Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles

Psychopharmacology

Volumn 226, Issue 3, 2013, Pages 475-490

  Higgins, G A ^a,b   Silenieks, L B ^a   Lau, W ^a   De Lannoy, I A M ^c   Lee, D K H ^c   Izhakova, J ^c   Coen, K ^d   Le, A D ^b,d   Fletcher, P J ^d,e  

^a InterVivo Solutions Inc   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c NoAb BioDiscoveries   (Canada)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HT 2C agonist; CP 809101; Functional selectivity; Lorcaserin; Nausea; Nicotine self administration; Pharmacokinetics; Rat; Ro 60 0175

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; [2 (3 CHLOROBENZYLOXY) 6 (PIPERAZIN 1 YL)PYRAZINE]; CP 809101; LORCASERIN; NICOTINE; ROLIPRAM; SEROTONIN 2C AGONIST; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SELF ADMINISTRATION; FEEDING BEHAVIOR; HYPOLOCOMOTION; MALE; MASTICATION; NONHUMAN; PRIORITY JOURNAL; PTOSIS; RAT; TOBACCO DEPENDENCE;

ANIMALS; BEHAVIOR, ANIMAL; BENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; FEEDING BEHAVIOR; INDOLES; MALE; MOTIVATION; NICOTINE; PIPERAZINES; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 84876470735     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2919-2     Document Type: Article

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