메뉴 건너뛰기




Volumn 233, Issue 4, 2016, Pages 615-624

The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice

Author keywords

Feeding; Locomotor activity; Motivation; Operant; SB242084; Serotonin receptor

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; SEROTONIN 2C RECEPTOR; 6-CHLORO-5-METHYL-1-((2-(2-METHYLPYRID-3-YLOXY)PYRID-5-YL)CARBAMOYL)INDOLINE; AMINOPYRIDINE DERIVATIVE; INDOLE DERIVATIVE; SEROTONIN 2 ANTAGONIST;

EID: 84955457579     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-4135-3     Document Type: Article
Times cited : (33)

References (50)
  • 1
    • 0031770953 scopus 로고    scopus 로고
    • Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance
    • Aberman JE, Ward SJ, Salamone JD (1998) Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance. Pharmacol Biochem Behav 61:341-348. doi: 10.1016/S0091-3057(98)00112-9
    • (1998) Pharmacol Biochem Behav , vol.61 , pp. 341-348
    • Aberman, J.E.1    Ward, S.J.2    Salamone, J.D.3
  • 2
    • 33846426067 scopus 로고    scopus 로고
    • Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
    • Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113(2):296-320. doi: 10.1016/j.pharmthera.2006.08.004
    • (2007) Pharmacol Ther , vol.113 , Issue.2 , pp. 296-320
    • Alex, K.D.1    Pehek, E.A.2
  • 3
    • 84930397912 scopus 로고    scopus 로고
    • A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task
    • Bailey MR, Jensen G, Taylor K, Mezias C, Williamson C, Silver R, Simpson EH, Balsam PD (2015) A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task. Behav Neurosci 129:269-280. doi: 10.1037/bne0000060
    • (2015) Behav Neurosci , vol.129 , pp. 269-280
    • Bailey, M.R.1    Jensen, G.2    Taylor, K.3    Mezias, C.4    Williamson, C.5    Silver, R.6    Simpson, E.H.7    Balsam, P.D.8
  • 4
    • 77955979601 scopus 로고    scopus 로고
    • Goal representations and motivational drive in schizophrenia: The role of prefrontal-striatal interactions
    • Barch DM, Dowd EC (2010) Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions. Schizophr Bull 36:919-934. doi: 10.1093/schbul/sbq068
    • (2010) Schizophr Bull , vol.36 , pp. 919-934
    • Barch, D.M.1    Dowd, E.C.2
  • 6
    • 84922454757 scopus 로고    scopus 로고
    • Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule
    • Bezzina G, Body S, Cheung THC, Hampson CL, Bradshaw CM, Glennon JC, Szabadi E (2015) Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule. Psychopharmacology 232:699-711. doi: 10.1007/s00213-014-3700-5
    • (2015) Psychopharmacology , vol.232 , pp. 699-711
    • Bezzina, G.1    Body, S.2    Cheung, T.H.C.3    Hampson, C.L.4    Bradshaw, C.M.5    Glennon, J.C.6    Szabadi, E.7
  • 7
    • 79751533753 scopus 로고    scopus 로고
    • Apathy in neuropsychiatric disease: Diagnosis, pathophysiology, and treatment
    • Chase T (2011) Apathy in neuropsychiatric disease: diagnosis, pathophysiology, and treatment. Neurotox Res 19:266-278. doi: 10.1007/s12640-010-9196-9
    • (2011) Neurotox Res , vol.19 , pp. 266-278
    • Chase, T.1
  • 8
    • 0033778106 scopus 로고    scopus 로고
    • Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat
    • Clifton PG, Lee MD, Dourish CT (2000) Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat. Psychopharmacology 152:256-267. doi: 10.1007/s002130000504
    • (2000) Psychopharmacology , vol.152 , pp. 256-267
    • Clifton, P.G.1    Lee, M.D.2    Dourish, C.T.3
  • 9
    • 73949093633 scopus 로고    scopus 로고
    • Emotional experience in patients with schizophrenia revisited: Meta-analysis of laboratory studies
    • Cohen AS, Minor KS (2010) Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull 36:143-150. doi: 10.1093/schbul/sbn061
    • (2010) Schizophr Bull , vol.36 , pp. 143-150
    • Cohen, A.S.1    Minor, K.S.2
  • 10
    • 80955177188 scopus 로고    scopus 로고
    • Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. Sucrose-associated cues
    • Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S (2011) Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues. Neuropharmacology 61:513-523. doi: 10.1016/j.neuropharm.2011.04.034
    • (2011) Neuropharmacology , vol.61 , pp. 513-523
    • Cunningham, K.A.1    Fox, R.G.2    Anastasio, N.C.3    Bubar, M.J.4    Stutz, S.J.5    Moeller, F.G.6    Gilbertson, S.R.7    Rosenzweig-Lipson, S.8
  • 11
    • 33344469812 scopus 로고    scopus 로고
    • Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse
    • Dalton GL, Lee MD, Kennett GA, Dourish CT, Clifton PG (2006) Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacology 185:45-57. doi: 10.1007/s00213-005-0212-3
    • (2006) Psychopharmacology , vol.185 , pp. 45-57
    • Dalton, G.L.1    Lee, M.D.2    Kennett, G.A.3    Dourish, C.T.4    Clifton, P.G.5
  • 12
    • 1842610940 scopus 로고    scopus 로고
    • Constitutive activity of the Serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens
    • De Deurwaerdère P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the Serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241. doi: 10.1523/jneurosci.0112-04.2004
    • (2004) J Neurosci , vol.24 , pp. 3235-3241
    • De Deurwaerdère, P.1    Navailles, S.2    Berg, K.A.3    Clarke, W.P.4    Spampinato, U.5
  • 13
    • 0033990419 scopus 로고    scopus 로고
    • Preferential modulation of mesolimbic vs. Nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: A combined in vivo electrophysiological and microdialysis study
    • Di Giovanni G, Di Matteo V, Di Mascio M, Esposito E (2000) Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse 35:53-61. doi: 10.1002/(sici)1098-2396(200001)35:1<53::aid-syn7>3.0.co;2-2
    • (2000) Synapse , vol.35 , pp. 53-61
    • Di Giovanni, G.1    Di Matteo, V.2    Di Mascio, M.3    Esposito, E.4
  • 14
    • 0035961169 scopus 로고    scopus 로고
    • M-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors
    • Di Giovanni G, Di Matteo V, La Grutta V, Esposito E (2001) m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors. Neuroscience 103:111-116. doi: 10.1016/S0306-4522(00)00561-3
    • (2001) Neuroscience , vol.103 , pp. 111-116
    • Di Giovanni, G.1    Di Matteo, V.2    La Grutta, V.3    Esposito, E.4
  • 15
    • 0032588764 scopus 로고    scopus 로고
    • SB 242 084, a selective serotonin(2C) receptor antagonist, increases dopaminergic transmission in the mesolimbic system
    • Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (1999) SB 242 084, a selective serotonin(2C) receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 38:1195-1205. doi: 10.1016/s0028-3908(99)00047-7
    • (1999) Neuropharmacology , vol.38 , pp. 1195-1205
    • Di Matteo, V.1    Di Giovanni, G.2    Di Mascio, M.3    Esposito, E.4
  • 16
    • 0034685842 scopus 로고    scopus 로고
    • Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors
    • 10814735
    • Di Matteo M, Di Giovanni G, Di Mascio M, Esposito E (2000) Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain Res 865:85-90
    • (2000) Brain Res , vol.865 , pp. 85-90
    • Di Matteo, M.1    Di Giovanni, G.2    Di Mascio, M.3    Esposito, E.4
  • 19
    • 60849097854 scopus 로고    scopus 로고
    • Apathy is associated with executive functioning in first episode psychosis
    • Faerden A (2009) Apathy is associated with executive functioning in first episode psychosis. BMC Psychiatr 9:1. doi: 10.1186/1471-244x-9-1
    • (2009) BMC Psychiatr , vol.9 , pp. 1
    • Faerden, A.1
  • 20
    • 0038507697 scopus 로고    scopus 로고
    • Apathy and cognitive performance in older adults with depression
    • Feil D, Razani J, Boone K, Lesser I (2003) Apathy and cognitive performance in older adults with depression. Int J Geriatric Psychiatr 18:479-485. doi: 10.1002/gps.869
    • (2003) Int J Geriatric Psychiatr , vol.18 , pp. 479-485
    • Feil, D.1    Razani, J.2    Boone, K.3    Lesser, I.4
  • 21
    • 84895226931 scopus 로고    scopus 로고
    • Serotonin and reward-related behavior: Focus on 5-HT2C receptors
    • Di Giovanni G, Esposito E, Di Matteo V (eds) Humana Press
    • Fletcher P, Higgins G (2011) Serotonin and reward-related behavior: focus on 5-HT2C receptors. In: Di Giovanni G, Esposito E, Di Matteo V (eds) 5-HT2C receptors in the pathophysiology of CNS disease. Humana Press, Vol. 22, p 293-324
    • (2011) 5-HT2C Receptors in the Pathophysiology of CNS Disease , vol.22 , pp. 293-324
    • Fletcher, P.1    Higgins, G.2
  • 22
    • 67650680328 scopus 로고    scopus 로고
    • Characterizing the effects of 5-HT2C receptor ligands on motor activity and feeding behaviour in 5-HT2C receptor knockout mice
    • Fletcher PJ, Tampakeras M, Sinyard J, Slassi A, Isaac M, Higgins GA (2009) Characterizing the effects of 5-HT2C receptor ligands on motor activity and feeding behaviour in 5-HT2C receptor knockout mice. Neuropharmacology 57:259-267. doi: 10.1016/j.neuropharm.2009.05.011
    • (2009) Neuropharmacology , vol.57 , pp. 259-267
    • Fletcher, P.J.1    Tampakeras, M.2    Sinyard, J.3    Slassi, A.4    Isaac, M.5    Higgins, G.A.6
  • 23
    • 77957752613 scopus 로고    scopus 로고
    • Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement
    • Fletcher PJ, Sinyard J, Higgins GA (2010) Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav 97:170-178. doi: 10.1016/j.pbb.2010.07.002
    • (2010) Pharmacol Biochem Behav , vol.97 , pp. 170-178
    • Fletcher, P.J.1    Sinyard, J.2    Higgins, G.A.3
  • 24
    • 0033680203 scopus 로고    scopus 로고
    • Studies to investigate the role of 5-HT2C receptors on cocaine- and food-maintained behavior
    • 1:CAS:528:DC%2BD3cXosVKisb0%3D 11082456
    • Grottick AJ, Fletcher PJ, Higgins GA (2000) Studies to investigate the role of 5-HT2C receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther 295:1183-1191
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1183-1191
    • Grottick, A.J.1    Fletcher, P.J.2    Higgins, G.A.3
  • 25
    • 0036125176 scopus 로고    scopus 로고
    • Serotonin 2C receptor agonists and the behavioural satiety sequence in mice
    • Hewitt KN, Lee MD, Dourish CT, Clifton PG (2002) Serotonin 2C receptor agonists and the behavioural satiety sequence in mice. Pharmacol Biochem Behav 71:691-700. doi: 10.1016/S0091-3057(01)00709-2
    • (2002) Pharmacol Biochem Behav , vol.71 , pp. 691-700
    • Hewitt, K.N.1    Lee, M.D.2    Dourish, C.T.3    Clifton, P.G.4
  • 27
    • 0001099655 scopus 로고
    • Progressive ratio as a measure of reward strength
    • Hodos W (1961) Progressive ratio as a measure of reward strength. Science 134:943-944. doi: 10.1126/science.134.3483.943
    • (1961) Science , vol.134 , pp. 943-944
    • Hodos, W.1
  • 28
    • 0041706378 scopus 로고    scopus 로고
    • Apathy in schizophrenia: Clinical correlates and association with functional outcome
    • Kiang M, Christensen BK, Remington G, Kapur S (2003) Apathy in schizophrenia: clinical correlates and association with functional outcome. Schizophr Res 63:79-88. doi: 10.1016/S0920-9964(02)00433-4
    • (2003) Schizophr Res , vol.63 , pp. 79-88
    • Kiang, M.1    Christensen, B.K.2    Remington, G.3    Kapur, S.4
  • 29
    • 33751539529 scopus 로고    scopus 로고
    • Apathy and the basal ganglia
    • Levy R, Czernecki V (2006) Apathy and the basal ganglia. J Neurol 253:vii54-vii61. doi: 10.1007/s00415-006-7012-5
    • (2006) J Neurol , vol.253 , pp. vii54-vii61
    • Levy, R.1    Czernecki, V.2
  • 31
    • 84888818072 scopus 로고    scopus 로고
    • Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia
    • Markou A, Salamone JD, Bussey TJ, Mar AC, Brunner D, Gilmour G, Balsam P (2013) Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia. Neurosci Biobehav Rev 37:2149-2165. doi: 10.1016/j.neubiorev.2013.08.007
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 2149-2165
    • Markou, A.1    Salamone, J.D.2    Bussey, T.J.3    Mar, A.C.4    Brunner, D.5    Gilmour, G.6    Balsam, P.7
  • 32
    • 33645230435 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on novel therapeutic strategies
    • Millan MJ (2005) Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60:441-460. doi: 10.2515/therapie:2005065
    • (2005) Therapie , vol.60 , pp. 441-460
    • Millan, M.J.1
  • 33
    • 0034870455 scopus 로고    scopus 로고
    • D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
    • Nowend KL, Arizzi M, Carlson BB, Salamone JD (2001) D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption. Pharmacol Biochem Behav 69:373-382. doi: 10.1016/S0091-3057(01)00524-X
    • (2001) Pharmacol Biochem Behav , vol.69 , pp. 373-382
    • Nowend, K.L.1    Arizzi, M.2    Carlson, B.B.3    Salamone, J.D.4
  • 36
    • 1442264403 scopus 로고    scopus 로고
    • Apathy in schizophrenia: Reduced frontal lobe volume and neuropsychological deficits
    • Roth RM (2004) Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits. Am J Psychiatry 161:157-159. doi: 10.1176/appi.ajp.161.1.157
    • (2004) Am J Psychiatry , vol.161 , pp. 157-159
    • Roth, R.M.1
  • 37
    • 70349116413 scopus 로고    scopus 로고
    • Dopamine, behavioral economics, and effort
    • Salamone JDJD (2009) Dopamine, behavioral economics, and effort. Front Behav Neurosci 3:13. doi: 10.3389/neuro.08.013.2009
    • (2009) Front Behav Neurosci , vol.3 , pp. 13
    • Salamone, J.D.J.D.1
  • 38
    • 0025873242 scopus 로고
    • Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
    • Salamone JD, Steinpreis RE, McCullough LD, Smith P, Grebel D, Mahan K (1991) Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure. Psychopharmacology 104:515-521. doi: 10.1007/bf02245659
    • (1991) Psychopharmacology , vol.104 , pp. 515-521
    • Salamone, J.D.1    Steinpreis, R.E.2    McCullough, L.D.3    Smith, P.4    Grebel, D.5    Mahan, K.6
  • 39
    • 0028605592 scopus 로고
    • Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure
    • Salamone JD, Cousins MS, Bucher S (1994) Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure. Behav Brain Res 65:221-229. doi: 10.1016/0166-4328(94)90108-2
    • (1994) Behav Brain Res , vol.65 , pp. 221-229
    • Salamone, J.D.1    Cousins, M.S.2    Bucher, S.3
  • 40
    • 33847619341 scopus 로고    scopus 로고
    • Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    • Salamone JD, Correa M, Farrar A, Mingote SM (2007) Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology 191:461-482. doi: 10.1007/s00213-006-0668-9
    • (2007) Psychopharmacology , vol.191 , pp. 461-482
    • Salamone, J.D.1    Correa, M.2    Farrar, A.3    Mingote, S.M.4
  • 41
    • 35348814990 scopus 로고    scopus 로고
    • Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward
    • Sanders AC, Hussain AJ, Hen R, Zhuang X (2007) Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward. Neuropsychopharmacology 32:2321-2329. doi: 10.1038/sj.npp.1301368
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2321-2329
    • Sanders, A.C.1    Hussain, A.J.2    Hen, R.3    Zhuang, X.4
  • 43
    • 79953080402 scopus 로고    scopus 로고
    • Anticipatory vs. Consummatory pleasure: What is the nature of hedonic deficits in schizophrenia?
    • Strauss GP, Wilbur RC, Warren KR, August SM, Gold JM (2011) Anticipatory vs. consummatory pleasure: what is the nature of hedonic deficits in schizophrenia? Psychiatry Res 187:36-41. doi: 10.1016/j.psychres.2011.01.012
    • (2011) Psychiatry Res , vol.187 , pp. 36-41
    • Strauss, G.P.1    Wilbur, R.C.2    Warren, K.R.3    August, S.M.4    Gold, J.M.5
  • 44
    • 78649904946 scopus 로고    scopus 로고
    • Reconsidering anhedonia in depression: Lessons from translational neuroscience
    • Treadway MT, Zald DH (2011) Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev 35:537-555. doi: 10.1016/j.neubiorev.2010.06.006
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 537-555
    • Treadway, M.T.1    Zald, D.H.2
  • 45
    • 84878749055 scopus 로고    scopus 로고
    • Parsing anhedonia: Translational models of reward-processing deficits in psychopathology
    • Treadway MT, Zald DH (2013) Parsing anhedonia: translational models of reward-processing deficits in psychopathology. Curr Dir Psychol Sci 22:244-249. doi: 10.1177/0963721412474460
    • (2013) Curr Dir Psychol Sci , vol.22 , pp. 244-249
    • Treadway, M.T.1    Zald, D.H.2
  • 46
    • 68949149875 scopus 로고    scopus 로고
    • Worth the 'EEfRT'? the effort expenditure for rewards task as an objective measure of motivation and anhedonia
    • e6598 10.1371/journal.pone.0006598 2720457 19672310
    • Treadway MT, Buckholtz JW, Schwartzman AN, Lambert WE, Zald DH (2009) Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PLoS ONE 4, e6598. doi: 10.1371/journal.pone.0006598
    • (2009) PLoS ONE , vol.4
    • Treadway, M.T.1    Buckholtz, J.W.2    Schwartzman, A.N.3    Lambert, W.E.4    Zald, D.H.5
  • 48
    • 0033914588 scopus 로고    scopus 로고
    • Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats
    • Vickers SP, Benwell KR, Porter RH, Bickerdike MJ, Kennett GA, Dourish CT (2000) Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. Br J Pharmacol 130:1305-1314. doi: 10.1038/sj.bjp.0703443
    • (2000) Br J Pharmacol , vol.130 , pp. 1305-1314
    • Vickers, S.P.1    Benwell, K.R.2    Porter, R.H.3    Bickerdike, M.J.4    Kennett, G.A.5    Dourish, C.T.6
  • 49
    • 42449164739 scopus 로고    scopus 로고
    • Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: A dose-addition analysis study in mice
    • Ward SJ, Lefever TW, Jackson C, Tallarida RJ, Walker EA (2008) Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice. J Pharmacol Exp Ther 325:567-576. doi: 10.1124/jpet.107.131771
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 567-576
    • Ward, S.J.1    Lefever, T.W.2    Jackson, C.3    Tallarida, R.J.4    Walker, E.A.5
  • 50
    • 33947099919 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: A case-control study
    • Wongpakaran N, van Reekum R, Wongpakaran T, Clarke D (2007) Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: a case-control study. Annals Gen Psychiatr 6:1-6. doi: 10.1186/1744-859x-6-7
    • (2007) Annals Gen Psychiatr , vol.6 , pp. 1-6
    • Wongpakaran, N.1    Van Reekum, R.2    Wongpakaran, T.3    Clarke, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.