Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury

Journal of Gastroenterology

Volumn 45, Issue 7, 2010, Pages 692-702

  Omatsu, Tatsushi ^a   Naito, Yuji ^a   Handa, Osamu ^a   Mizushima, Katsura ^a   Hayashi, Natsuko ^a   Qin, Ying ^a   Harusato, Akihito ^a   Hirata, Ikuhiro ^a   Kishimoto, Etsuko ^a   Okada, Hitomi ^a   Uchiyama, Kazuhiko ^a   Ishikawa, Takeshi ^a   Takagi, Tomohisa ^a   Yagi, Nobuaki ^a   Kokura, Satoshi ^a   Ichikawa, Hiroshi ^b   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

Author keywords

Apoptosis; NSAIDs; Protein S oxidation; Reactive oxygen species; Zinc

Indexed keywords

CARNOSINE; CASPASE 3; CYTOCHROME C; FLUORESCENT DYE; HOE 33342; INDOMETACIN; POLAPREZINC; PROPIDIUM IODIDE; PROTEIN S; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; ZINC SULFATE; ANTIULCER AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANOMETALLIC COMPOUND; ZINC DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; INHIBITION KINETICS; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; DRUG EFFECTS; EPITHELIUM CELL; INTESTINE MUCOSA; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TOXICITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; APOPTOSIS; CARNOSINE; CELL LINE; EPITHELIAL CELLS; INDOMETHACIN; INTESTINAL MUCOSA; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN S; RATS; REACTIVE OXYGEN SPECIES; ZINC COMPOUNDS;

EID: 77955660458     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0213-9     Document Type: Article

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