Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress: A randomized controlled trial

American Journal of Gastroenterology

Volumn 98, Issue 2, 2003, Pages 348-353

  Aghdassi, Elaheh ^b   Wendland, Barbara E ^b   Steinhart, A Hillary ^b   Wolman, Stephen L ^b   Jeejeebhoy, Khursheed ^b   Allard, Johane P ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; CRYPTOXANTHIN; ETHANE; IMMUNOSUPPRESSIVE AGENT; ISOPROSTANE; LIPID PEROXIDE; LYCOPENE; MESALAZINE; OROSOMUCOID; PENTANE; RETINOL; STEROID; TOCOPHEROL; VITAMIN; XANTHOPHYLL; ZINC;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DIET SUPPLEMENTATION; DISEASE ACTIVITY; HUMAN; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; NUTRITIONAL REQUIREMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN SUPPLEMENTATION;

EID: 0037282962     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(02)05894-X     Document Type: Article

References (48)

1. Grisham MB. Oxidants and free radicals in inflammatory bowel disease. Lancet 1994;344:859-61.
2. Grisham MB, Granger DN. Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988;33:6S-15S.
3. Harris ML, Schiller HJ, Reilly PM, et al. Free radicals and other reactive oxygen metabolites in inflammatory bowel disease. Cause, consequence, or epiphenoma? Pharmacol Ther 1992;53:375-408.
4. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-76.
5. Slater TF. Free radical mechanisms in tissue injury. Biochem J 1984;222:1-15.
6. Halliwell B, Chirico S. Lipid peroxidation: Its mechanism, measurement, and significance. Am J Clin Nutr 1993;57(suppl 5):715-24.
7. Halliwell B. Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence? Lancet 1994;344:721-4.
8. Verspaget HW, Pena AS, Weterman IT, et al. Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content. Gut 1988;29:223-8.
9. Simmonds NJ, Allen RE, Stevens TRJ, et al. Chemiluminescence assay of reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology 1992;103:186-96.
10. Kokoszka J, Nelson RL. Determination of inflammatory bowel disease activity by breath pentane analysis. Dis Colon Rectum 1993;36:597-601.
11. McKenzie SJ, Baker MS, Buffington GD, et al. Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J Clin Invest 1996;98:136-41.
12. Miralles-Barrachina O, Savoye G, Belmonte-Zalar L, et al. Low levels of glutathione in endoscopic biopsies of patients with Crohn's colitis: The role of malnutrition. Clin Nutr 1999;18:313-7.
13. Buffington GD, Doe WF. Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients. Free Rad Res 1995;22:131-43.
14. D'Odorico A, Pozzato F, Minotto M, et al. Plasma carotenoids and other antioxidant levels in Crohn's disease. Gastroenterology 1996;110:A897 (abstract).
15. Geerling BJ, Badart-Smook A, Stockbrugger RW, et al. Comprehensive nutritional status in patients with long-standing Crohn's disease currently in remission. Am J Clin Nutr 1998;67:919-26.
16. Wendland B, Aghdassi E, Tam C, et al. Lipid peroxidation and plasma antioxidant micronutrients in Crohn's disease. Am J Clin Nutr 2001;74:259-64.
17. Allard JP, Aghdassi E, Chau J, et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV infected subjects. AIDS 1998;12:1653-9.
18. Niki E, Noguchi N, Tsuchihashi H, et al. Interaction among vitamin C, vitamin E, and beta-carotene. Am J Clin Nutr 1995;62(suppl 6):1322S-1326S.
19. Allard JP, Aghdassi E, Chau J, et al. Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection. Am J Clin Nutr 1998;67:143-7.
20. Allard JP, Royall D, Kurian R, et al. Effects of beta-carotene supplementation on lipid peroxidation in humans. Am J Clin Nutr 1994;59:884-90.
21. Lemoyne M, Van Gossum A, Kurian R, et al. Breath pentane analysis as an index of lipid peroxidation: A functional test of vitamin E status. Am J Clin Nutr 1987;46:267-72.
22. Morrow JD, Hill KE, Burk RF, et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 1990;87:9383-7.
23. Sapuntzakis MS, Bowen PE, Kikendall JW, et al. Simultaneous determination of serum retinol and various carotenoids: Their distribution in middle-aged men and women. J Micronutr Anal 1987;3:27-45.
24. Nata C, Stacewicz-Sapuntzakis M, Bhagavan H, et al. Low serum levels of carotenoids in sickle cell anemia. Eur J Hematol 1988;41:131-5.
25. Bessey OA, Lowry OH, Brock MJ. The quantitative determination of ascorbic acid in small amounts of white blood cells and platelets. J Biol Chem 1947;168:197-204.
26. Best WR, Becktel JM, Singleton JW. Development of Crohn's disease activity index. Gastroenterology 1976;70:439-44.
27. Best WR, Becktel JM, Singleton JW. Rederived values of the eight coefficients of the Crohn's disease activity index (CDAI). Gastroenterology 1979;77:843-6.
28. Summers RW, Switz DM, Sessions JT Jr, et al. National Co-operative Crohn's Disease Study. Results of drug treatment. Gastroenterology 1979;77:847-69.
29. Hodgson HJF. Laboratory markers in inflammatory bowel disease. In: Allen RN, Rhodes JM, Hanauer SB, medical eds.; Keighley MRB, Alexander-Williams J, Fazio VWI, surgical eds. Inflammatory bowel disease, 3rd ed. New York: Churchill Livingstone, 1997:329.
30. Fernandez-Banares F, Abad-Lacruz A, Xiol X, et al. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 1989;84:744-88.
31. Hoffenberg EJ, Deutsch J, Smith S, et al. Circulating antioxidant concentrations in children with inflammatory bowel disease. Am J Clin Nutr 1997;65:1482-8.
32. Kirk AP, Cason J, Fordham JN, et al. Polymorphonuclear leukocyte function in ulcerative colitis and Crohn's disease. Dig Dis Sci 1983;28:236-48.
33. Kitahora T, Suzuki K, Asakura H, et al. Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease. Dig Dis Sci 1988;33:951-5.
34. Wade CR, Van Rij AM. In vivo lipid peroxidation in man as measured by the respiratory excretion of ethane, pentane, and other low-molecular weight hydrocarbons. Anal Biochem 1985;150:1-7.
35. Dumelin EE, Tappel AL. Hydrocarbon gases produced during in vitro peroxidation of polyunsaturated fatty acids and decomposition of pre-formed hydroperoxides. Lipids 1977;12:894-900.
36. Filser JG, Bolt HM, Muliawan H, et al. Qualitative evaluation of ethane and n-pentane as indicators of lipid peroxidation in vivo. Arch Toxicol 1983;52:135-47.
37. Hoshino E, Shariff R, Van Gossum A, et al. Vitamin E suppresses increased lipid peroxidation in cigarette smokers. J PEN 1990;14:300-5.
38. Kivits G, Ganguli-Swarttouw MA, Christ EJ. The composition of alkanes exhaled air of rats as a result of lipid peroxidation in vivo: Effects of dietary fatty acids, vitamin E and selenium. Biochim Biophys Acta 1981;665:559-70.
39. Hartmut F, Hintze T, Bimboes S, et al. Monitoring lipid peroxidation by breath analysis: Endogenous hydrocarbons and their metabolic elimination. Toxicol Appl Pharmacol 1980;56:337-44.
40. Litov RE, Gee DL, Downey JE, et al. The role of lipid peroxidation during chronic and acute exposure to ethanol as determined by pentane expiration in the rat. Lipids 1981;16:52-7.
41. Pryor WA, Stone K. Oxidants in cigarette smoke. Ann N Y Acad Sci 1993;686:12-27.
42. Van Antwerpen L, Theron AJ, Myer MS, et al. Cigarette smoke-mediated oxidant stress, phagocytes, vitamin C, vitamin E and tissue injury. Ann N Y Acad Sci 1993;686:53-65.
43. Morrow JD, Minton TA, Mukundan CR, et al. Free radical-induced generation of isoprostanes in vivo. J Biol Chem 1994;269:4317-26.
44. Morrow JD, Roberts IILJ. The isoprostanes: Current knowledge and directions for future research. Biochem Pharmacol 1996;51:1-9.
45. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, E, selenium, and carotenoids. Washington, D.C.: National Academy Press, 2000.
46. Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish oil preparation on relapses in Crohn's disease. N Engl J Med 1996;334:1557-60.
47. Calkins BM. A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989;34:1841-54.
48. Breuer-Katschinski BD, Hollander N, Goebell H. Effect of cigarette smoking on the course of Crohn's disease. Eur J Gastroenterol 1996;8:225-8.