Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis

Journal of Nutrition

Volumn 132, Issue 10, 2002, Pages 3146-3150

  Carrier, Julie ^a   Aghdassi, Elaheh ^a   Cullen, Jim ^b   Allard, Johane P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

Colitis; Dextran sulfate sodium; Iron; Oxidative stress; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; DEXTRAN SULFATE; GLUTATHIONE PEROXIDASE; IRON; ISOPROSTANE; LIPID PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLITIS; CONTROLLED STUDY; DISEASE ACTIVITY; ENTERITIS; INFLAMMATION; IRON DEFICIENCY ANEMIA; IRON THERAPY; MALE; MUCOSA INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; RAT; RECTUM HEMORRHAGE; SCORING SYSTEM;

ANIMALIA;

EID: 0036790056     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.10.3146     Document Type: Article

References (48)

1. Richter, J. R. (1987) Management of inflammatory bowel disease. In: Primary Care (Goroll, A. H. eds.), pp. 329-336. JB Lippincott, Philadelphia, PA.
2. Harris, M. L., Shiller, H. J., Reilly, P. M., Donowitz, M., Grisham, M. B. & Bulkley, G. B. (1992) Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomena? Pharmaceutic. Ther. 53: 375-408.
3. Klebanoff, S. J. (1992) Oxygen metabolites from phagocytes. In: Gall, J. I., Goldstein, I. M., Snyderman, R., eds., pp. 541-588. Raven Press, New York, NY.
4. McKenzie, S. J., Baker, M. S., Buffinton, G. D. & Doe, W. F. (1996) Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J. Clin. Invest. 98: 136-141.
5. Grisham, M. B. & Granger, D. N. (1988) Neutrophil-mediated mucosal injury. Dig. Dis, Sci. 33: 6S-15S.
6. Aust, S. D. & Svingen, B. A. (1982) The role of iron in enzymatic lipid peroxidation. In: Free Radicals in Biology (Pryor, W. A., ed.), vol. V., pp. 1-28, Academic Press, New York, NY.
7. Baeuerle, P. A. & Henkle, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12: 141-179.
8. Fernandez-Banares, F., Abad-Lacruz, A., Xiol, X., Gine, J. J., Dolz, C., Cabre, E., Esteve, M., Gonzalez-Huix, F. & Gassull, M.A. (1989) Vitamin status in patients with inflammatory bowel disease. Am. J. Gastroenterol. 85: 744-748.
9. Bousvaros, A., Zurakowski, D., Duggan, C., Law, T., Rifai, N., Goldberg, N. E. & Leichtner, A. M. (1998) Vitamins A and E serum levels in children and young adults with inflammatory bowel disease: effect of disease activity. J. Pediatr. Gastroenterol. Nutr. 26: 129-135.
10. Buffinton, G. D. & Doe, W. F. (1995) Depleted mucosal antioxidant defenses in inflammatory bowel disease. Free Radic. Biol. Med. 19: 911-918.
11. Erichsen, K., Hausken, T. & Berge, R. (1998) Effect of oral iron therapy on antioxidant defense in active Crohn's disease. Digestion. 59: 134 (abs.).
12. Aghdassi, E., Carrier, J., Cullen, J., Tishler, M. & Allard, J. P.; 2001. The effect of iron supplementation on oxidative stress and intestinal inflammation in rats with acute colitis. Dig. Dis. Sci. 46: 1088-1094.
13. Burton, G. W. & Ingold, K. U. (1986) Vitamin E: application of the principles of physical organic chemistry to the exploration of structure and function. Acc. Chem. Res. 19: 194-201.
14. Burton, G. W., Joyce, A. & Ingold, K. U. (1983) Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch. Biochem. Biophys. 221: 281-290.
15. Suzuki, Y. J. & Packer, L. (1993) Inhibition of NF-κB activation by vitamin E derivatives. Biochem. Biophys. Res. Commun. 193: 277-283.
16. Suzuki, Y. J. & Packer, L. (1993) Inhibition of NF-κB DNA binding activity by α-tocopheryl succinate. Biochem. Mol. Biol. Int. 31: 693-700.
17. Elson, C. O., Sartor, R. B., Tennyson, G. S. & Riddell, R. H. (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109: 1344-1367.
18. Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y. & Nakaya, R. (1990) A novel method I the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702.
19. Schwartz, S., Dahl, J., Ellefson, M. & Ahlquist, D. (1983) The Hemoquant test: a specific and quantitative determination of heme (hemoglobin) in feces and other materials. Clin. Chem. 29: 2061-2067.
20. Coles, E. F. & Starnes, E. (1991) Use of HemoQuant assays to assess the effect of oral iron preparations on stool hemoccult tests. Am. J. Gastroenterol. 86: 1442-1444.
21. Murthy, S. N., Cooper, H. S., Shim, H., Shah, R., Ibrahim, S. & Sedergran, D. (1993) Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporine. Dig. Dis. Sci. 38: 1722-1734.
22. Onderdonk, A. B. & Bartlett, J. G. (1979) The role of bacteria in experimental ulcerative colitis. Am. J. Clin. Nutr. 32: 258-265.
23. Grant, G. H. & Kachnar, J. F. (1976) The proteins of body fluids. In: Fundamentals of Clinical Chemistry (Tritz, N. W., ed.), pp. 298-376. Saunders, Philadelphia, PA.
24. Sapuntzakis, M. S., Bowen, P. E., Kikendall, J. W. & Berges, B. (1987) Simultaneous determination of serum retinol and various carotenoids: their distribution in middle-aged men and women. J. Micronutr. Anal. 3: 27-45.
25. Babbs, C. F. (1992) Oxygen radicals in ulcerative colitis. Free Radic. Biol. Med. 13: 169-181.
26. Crosby, W. H. (1977) Who needs iron? N. Engl. J. Med. 297: 543-546.
27. American Medical Association. (1980) AMA Drug Evaluations. 4th edn. p. 1055.
28. Babbs, C. F. (1990) Free radicals and the etiology of colon cancer. Free Radic. Biol. Med. 8: 191-200.
29. Lundl, E. K., Wharf, S. G., Fairweather-Tait, S. J. & Johnson, I. T. (1999) Oral ferrous sulfate supplements increase the free radical -generating capacity of feces from healthy volunteers. Am. J. Clin. Nutr. 69: 250-255.
30. Soyars, K. E. & Fischer, J. G. (1998) Iron supplementation does not affect cell proliferation of aberrant crypt foci development in the colon of Sprague-Dawley rats. J. Nutr. 128: 764-770.
31. Millar, A. D., Rampton, D. S. & Blake, D. R. (2000) Effects of iron and iron chelation in vitro on mucosal oxidant activity in ulcerative colitis. Aliment. Pharmacol. Ther. 14: 1163-1168.
32. Reifen, R., Matas, Z., Zeidel, L., Berkovitch, Z. & Bujanover, Y. (2000) Iron supplementation may aggravate inflammatory status of colitis in a rat model. Dig. Dis. Sci. 45: 394-397.
33. Oldenburg, B., Van Berge Henegouwen, G. P., Rennick, D., Van Asbeck, B. S. & Koningsberger, J. C. (2000) Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice. Eur. J. Clin. Invest. 30: 505-510.
34. Axelsson, L. G., Landstrom, E. & Bylund-Fellenius, A. C. (1998) Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulfasalazine and olsalazine. Aliment. Pharmacol. Ther. 12: 925-934.
35. Imlay, J. A., Chin, S. M. & Linn, S. (1988) Toxic damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240: 640-642.
36. Caughey, W. S. & Watdins, J. A. (1985) Oxyradical and peroxide formation by hemoglobin and myoglobin. In: Handbook of Methods for Oxygen Radical Research (Greenwald, R. A., ed.), pp. 95-104. CRC Press, Boca Raton, FL.
37. Bucher, J. R., Tien, M. & Aust, S. D. (1983) The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron. Biochem. Biophys. Res. Commun. 111: 777-784.
38. Madesh, M., Ibrahim, S. A. & Balasubramanian, K. A. (1997) Phospholipase D activity in the intestinal mitochondria: activation by oxygen free radicals. Free Radic. Biol. Med. 23: 271-277.
39. Carini, R., Parola, M., Dianzani, M. U. & Albano, E. (1992) Mitochondrial damage and its role in causing hepatocyte injury and stimulation of lipid peroxidation by iron nitriloacetate. Arch. Biochem. Biophys. 297: 110-118.
40. Cuzzocrea, S., Mazzon, E., De Sarro & Caputi, A. P. (2000) Role of free radicals and poly (ADP-ribose) synthethase in intestinal tight junction permeability. Mol. Med. 6: 766-778.
41. Robinson, C. E., Kottapalli, V., D'Astice, M., fields, J. Z., Winstrip, D. & Keshavarzian, A. (1997) Regulation of neutrophils in ulcerative colitis by colonic factors: a possible mechanism of neutrophil activation and tissue damage. J. Lab. Clin. Med. 130: 590-606.
42. Lin, M., Rippe, R. A., Niemela, O., Brittenhan, G. & Tsukamoto,A. (1990) Role of iron in NF-κB activation and cytokine gene expression by rat hepatic macrophages. Am. J. Physiol. 272: G1355-G1364.
43. Schmidt, K. N., Amstad, P., Cerutti, B. & Baeuerle, P. A. (1995) The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB. Chem. Biol. 2: 13-22.
44. Sato, K., Kanazawa, A., Ota, N., Nakamura, T. & Fujimoto, K. (1998) Dietary supplementation of catechins and α-tocopherol accelerate healing of trinitrobenzene sulfonic acid-induced ulcerative colitis. J. Nutr. Sci. Vitaminol. (Tokyo) 44: 769-778.
45. MacMahon, M. T. & Neale, G. (1970) The absorption of α-tocopherol in control subjects and in patients with intestinal malabsorption. Clin. Sci. 38: 197-210.
46. Kelleher, J., Davies, T. & Losowsky, M. S. (1969) Absorption and tissue uptake of α-tocopherol in the rat. Biochem. J. 114: 74P.
47. Schreiber, S., Nikolaus, S. & Hape, J. (1998) Activation of nuclear factor κB in inflammatory bowel disease. Gut 42: 477-484.
48. Rogler, G., Brand, K., Vogl, D., Page, S., Hofmeister, R., Andus, T., Knuechel, R., Baeuerle, P. A., Scholmerich, J. & Gross, V. (1998) Nuclear factor kappa B is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 115: 357-369.