian J Med Res 2014;139:568-71.
    • (2014) Indian J Med Res , vol.139 , pp. 568-571
    • Rana, S.V.1    Sharma, S.2    Prasad, K.K.3    Sinha, S.K.4    Singh, K.5
  • 106
    • 0038449206 scopus 로고    scopus 로고
    • Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation
    • Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation. Gastroenterology 2003;125:58-69.
    • (2003) Gastroenterology , vol.125 , pp. 58-69
    • Hatoum, O.A.1    Binion, D.G.2    Otterson, M.F.3    Gutterman, D.D.4
  • 108
    • 58649115401 scopus 로고    scopus 로고
    • Is Inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease
    • Binion DG, Rafiee P. Is Inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease. Gastroenterology 2009;136:400-3.
    • (2009) Gastroenterology , vol.136 , pp. 400-403
    • Binion, D.G.1    Rafiee, P.2
  • 109
    • 0141626704 scopus 로고    scopus 로고
    • Intestinal oxidative damage in inflammatory bowel disease: Semi-quantiflcation, localization, and association with mucosal antioxidants
    • Kruidenier L, Kuiper I, Lamers CB, Verspaget HW. Intestinal oxidative damage in inflammatory bowel disease: Semi-quantiflcation, localization, and association with mucosal antioxidants. J Pathol 2003;201:28-36.
    • (2003) J Pathol , vol.201 , pp. 28-36
    • Kruidenier, L.1    Kuiper, I.2    Lamers, C.B.3    Verspaget, H.W.4
  • 110
    • 0036667555 scopus 로고    scopus 로고
    • Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
    • Zelko IN, Mariani TJ, Folz RJ. Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 2002;33:337-49.
    • (2002) Free Radic Biol Med , vol.33 , pp. 337-349
    • Zelko, I.N.1    Mariani, T.J.2    Folz, R.J.3
  • 111
    • 35348982262 scopus 로고    scopus 로고
    • Mouse models of inflammatory bowel disease
    • Wirtz S, Neurath MF. Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev 2007;59:1073-83.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1073-1083
    • Wirtz, S.1    Neurath, M.F.2
  • 115
    • 84901786188 scopus 로고    scopus 로고
    • Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron
    • Triantafillidis JK, Douvi G, Agrogiannis G, Patsouris E, Gikas A, Papalois AE. Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron. Biomed Res Int 2014;2014:648535.
    • (2014) Biomed Res Int , vol.2014 , pp. 648535
    • Triantafillidis, J.K.1    Douvi, G.2    Agrogiannis, G.3    Patsouris, E.4    Gikas, A.5    Papalois, A.E.6
  • 116
    • 0036238027 scopus 로고    scopus 로고
    • Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis
    • Tham DM, Whitin JC, Cohen HJ. Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis. Pediatr Res 2002;51:641-6.
    • (2002) Pediatr Res , vol.51 , pp. 641-646
    • Tham, D.M.1    Whitin, J.C.2    Cohen, H.J.3
  • 117
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 2003;94:965-73.
    • (2003) Cancer Sci , vol.94 , pp. 965-973
    • Tanaka, T.1    Kohno, H.2    Suzuki, R.3    Yamada, Y.4    Sugie, S.5    Mori, H.6
  • 118
    • 33746176093 scopus 로고    scopus 로고
    • Biochemical and histopathological evidences for beneflcial effects of Satureja Khuzestanica Jamzad essential oil on the mouse model of inflammatory bowel diseases
    • Ghazanfari G, Minaie B, Yasa N, Nakhai LA, Mohammadirad A, Nikfar S, et al. Biochemical and histopathological evidences for beneflcial effects of Satureja Khuzestanica Jamzad essential oil on the mouse model of inflammatory bowel diseases. Toxicol Mech Methods 2007;16:365-72.
    • (2007) Toxicol Mech Methods , vol.16 , pp. 365-372
    • Ghazanfari, G.1    Minaie, B.2    Yasa, N.3    Nakhai, L.A.4    Mohammadirad, A.5    Nikfar, S.6
  • 119
    • 33746025241 scopus 로고    scopus 로고
    • Protection by Ziziphora clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity
    • Ghafari H, Yasa N, Mohammadirad A, Dehghan G, Zamani MJ, Nikfar S, et al. Protection by Ziziphora clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity. Hum Exp Toxicol 2006;25:325-32.
    • (2006) Hum Exp Toxicol , vol.25 , pp. 325-332
    • Ghafari, H.1    Yasa, N.2    Mohammadirad, A.3    Dehghan, G.4    Zamani, M.J.5    Nikfar, S.6
  • 120
    • 17744371147 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease
    • Ding X, Hiraku Y, Ma N, Kato T, Saito K, Nagahama M, et al. Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease. Cancer Sci 2005;96:157-63.
    • (2005) Cancer Sci , vol.96 , pp. 157-163
    • Ding, X.1    Hiraku, Y.2    Ma, N.3    Kato, T.4    Saito, K.5    Nagahama, M.6
  • 121
    • 0033790175 scopus 로고    scopus 로고
    • A new chronic ulcerative colitis model produced by combined methods in rats
    • Jiang XL, Cui HF. A new chronic ulcerative colitis model produced by combined methods in rats. World J Gastroenterol 2000;6:742-6.
    • (2000) World J Gastroenterol , vol.6 , pp. 742-746
    • Jiang, X.L.1    Cui, H.F.2
  • 122
    • 32044473062 scopus 로고    scopus 로고
    • Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells
    • Mizoguchi E. Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology 2006;130:398-411.
    • (2006) Gastroenterology , vol.130 , pp. 398-411
    • Mizoguchi, E.1
  • 124
    • 80054843370 scopus 로고    scopus 로고
    • Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease
    • Jensen SR, Fink LN, Nielsen OH, Brynskov J, Brix S. Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease. Microb Pathog 2011;51:426-31.
    • (2011) Microb Pathog , vol.51 , pp. 426-431
    • Jensen, S.R.1    Fink, L.N.2    Nielsen, O.H.3    Brynskov, J.4    Brix, S.5
  • 125
    • 84883166207 scopus 로고    scopus 로고
    • Chitin-binding domains of Escherichia coli chiA mediates interactions with intestinal epithelial cells in mice with colitis
    • Low D, Tran HT, Lee IA, Dreux N, Kamba A, Reinecker HC, et al. Chitin-binding domains of Escherichia coli chiA mediates interactions with intestinal epithelial cells in mice with colitis. Gastroenterology 2013;145:602-12.e9.
    • (2013) Gastroenterology , vol.145 , pp. 602-602e9
    • Low, D.1    Tran, H.T.2    Lee, I.A.3    Dreux, N.4    Kamba, A.5    Reinecker, H.C.6
  • 127
    • 0028092051 scopus 로고
    • Antioxidant properties of aminosalicylates
    • Miles AM, Grisham MB. Antioxidant properties of aminosalicylates. Methods Enzymol 1994;234:555-72.
    • (1994) Methods Enzymol , vol.234 , pp. 555-572
    • Miles, A.M.1    Grisham, M.B.2
  • 129
    • 16544370153 scopus 로고    scopus 로고
    • Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease
    • Trebble TM, Arden NK, Wootton SA, Calder PC, Mullee MA, Fine DR, et al. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr 2004;80:1137-44.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1137-1144
    • Trebble, T.M.1    Arden, N.K.2    Wootton, S.A.3    Calder, P.C.4    Mullee, M.A.5    Fine, D.R.6
  • 130
    • 25444492604 scopus 로고    scopus 로고
    • High-dose flsh oil and antioxidants in Crohn's disease and the response of bone turnover: A randomised controlled trial
    • Trebble TM, Stroud MA, Wootton SA, Calder PC, Fine DR, Mullee MA, et al. High-dose flsh oil and antioxidants in Crohn's disease and the response of bone turnover: A randomised controlled trial. Br J Nutr 2005;94:253-61.
    • (2005) Br J Nutr , vol.94 , pp. 253-261
    • Trebble, T.M.1    Stroud, M.A.2    Wootton, S.A.3    Calder, P.C.4    Fine, D.R.5    Mullee, M.A.6
  • 131
    • 0034181512 scopus 로고    scopus 로고
    • Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid proflle
    • Geerling BJ, Badart-Smook A, van Deursen C, van Houwelingen AC, Russel MG, Stockbrügger RW, et al. Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn's disease in remission: Effects on antioxidant status and fatty acid proflle. Inflamm Bowel Dis 2000;6:77-84.
    • (2000) Inflamm Bowel Dis , vol.6 , pp. 77-84
    • Geerling, B.J.1    Badart-Smook, A.2    Van Deursen, C.3    Van Houwelingen, A.C.4    Russel, M.G.5    Stockbrügger, R.W.6
  • 132
    • 20144389026 scopus 로고    scopus 로고
    • An oral supplement enriched with flsh oil, soluble flber, and antioxidants for corticosteroid sparing in ulcerative colitis: A randomized, controlled trial
    • Seidner DL, Lashner BA, Brzezinski A, Banks PL, Goldblum J, Fiocchi C, et al. An oral supplement enriched with flsh oil, soluble flber, and antioxidants for corticosteroid sparing in ulcerative colitis: A randomized, controlled trial. Clin Gastroenterol Hepatol 2004;3:358-69.
    • (2004) Clin Gastroenterol Hepatol , vol.3 , pp. 358-369
    • Seidner, D.L.1    Lashner, B.A.2    Brzezinski, A.3    Banks, P.L.4    Goldblum, J.5    Fiocchi, C.6
  • 135
    • 40849102807 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid
    • Ran ZH, Chen C, Xiao SD. Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid. Biomed Pharmacother 2008;62:189-96.
    • (2008) Biomed Pharmacother , vol.62 , pp. 189-196
    • Zh, R.1    Chen, C.2    Xiao, S.D.3
  • 136
    • 84856728144 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis
    • Brückner M, Westphal S, Domschke W, Kucharzik T, Lügering A. Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. J Crohns Colitis 2012;6:226-35.
    • (2012) J Crohns Colitis , vol.6 , pp. 226-235
    • Brückner, M.1    Westphal, S.2    Domschke, W.3    Kucharzik, T.4    Lügering, A.5
  • 137
    • 37849187686 scopus 로고    scopus 로고
    • Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
    • Hagar HH, Medany A, El Eter E, Araf M. Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats. Eur J Pharmacol 2007;554:69-77.
    • (2007) Eur J Pharmacol , vol.554 , pp. 69-77
    • Hagar, H.H.1    Medany, A.2    El Eter, E.3    Araf, M.4
  • 138
    • 37349124150 scopus 로고    scopus 로고
    • Protective effects of 2, 3, 5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice
    • Wang X, Zhao L, Han T, Chen S, Wang J. Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. Eur J Pharmacol 2008;578:339-48.
    • (2008) Eur J Pharmacol , vol.578 , pp. 339-348
    • Wang, X.1    Zhao, L.2    Han, T.3    Chen, S.4    Wang, J.5
  • 139
    • 84856089700 scopus 로고    scopus 로고
    • Parthenolide, an inhibitor of the nuclear factor-kB pathway, ameliorates dextran sulfate sodium-induced colitis in mice
    • Zhao ZJ, Xiang JY, Liu L, Huang XL, Gan HT. Parthenolide, an inhibitor of the nuclear factor-kB pathway, ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunopharmacol 2012;12:169-74.
    • (2012) Int Immunopharmacol , vol.12 , pp. 169-174
    • Zhao, Z.J.1    Xiang, J.Y.2    Liu, L.3    Huang, X.L.4    Gan, H.T.5
  • 140
    • 84863044754 scopus 로고    scopus 로고
    • A novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice
    • Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Gotoa R, et al. A novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. J Crohns Colitis 2012;6:215-25.
    • (2012) J Crohns Colitis , vol.6 , pp. 215-225
    • Funakoshi, T.1    Yamashita, K.2    Ichikawa, N.3    Fukai, M.4    Suzuki, T.5    Gotoa, R.6
  • 141
    • 84881048250 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
    • Dashdorj A, Jyothi KR, Lim S, Jo A, Nguyen MN, Ha J, et al. Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. BMC Med 2013;11:178.
    • (2013) BMC Med , vol.11 , pp. 178
    • Dashdorj, A.1    Jyothi, K.R.2    Lim, S.3    Jo, A.4    Nguyen, M.N.5    Ha, J.6
  • 144
    • 80054850976 scopus 로고    scopus 로고
    • Polyphenol supplementation as a complementary medicinal approach to treating inflammatory bowel disease
    • Biasi F, Astegiano M, Maina M, Leonarduzzi G, Poli G. Polyphenol supplementation as a complementary medicinal approach to treating inflammatory bowel disease. Curr Med Chem 2014;18:4851-65.
    • (2014) Curr Med Chem , vol.18 , pp. 4851-4865
    • Biasi, F.1    Astegiano, M.2    Maina, M.3    Leonarduzzi, G.4    Poli, G.5
  • 145
    • 34047191288 scopus 로고    scopus 로고
    • Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis
    • Shapiro H, Singer P, Halpern Z, Bruck R. Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut 2007;56:426-35.
    • (2007) Gut , vol.56 , pp. 426-435
    • Shapiro, H.1    Singer, P.2    Halpern, Z.3    Bruck, R.4
  • 146
    • 70349562760 scopus 로고    scopus 로고
    • Dietary polyphenols can modulate the intestinal inflammatory response
    • Romier B, Schneider YJ, Larondelle Y, During A. Dietary polyphenols can modulate the intestinal inflammatory response. Nutr Rev 2007;67:363-78.
    • (2007) Nutr Rev , vol.67 , pp. 363-378
    • Romier, B.1    Schneider, Y.J.2    Larondelle, Y.3    During, A.4
  • 147
    • 84875945544 scopus 로고    scopus 로고
    • Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD)
    • Mueller D, Triebel S, Rudakovski O, Richling E. Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD). Food Chem 2013;139:339-46.
    • (2013) Food Chem , vol.139 , pp. 339-346
    • Mueller, D.1    Triebel, S.2    Rudakovski, O.3    Richling, E.4
  • 148
    • 84866926742 scopus 로고    scopus 로고
    • The endocannabinoid system in inflammatory bowel diseases: From pathophysiology to therapeutic opportunity
    • Alhouayek M, Muccioli GG. The endocannabinoid system in inflammatory bowel diseases: From pathophysiology to therapeutic opportunity. Trends Mol Med 2012;18:615-25.
    • (2012) Trends Mol Med , vol.18 , pp. 615-625
    • Alhouayek, M.1    Muccioli, G.G.2
  • 149
    • 84875726038 scopus 로고    scopus 로고
    • Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
    • Borrelli F, Fasolino I, Romano B, Capasso R, Maiello F, Coppola D, et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochem Pharmacol 2013;85:1306-16.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1306-1316
    • Borrelli, F.1    Fasolino, I.2    Romano, B.3    Capasso, R.4    Maiello, F.5    Coppola, D.6


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