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Volumn 24, Issue 7, 2009, Pages 1169-1178

Rescue strategies against non-steroidal anti-inflammatory drug-induced gastroduodenal damage

Author keywords

Cyclooxygenase; Gastroduodenal damage; Non steroidal anti inflammatory drug; Safety

Indexed keywords

ACEXAMATE ZINC; ACTIVATING TRANSCRIPTION FACTOR 6; CELECOXIB; CYCLOOXYGENASE 2; DEOXYRIBONUCLEASE I; DICLOFENAC; DP 155; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; HYDROGEN SULFIDE; IBUPROFEN; ICOSANOID; INDOMETACIN; INOSITOL; INTERCELLULAR ADHESION MOLECULE 1; LEUKOTRIENE B4; LICOFELONE; LIPOXIN A; MEFENAMIC ACID; NITRIC OXIDE DONOR; NITROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIROXICAM; POLAPREZINC; ROFECOXIB; SILDENAFIL; TENOXICAM; TEPOXALIN; TEPRENONE; UNCLASSIFIED DRUG; ZINC;

EID: 68749085157     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.05929.x     Document Type: Review
Times cited : (33)

References (97)
  • 1
    • 41349112480 scopus 로고    scopus 로고
    • NSAIDs, risks, and gastroprotective strategies: Current status and future
    • Graham DY, Chan FKL. NSAIDs, risks, and gastroprotective strategies: current status and future. Gastroenterology 2008 134 : 1240 57.
    • (2008) Gastroenterology , vol.134 , pp. 1240-1257
    • Graham, D.Y.1    Chan, F.K.L.2
  • 2
    • 0031042347 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
    • Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997 112 : 1000 18.
    • (1997) Gastroenterology , vol.112 , pp. 1000-1018
    • Wallace, J.L.1
  • 3
    • 0030338041 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug gastropathy: Causes and treatment
    • Suppl
    • Hawkey CJ. Non-steroidal anti-inflammatory drug gastropathy: causes and treatment. Scand. J. Gastroenterol. 1996 31 (Suppl 124 7.
    • (1996) Scand. J. Gastroenterol. , vol.31 , Issue.124 , pp. 7
    • Hawkey, C.J.1
  • 4
    • 0033863020 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug gastropathy
    • Hawkey CJ. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000 119 : 521 35.
    • (2000) Gastroenterology , vol.119 , pp. 521-535
    • Hawkey, C.J.1
  • 5
    • 0035143820 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions
    • Russell RI. Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions. Postgrad. Med. J. 2001 77 : 82 8.
    • (2001) Postgrad. Med. J. , vol.77 , pp. 82-88
    • Russell, R.I.1
  • 6
    • 0031053145 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: New insights into an old problem
    • Davies NM, Wallace JL. Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem. J. Gastroenterol. 1997 32 : 127 33.
    • (1997) J. Gastroenterol. , vol.32 , pp. 127-133
    • Davies, N.M.1    Wallace, J.L.2
  • 7
    • 0032579890 scopus 로고    scopus 로고
    • Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury
    • Griffin MR. Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury. Am. J. Med. 1998 104 : 23S 29S.
    • (1998) Am. J. Med. , vol.104
    • Griffin, M.R.1
  • 8
    • 0029120106 scopus 로고
    • Nonsteroidal anti-inflamatory drugs and dyspepsia in the elderly
    • Talley NJ, Evans JM, Fleming KC et al. Nonsteroidal anti-inflamatory drugs and dyspepsia in the elderly. Dig. Dis. Sci. 1995 40 : 1345 50.
    • (1995) Dig. Dis. Sci. , vol.40 , pp. 1345-1350
    • Talley, N.J.1    Evans, J.M.2    Fleming, K.C.3
  • 9
    • 41349090797 scopus 로고    scopus 로고
    • The relative efficacies of gastroprotective strategies in chronic users of nonsteroidal anti-inflammatory drugs
    • Targownik LE, Metge CJ, Leung S et al. The relative efficacies of gastroprotective strategies in chronic users of nonsteroidal anti-inflammatory drugs. Gastroenterology 2008 134 : 937 44.
    • (2008) Gastroenterology , vol.134 , pp. 937-944
    • Targownik, L.E.1    Metge, C.J.2    Leung, S.3
  • 10
    • 34447122624 scopus 로고    scopus 로고
    • Risk of upper gastrointestinal events with the use of various NSAIDs; A case-control study in a general population
    • Helin-Salmivaara A, Saarelainen S, Gronroos JM et al. Risk of upper gastrointestinal events with the use of various NSAIDs; a case-control study in a general population. Scand. J. Gastroenterol. 2007 42 : 923 32.
    • (2007) Scand. J. Gastroenterol. , vol.42 , pp. 923-932
    • Helin-Salmivaara, A.1    Saarelainen, S.2    Gronroos, J.M.3
  • 11
    • 46049093776 scopus 로고    scopus 로고
    • Gastric mucosal defense and cytoprotection: Bench to bedside
    • Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008 135 : 41 60.
    • (2008) Gastroenterology. , vol.135 , pp. 41-60
    • Laine, L.1    Takeuchi, K.2    Tarnawski, A.3
  • 12
    • 0009654998 scopus 로고
    • Nonsteroidal anti-inflammatory drugs; How do they damage gastroduodenal mucosa?
    • Suppl.
    • Scarpignato C. Nonsteroidal anti-inflammatory drugs; How do they damage gastroduodenal mucosa? Dig. Dis. 1995 13 (Suppl. 1 9 39.
    • (1995) Dig. Dis. , vol.13 , Issue.1 , pp. 9-39
    • Scarpignato, C.1
  • 13
    • 0028477737 scopus 로고
    • NSAID-induced peptic ulcer disease; A critical review of pathogenesis and treatment
    • Scheiman JM. NSAID-induced peptic ulcer disease; a critical review of pathogenesis and treatment. Dig. Dis. 1994 12 : 210 22.
    • (1994) Dig. Dis. , vol.12 , pp. 210-222
    • Scheiman, J.M.1
  • 14
    • 0035109918 scopus 로고    scopus 로고
    • The impact of nonsteroidal anti-inflammatory drug-induced gastropathy
    • Scheiman JM. The impact of nonsteroidal anti-inflammatory drug-induced gastropathy. Am. J. Manag. Care. 2001 7 : S10 14.
    • (2001) Am. J. Manag. Care. , vol.7 , pp. 10-14
    • Scheiman, J.M.1
  • 15
    • 0018149850 scopus 로고
    • The effects of aspirin and other non-steriodal anti-inflammatory/ analgesic drugs on gastrointestinal mucus glycoprotein biosynthesis in vivo: Relationship to ulcerogenic action
    • Rainsford KD. The effects of aspirin and other non-steriodal anti-inflammatory/analgesic drugs on gastrointestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic action. Biochem. Pharmacol. 1978 27 : 877 85.
    • (1978) Biochem. Pharmacol. , vol.27 , pp. 877-885
    • Rainsford, K.D.1
  • 16
    • 0021962497 scopus 로고
    • Focal gastric mucosal blood flow at the site of aspirin-induced ulceration
    • Ashley SW, Sonnenschein LA, Cheung LY. Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. Am. J. Surg. 1985 149 : 53 9.
    • (1985) Am. J. Surg. , vol.149 , pp. 53-59
    • Ashley, S.W.1    Sonnenschein, L.A.2    Cheung, L.Y.3
  • 17
    • 33751436594 scopus 로고    scopus 로고
    • Mucosal acid causes gastric mucosal microcirculatory disturbance in nonsteroidal anti-inflammatory drug-treated rats
    • Funatsu T, Chono K, Hirata T, Keto Y, Kimoto A, Sasamata M. Mucosal acid causes gastric mucosal microcirculatory disturbance in nonsteroidal anti-inflammatory drug-treated rats. Eur. J. Pharmacol. 2007 554 : 53 9.
    • (2007) Eur. J. Pharmacol. , vol.554 , pp. 53-59
    • Funatsu, T.1    Chono, K.2    Hirata, T.3    Keto, Y.4    Kimoto, A.5    Sasamata, M.6
  • 19
    • 0033862189 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 inhibitors suppress epithelial cell kinetics and delay gastric wound healing in rats
    • Sun WH, Tsuji S, Tsuji M et al. Cyclo-oxygenase-2 inhibitors suppress epithelial cell kinetics and delay gastric wound healing in rats. J. Gastroenterol. Hepatol. 2000 15 : 752 61.
    • (2000) J. Gastroenterol. Hepatol. , vol.15 , pp. 752-761
    • Sun, W.H.1    Tsuji, S.2    Tsuji, M.3
  • 20
    • 84895695013 scopus 로고
    • Does aspirin damage the stomach by decreasing gastric mucosal surface hydrophobicity?
    • Goddard PJ, Hills BA, Lichtenberger LM. Does aspirin damage the stomach by decreasing gastric mucosal surface hydrophobicity? Gastroenterology 1985 88 : 1714.
    • (1985) Gastroenterology , vol.88 , pp. 1714
    • Goddard, P.J.1    Hills, B.A.2    Lichtenberger, L.M.3
  • 21
    • 33751226593 scopus 로고    scopus 로고
    • NSAID injury to the gastrointestinal track; Evidence that NSAIDs interact with phospholipids to weaken hydrophobic surface barrier and induce formation of unstable pores in membranes
    • Lichtenberger LM, Zhou Y, Dial EJ, Raphael RM. NSAID injury to the gastrointestinal track; evidence that NSAIDs interact with phospholipids to weaken hydrophobic surface barrier and induce formation of unstable pores in membranes. J. Pharm. Pharmacol. 2006 58 : 1421 8.
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 1421-1428
    • Lichtenberger, L.M.1    Zhou, Y.2    Dial, E.J.3    Raphael, R.M.4
  • 22
    • 0034946873 scopus 로고    scopus 로고
    • Cyclooxygenase-selective inhibition of prostanoid formation: Transducing biochemical selectivity into clinical read-outs
    • Patrono C, Patrignani P, Garcia Rodriguez LA. Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. J. Clin. Invest. 2001 108 : 7 13.
    • (2001) J. Clin. Invest. , vol.108 , pp. 7-13
    • Patrono, C.1    Patrignani, P.2    Garcia Rodriguez, L.A.3
  • 23
    • 0034864294 scopus 로고    scopus 로고
    • Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives
    • Halter F, Tarnawski A, Schmassmann A, Peskar BM. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 2001 49 : 443 53.
    • (2001) Gut , vol.49 , pp. 443-453
    • Halter, F.1    Tarnawski, A.2    Schmassmann, A.3    Peskar, B.M.4
  • 24
    • 0028818913 scopus 로고
    • Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
    • Dinchuk JE, Car BD, Focht RJ et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995 378 : 406 9.
    • (1995) Nature , vol.378 , pp. 406-409
    • Dinchuk, J.E.1    Car, B.D.2    Focht, R.J.3
  • 25
    • 0031978507 scopus 로고    scopus 로고
    • Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease
    • Panes J, Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology. 1998 114 : 1066 90.
    • (1998) Gastroenterology. , vol.114 , pp. 1066-1090
    • Panes, J.1    Granger, D.N.2
  • 26
    • 29244474359 scopus 로고    scopus 로고
    • NSAIDs and gastrointestinal complications; New clinical challenge
    • Abraham NS, Graham DY. NSAIDs and gastrointestinal complications; new clinical challenge. Expert. Opin. Pharmacother. 2005 6 : 2681 9.
    • (2005) Expert. Opin. Pharmacother. , vol.6 , pp. 2681-2689
    • Abraham, N.S.1    Graham, D.Y.2
  • 27
    • 0034097624 scopus 로고    scopus 로고
    • Uncoupling of intestinal mitochondrial oxidative phosphoraylation and inhibition of cyclooxygenase are required for development of NSAID-enteropathy in the rat
    • Somasundaram S, Sigthorsson G, Simpson RJ et al. Uncoupling of intestinal mitochondrial oxidative phosphoraylation and inhibition of cyclooxygenase are required for development of NSAID-enteropathy in the rat. Aliment. Pharmacol. Ther. 2000 14 : 639 50.
    • (2000) Aliment. Pharmacol. Ther. , vol.14 , pp. 639-650
    • Somasundaram, S.1    Sigthorsson, G.2    Simpson, R.J.3
  • 29
    • 0037099294 scopus 로고    scopus 로고
    • Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes
    • Basivireddy J, Vasudevan A, Jacob M, Balasubramanian KA. Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochem. Pharmacol. 2002 64 : 339 49.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 339-349
    • Basivireddy, J.1    Vasudevan, A.2    Jacob, M.3    Balasubramanian, K.A.4
  • 30
    • 0023872428 scopus 로고
    • Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats
    • Ueki S, Takeuchi K, Okabe S. Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig. Dis. Sci. 1988 33 : 209 16.
    • (1988) Dig. Dis. Sci. , vol.33 , pp. 209-216
    • Ueki, S.1    Takeuchi, K.2    Okabe, S.3
  • 31
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat. Res. 2005 569 : 29 63.
    • (2005) Mutat. Res. , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 32
    • 33846548110 scopus 로고    scopus 로고
    • ER stress and diseases
    • Yoshida H. ER stress and diseases. FEBS Lett. 2007 274 : 630 58.
    • (2007) FEBS Lett. , vol.274 , pp. 630-658
    • Yoshida, H.1
  • 33
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Diff. 2006 13 : 374 84.
    • (2006) Cell Death Diff. , vol.13 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 34
    • 0035912094 scopus 로고    scopus 로고
    • Repression of GADD153/CHOP by NF-κB: A possible cellular defense against endoplasmic reticulum stress-induced cell death
    • Nozaki S, Sledge GW, Nakshatri H. Repression of GADD153/CHOP by NF-κB: a possible cellular defense against endoplasmic reticulum stress-induced cell death. Oncogene 2001 20 : 2178 85.
    • (2001) Oncogene , vol.20 , pp. 2178-2185
    • Nozaki, S.1    Sledge, G.W.2    Nakshatri, H.3
  • 35
    • 33645216351 scopus 로고    scopus 로고
    • Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling
    • Yamazaki T, Muramoto M, Oe T et al. Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling. Neuro. Pharmacol. 2006 50 : 558 67.
    • (2006) Neuro. Pharmacol. , vol.50 , pp. 558-567
    • Yamazaki, T.1    Muramoto, M.2    Oe, T.3
  • 36
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumor development: Friend or foe
    • Ma Y, Hendershot LM. The role of the unfolded protein response in tumor development: friend or foe. Nat. Rev. Cancer 2004 4 : 966 77.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 37
    • 4544322635 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis
    • Tsutumi S, Gotoh T, Tomisato W. et al. Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis. Cell Death Differ. 2004 11 : 1009 16.
    • (2004) Cell Death Differ. , vol.11 , pp. 1009-1016
    • Tsutumi, S.1    Gotoh, T.2    Tomisato, W.3
  • 38
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 2006 86 : 1133 49.
    • (2006) Physiol. Rev. , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 39
    • 34548125720 scopus 로고    scopus 로고
    • Anti-inflammatory and side effects of cyclooxygenase inhibitors
    • Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol. Rep. 2007 59 : 247 58.
    • (2007) Pharmacol. Rep. , vol.59 , pp. 247-258
    • Suleyman, H.1    Demircan, B.2    Karagoz, Y.3
  • 40
    • 33747777758 scopus 로고    scopus 로고
    • PPARγ as a new therapeutic target in inflammatory bowel disease
    • Dubuquoy L, Rousseaux C, Thuru X et al. PPARγ as a new therapeutic target in inflammatory bowel disease. Gut 2006 55 : 1341 9.
    • (2006) Gut , vol.55 , pp. 1341-1349
    • Dubuquoy, L.1    Rousseaux, C.2    Thuru, X.3
  • 41
    • 0036839817 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor-γ is a target of non-steroidal anti-inflammatory drug mediating cyclooxygenase-independent inhibition of lung cancer cell growth
    • Wick M, Hutreau G, Dessev C et al. Peroxisome proliferators-activated receptor-γ is a target of non-steroidal anti-inflammatory drug mediating cyclooxygenase-independent inhibition of lung cancer cell growth. Mol. Pharmacol. 2002 62 : 1207 14.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1207-1214
    • Wick, M.1    Hutreau, G.2    Dessev, C.3
  • 42
    • 35748959038 scopus 로고    scopus 로고
    • Hydrogen sulphide and its therapeutic potential
    • Szabo C. Hydrogen sulphide and its therapeutic potential. Nat. Rev. Drug Discov. 2007 6 : 917 35.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 917-935
    • Szabo, C.1
  • 44
    • 0032811572 scopus 로고    scopus 로고
    • Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation
    • Masubuchi Y, Yamada S, Horie T. Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation. Biochem. Pharmacol. 1999 58 : 861 5.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 861-865
    • Masubuchi, Y.1    Yamada, S.2    Horie, T.3
  • 46
    • 33845953401 scopus 로고    scopus 로고
    • Heme oxidase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs
    • Aburaya M, Tanaka KI, Hoshino T et al. Heme oxidase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs. J. Biol. Chem. 2006 281 : 33422 32.
    • (2006) J. Biol. Chem. , vol.281 , pp. 33422-33432
    • Aburaya, M.1    Tanaka, K.I.2    Hoshino, T.3
  • 47
    • 38949193198 scopus 로고    scopus 로고
    • The involvement of heme oxidase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis
    • Horvath K, Varga C, Berko A, Posa A, Laszio F, Whittle BJR. The involvement of heme oxidase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis. Eur. J. Pharmacol. 2008 581 : 315 23.
    • (2008) Eur. J. Pharmacol. , vol.581 , pp. 315-323
    • Horvath, K.1    Varga, C.2    Berko, A.3    Posa, A.4    Laszio, F.5    Whittle, B.J.R.6
  • 48
    • 33745728329 scopus 로고    scopus 로고
    • Lipoxins and new lipid mediators in the resolution of inflammation
    • Schwab JM, Serhan CN. Lipoxins and new lipid mediators in the resolution of inflammation. Curr. Opin. Pharmacol. 2006 6 : 414 20.
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 414-420
    • Schwab, J.M.1    Serhan, C.N.2
  • 49
    • 24344469200 scopus 로고    scopus 로고
    • Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution
    • Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot. Essent. Fatty Acids 2005 73 : 141 62.
    • (2005) Prostaglandins Leukot. Essent. Fatty Acids , vol.73 , pp. 141-162
    • Serhan, C.N.1
  • 50
    • 33847144181 scopus 로고    scopus 로고
    • Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing
    • Svensson CI, Zattoni M, Serhan CN. Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J. Exp. Med. 2007 204 : 245 52.
    • (2007) J. Exp. Med. , vol.204 , pp. 245-252
    • Svensson, C.I.1    Zattoni, M.2    Serhan, C.N.3
  • 51
    • 38949153410 scopus 로고    scopus 로고
    • Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties
    • Petasis NA, Keledjian R, Sun YP et al. Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorganic. Med. Chem. Lett. 2008 18 : 1382 7.
    • (2008) Bioorganic. Med. Chem. Lett. , vol.18 , pp. 1382-1387
    • Petasis, N.A.1    Keledjian, R.2    Sun, Y.P.3
  • 52
    • 33846184714 scopus 로고    scopus 로고
    • Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat
    • Wallace JL, Caliendo G, Santagada V, Cirino G, Fiorucci S. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007 132 : 261 71.
    • (2007) Gastroenterology. , vol.132 , pp. 261-271
    • Wallace, J.L.1    Caliendo, G.2    Santagada, V.3    Cirino, G.4    Fiorucci, S.5
  • 53
    • 26844568431 scopus 로고    scopus 로고
    • Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs
    • Fiorucci S, Antonelli E, Distrutti E et al. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology. 2005 129 : 1210 24.
    • (2005) Gastroenterology. , vol.129 , pp. 1210-1224
    • Fiorucci, S.1    Antonelli, E.2    Distrutti, E.3
  • 55
    • 34047142764 scopus 로고    scopus 로고
    • 2S) the third gas of interest for pharmacologists
    • 2S) the third gas of interest for pharmacologists. Pharmacol. Reports. 2007 59 : 4 24.
    • (2007) Pharmacol. Reports. , vol.59 , pp. 4-24
    • Kowicka, E.1    Betowski, J.2
  • 56
    • 35348904437 scopus 로고    scopus 로고
    • Building a better aspirin; Gaseous solutions to a century-old problem
    • Wallace JL. Building a better aspirin; gaseous solutions to a century-old problem. Br. J. Pharmacol. 2007 152 : 421 8.
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 421-428
    • Wallace, J.L.1
  • 57
    • 68749100359 scopus 로고    scopus 로고
    • Volatile sulfure compounds as a predictor for esophagogastroduodenal mucosal injury
    • Yoo SH, Jung HS, Sohn WS et al. Volatile sulfure compounds as a predictor for esophagogastroduodenal mucosal injury. Gut. Liver 2008 2 : 113 18.
    • (2008) Gut. Liver , vol.2 , pp. 113-118
    • Yoo, S.H.1    Jung, H.S.2    Sohn, W.S.3
  • 58
    • 34047226649 scopus 로고    scopus 로고
    • Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin
    • Lichtenberger LM, Omero JJ, Dial EJ. Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin. Br. J. Pharmacol. 2007 150 : 913 19.
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 913-919
    • Lichtenberger, L.M.1    Omero, J.J.2    Dial, E.J.3
  • 60
    • 47749083511 scopus 로고    scopus 로고
    • Clinical trial: Comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients
    • Lanza FL, Marathi UK, Arand BS, Lichtenbergers LM. Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients. Aliment. Pharmacol. Ther. 2008 28 : 431 42.
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 431-442
    • Lanza, F.L.1    Marathi, U.K.2    Arand, B.S.3    Lichtenbergers, L.M.4
  • 61
    • 33747608176 scopus 로고    scopus 로고
    • A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model
    • Dvir E, Friedman JE, Lee TY et al. A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p- chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3- phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model. J. Pharmacol. Exp. Ther. 2006 318 : 1248 56.
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 1248-1256
    • Dvir, E.1    Friedman, J.E.2    Lee, T.Y.3
  • 62
    • 0034971407 scopus 로고    scopus 로고
    • Phosphatidylcholine association increases the anti-inflammatory and analgesic activity of ibuprofen in acute and chronic rodent models of joint inflammation; Relationship to alterations in bioavailability and cyclooxygenase-inhibitory potency
    • Lichetenberger LM, Romero JJ, De Fuijter WMJ et al. Phosphatidylcholine association increases the anti-inflammatory and analgesic activity of ibuprofen in acute and chronic rodent models of joint inflammation; relationship to alterations in bioavailability and cyclooxygenase-inhibitory potency. J. Pharmacol. Exp. Ther. 2001 298 : 279 87.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 279-287
    • Lichetenberger, L.M.1    Romero, J.J.2    De Fuijter, W.M.J.3
  • 63
    • 48849113291 scopus 로고    scopus 로고
    • Membrane fusion: A new function of non steroidal anti-inflammatory drugs
    • Chakraborty H, Mondal S, Sarkar M. Membrane fusion: a new function of non steroidal anti-inflammatory drugs. Biophys. Chem. 2008 137 : 28 34.
    • (2008) Biophys. Chem. , vol.137 , pp. 28-34
    • Chakraborty, H.1    Mondal, S.2    Sarkar, M.3
  • 64
    • 4444347046 scopus 로고    scopus 로고
    • Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats
    • Santos LH, Feres CA, Melo FH et al. Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats. Braz. J. Med. Biol. Res. 2004 37 : 1205 13.
    • (2004) Braz. J. Med. Biol. Res. , vol.37 , pp. 1205-1213
    • Santos, L.H.1    Feres, C.A.2    Melo, F.H.3
  • 65
  • 66
    • 0038121687 scopus 로고    scopus 로고
    • Zinc-naproxen: Synthesis, physicochemical and biological evaluation
    • Sharma J, Singla AK, Dhawan S. Zinc-naproxen: synthesis, physicochemical and biological evaluation. Int. J. Pharm. 2003 260 : 217 27.
    • (2003) Int. J. Pharm. , vol.260 , pp. 217-227
    • Sharma, J.1    Singla, A.K.2    Dhawan, S.3
  • 67
    • 0031031097 scopus 로고    scopus 로고
    • NO-naproxen vs. naproxen: Ulcerogenic, analgesic and anti-inflammatory effects
    • Davies NM, Roseth AG, Appleyard CB et al. NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Aliment. Pharmacol. Ther. 1997 11 : 69 79.
    • (1997) Aliment. Pharmacol. Ther. , vol.11 , pp. 69-79
    • Davies, N.M.1    Roseth, A.G.2    Appleyard, C.B.3
  • 68
    • 0029100370 scopus 로고
    • Nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
    • Elliott SN, Mcknight W, Cirino G, Wallase JL. Nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology. 1995 109 : 524 30.
    • (1995) Gastroenterology. , vol.109 , pp. 524-530
    • Elliott, S.N.1    McKnight, W.2    Cirino, G.3    Wallase, J.L.4
  • 69
    • 33846466533 scopus 로고    scopus 로고
    • Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate
    • Jansson EA, Petersson J, Reinders C et al. Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate. Free. Rad. Biol. Med. 2007 42 : 510 8.
    • (2007) Free. Rad. Biol. Med. , vol.42 , pp. 510-518
    • Jansson, E.A.1    Petersson, J.2    Reinders, C.3
  • 70
    • 27144472247 scopus 로고    scopus 로고
    • Sidenafil offers protection against NSAID-induced gastric injury
    • Sawatzky DA, Megson IL, Rossi AG. Sidenafil offers protection against NSAID-induced gastric injury. Br. J. Pharmacol. 2005 146 : 477 8.
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 477-478
    • Sawatzky, D.A.1    Megson, I.L.2    Rossi, A.G.3
  • 71
    • 39749198508 scopus 로고    scopus 로고
    • The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage
    • Aydinli B, Yildirgan MI, Oztürk G et al. The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulus. Travma. Acil. Cerrahi. Derg. 2007 13 : 268 73.
    • (2007) Ulus. Travma. Acil. Cerrahi. Derg. , vol.13 , pp. 268-273
    • Aydinli, B.1    Yildirgan, M.I.2    Oztürk, G.3
  • 72
    • 0035584272 scopus 로고    scopus 로고
    • Dual inhibitors of cyclooxygenase and 5-lipoxygenase A new avenue in anti-inflammatory therapy?
    • Fiorucci S, Meli R, Bucci M, Cirino G. Dual inhibitors of cyclooxygenase and 5-lipoxygenase A new avenue in anti-inflammatory therapy? Biochem. Pharmacol. 2001 62 : 1433 8.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 1433-1438
    • Fiorucci, S.1    Meli, R.2    Bucci, M.3    Cirino, G.4
  • 73
    • 0035662474 scopus 로고    scopus 로고
    • Dual acting anti-inflammatory drugs; A reappraisal
    • Bertolini A, Sandrini M. Dual acting anti-inflammatory drugs; a reappraisal. Pharmacol. Res. 2001 44 : 437 50.
    • (2001) Pharmacol. Res. , vol.44 , pp. 437-450
    • Bertolini, A.1    Sandrini, M.2
  • 74
    • 0029816469 scopus 로고    scopus 로고
    • Effect of lipoxygenase inhibitors and leukotriene anatagonists on acute and chronic gastric hemorrhagic mucosal lesions in ulcer models in the rat
    • Gyomber E, Vattay P, Szabo S, Rainsford KD. Effect of lipoxygenase inhibitors and leukotriene anatagonists on acute and chronic gastric hemorrhagic mucosal lesions in ulcer models in the rat. J. Gastroenterol. Hepatol. 1996 11 : 922 7.
    • (1996) J. Gastroenterol. Hepatol. , vol.11 , pp. 922-927
    • Gyomber, E.1    Vattay, P.2    Szabo, S.3    Rainsford, K.D.4
  • 75
    • 25144469765 scopus 로고    scopus 로고
    • Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs
    • Ushijima H, Tanaka KI, Takeda M, Katsu T, Mima S, Mizushima T. Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. Mol. Pharmacol. 2005 68 : 1156 61.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1156-1161
    • Ushijima, H.1    Tanaka, K.I.2    Takeda, M.3    Katsu, T.4    Mima, S.5    Mizushima, T.6
  • 76
    • 34247258850 scopus 로고    scopus 로고
    • Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial-STORM STUDY
    • Park SH, Cho CS, Lee OH et al. Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: a randomized, multicenter, controlled trial-STORM STUDY. J. Clin. Biochem. Nutr. 2007 40 : 148 55.
    • (2007) J. Clin. Biochem. Nutr. , vol.40 , pp. 148-155
    • Park, S.H.1    Cho, C.S.2    Lee, O.H.3
  • 78
    • 0034530981 scopus 로고    scopus 로고
    • Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal anti-inflammatory drug-induced injury in arthritic rats
    • Okuyama K, Jinbo M, Saito N, Igarashi S, Narita H, Kinoshita H. Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal anti-inflammatory drug-induced injury in arthritic rats. Dig. Dis. Sci. 2000 45 : 2175 81.
    • (2000) Dig. Dis. Sci. , vol.45 , pp. 2175-2181
    • Okuyama, K.1    Jinbo, M.2    Saito, N.3    Igarashi, S.4    Narita, H.5    Kinoshita, H.6
  • 79
    • 33846959507 scopus 로고    scopus 로고
    • Zinc carosine, a health food supplement that stabilized small bowel integrity and stimulates gut repair processes
    • Mohmood A, FitzGerald AJ, Marchbank T et al. Zinc carosine, a health food supplement that stabilized small bowel integrity and stimulates gut repair processes. Gut 2007 56 : 168 75.
    • (2007) Gut , vol.56 , pp. 168-175
    • Mohmood, A.1    Fitzgerald, A.J.2    Marchbank, T.3
  • 81
    • 47749137367 scopus 로고    scopus 로고
    • Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells
    • Matsuu-Matsuyama M, Shichijo K, Okaichi K et al. Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells. J. Radiat. Res. 2008 49 : 341 7.
    • (2008) J. Radiat. Res. , vol.49 , pp. 341-347
    • Matsuu-Matsuyama, M.1    Shichijo, K.2    Okaichi, K.3
  • 82
    • 0036938045 scopus 로고    scopus 로고
    • Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils
    • Ishihara R, Iish H Sakain N et al. Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils. Helicobacter. 2002 7 : 384 9.
    • (2002) Helicobacter. , vol.7 , pp. 384-389
    • Ishihara, R.1    Iish, H.2    Sakain, N.3
  • 83
    • 0033776181 scopus 로고    scopus 로고
    • Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells
    • DOI 10.1254/jjp.84.63
    • Fuji Y, Matsura T, Kai M, Kawasaki H, Yamada K. Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells. Jpn. J. Pharmacol. 2000 84 : 63 70. (Pubitemid 30777261)
    • (2000) Japanese Journal of Pharmacology , vol.84 , Issue.1 , pp. 63-70
    • Fujii, Y.1    Matsura, T.2    Kai, M.3    Kawasaki, H.4    Yamada, K.5
  • 84
    • 33846959507 scopus 로고    scopus 로고
    • Zinc carnosine, a health food supplement that stabilizes small bowel integrity and stimulates gut repair processes
    • Mahmood A, FitzGerald AJ, Marchbank T et al. Zinc carnosine, a health food supplement that stabilizes small bowel integrity and stimulates gut repair processes. Gut. 2007 56 : 168 75.
    • (2007) Gut. , vol.56 , pp. 168-175
    • Mahmood, A.1    Fitzgerald, A.J.2    Marchbank, T.3
  • 85
    • 57049135650 scopus 로고    scopus 로고
    • Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis
    • Sugino H, Kumagai N, Watanabe S et al. Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis. J. Gastroenterol. Hepatol. 2008 23 : 1909 16.
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , pp. 1909-1916
    • Sugino, H.1    Kumagai, N.2    Watanabe, S.3
  • 87
    • 0034219226 scopus 로고    scopus 로고
    • Applicability of zinc complex of L-carnosine for medical use
    • Matsukura T, Tanaka H. Applicability of zinc complex of L-carnosine for medical use. Biochemistry 2000 65 : 961 8.
    • (2000) Biochemistry , vol.65 , pp. 961-968
    • Matsukura, T.1    Tanaka, H.2
  • 88
    • 0032825029 scopus 로고    scopus 로고
    • Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells
    • Shimada T, Watanabe N, Ohtsuka Y et al. Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells. J. Pharmacol. Exp. Ther. 1999 291 : 345 52.
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 345-352
    • Shimada, T.1    Watanabe, N.2    Ohtsuka, Y.3
  • 89
    • 7844227321 scopus 로고    scopus 로고
    • Insulin-like growth factor i plays a role in gastric wound healing: Evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair model
    • Watanabe S, Wang XE, Hirose M et al. Insulin-like growth factor I plays a role in gastric wound healing: evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair model. Aliment. Pharmacol. Ther. 1998 12 : 1131 8.
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 1131-1138
    • Watanabe, S.1    Wang, X.E.2    Hirose, M.3
  • 92
    • 0025147458 scopus 로고
    • Effects of zinc acexamate on gastric lesions induced by aspirin: A morphological study
    • Bravo L, Escolar G, Navarro C, Fontarnau R, Bulbena O. Effects of zinc acexamate on gastric lesions induced by aspirin: a morphological study. Eur. J. Pharmacol. 1990 190 : 59 65.
    • (1990) Eur. J. Pharmacol. , vol.190 , pp. 59-65
    • Bravo, L.1    Escolar, G.2    Navarro, C.3    Fontarnau, R.4    Bulbena, O.5
  • 93
    • 0028304268 scopus 로고
    • Gastrotoxic activity and inhibitory effects on gastric mucosal PGE2 production with different non-steroidal anti-inflammatory drugs: Modifications induced by pretreatment with zinc acexamate
    • Navarro C, Bravo ML, Carulla C, Bulbena O. Gastrotoxic activity and inhibitory effects on gastric mucosal PGE2 production with different non-steroidal anti-inflammatory drugs: modifications induced by pretreatment with zinc acexamate. Prostaglandins Leukot. Essent. Fatty Acids 1994 50 : 305 10.
    • (1994) Prostaglandins Leukot. Essent. Fatty Acids , vol.50 , pp. 305-310
    • Navarro, C.1    Bravo, M.L.2    Carulla, C.3    Bulbena, O.4
  • 94
    • 0032982677 scopus 로고    scopus 로고
    • Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa
    • Tsutsui Y, Nakamura Y, Yamaguchi S, Kawanaka N, Sato M. Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa. Pharmacology. 1999 58 : 209 19.
    • (1999) Pharmacology. , vol.58 , pp. 209-219
    • Tsutsui, Y.1    Nakamura, Y.2    Yamaguchi, S.3    Kawanaka, N.4    Sato, M.5
  • 95
    • 0028278348 scopus 로고
    • Multicenter clinical trial of zinc acexamate in the prevention of nonsteroidal anti-inflammatory drug induced gastroenteropathy. Spanish Study Group on NSAID Induced Gastroenteropathy Prevention
    • Rodríguez de la Serna A, Díaz-Rubio M. Multicenter clinical trial of zinc acexamate in the prevention of nonsteroidal anti-inflammatory drug induced gastroenteropathy. Spanish Study Group on NSAID Induced Gastroenteropathy Prevention. J. Rheumatol. 1994 21 : 927 33.
    • (1994) J. Rheumatol. , vol.21 , pp. 927-933
    • Rodríguez De La Serna, A.1    Díaz-Rubio, M.2
  • 96
    • 18844448932 scopus 로고    scopus 로고
    • Lipoxin agonists: Turn right! to path of resolving neutrophil
    • Devchand PR. Lipoxin agonists: turn right! To path of resolving neutrophil. Mem. Inst. Oswaldo Cruz. 2005 100 : 55 7.
    • (2005) Mem. Inst. Oswaldo Cruz. , vol.100 , pp. 55-57
    • Devchand, P.R.1
  • 97
    • 47049091866 scopus 로고    scopus 로고
    • NO-donating NSAIDs and cancer: An overview with a note on whether NO -s required for their action
    • Rigas B, Williams JL. NO-donating NSAIDs and cancer: an overview with a note on whether NO -s required for their action. Nitric Oxide 2008 19 : 199 204.
    • (2008) Nitric Oxide , vol.19 , pp. 199-204
    • Rigas, B.1    Williams, J.L.2


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