메뉴 건너뛰기




Volumn , Issue , 2012, Pages 23-35

Molecular pharmacology of CXCR4 inhibition

Author keywords

AMD3100; G CSF; Mobilization; Progenitor cells; Stem cells

Indexed keywords


EID: 84955374995     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-1960-0_2     Document Type: Chapter
Times cited : (5)

References (40)
  • 1
    • 0037020329 scopus 로고    scopus 로고
    • Sign strategies for targeting g-protein-coupled receptors
    • Klabunde T, Hessler G (2002) Drug design strategies for targeting G-protein-coupled receptors. Chembiochem 3(10):928-944. doi:10.1002/1439-7633(20021004)3:10928:AID-CBIC9283.0.CO;2-5.
    • (2002) Chembiochem , vol.3 , Issue.10 , pp. 928-944
    • Klabunde, T.1    Hessler, G.2
  • 3
  • 4
    • 77449147872 scopus 로고    scopus 로고
    • The role of transmembrane segment ii in 7tm receptor activation
    • Benned-Jensen T, Rosenkilde MM (2009) The role of transmembrane segment II in 7TM receptor activation. Curr Mol Pharmacol 2(2):140-148.
    • (2009) Curr Mol Pharmacol , vol.2 , Issue.2 , pp. 140-148
    • Benned-Jensen, T.1    Rosenkilde, M.M.2
  • 5
    • 0029898348 scopus 로고    scopus 로고
    • Is there a “lock” for all agonist “keys” in 7tm receptors?
    • Schwartz TW, Rosenkilde MM (1996) Is there a “lock” for all agonist “keys” in 7TM receptors? Trends Pharmacol Sci 17(6):213-216. doi:0165614796100171.
    • (1996) Trends Pharmacol Sci , vol.17 , Issue.6 , pp. 213-216
    • Schwartz, T.W.1    Rosenkilde, M.M.2
  • 7
    • 0037285444 scopus 로고    scopus 로고
    • Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking
    • Hubbell WL, Altenbach C, Hubbell CM, Khorana HG (2003) Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking. Adv Protein Chem 63:243-290.
    • (2003) Adv Protein Chem , vol.63 , pp. 243-290
    • Hubbell, W.L.1    Altenbach, C.2    Hubbell, C.3    Khorana, H.G.4
  • 8
    • 44949236117 scopus 로고    scopus 로고
    • High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
    • Altenbach C, Kusnetzow AK, Ernst OP, Hofmann KP, Hubbell WL (2008) High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc Natl Acad Sci USA 105(21):7439-7444. doi:080251510510.1073/pnas.0802515105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.21 , pp. 7439-7444
    • Altenbach, C.1    Kusnetzow, A.K.2    Ernst, O.P.3    Hofmann, K.P.4    Hubbell, W.L.5
  • 10
    • 47049130668 scopus 로고    scopus 로고
    • Crystal structure of the
    • Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP (2008) Crystal structure of the ligandfree G-protein-coupled receptor opsin. Nature 454(7201):183-187. doi:nature07063 10.1038/nature07063.
    • (2008) Nature , vol.454 , Issue.7201 , pp. 183-187
    • Park, J.H.1    Scheerer, P.2    Hofmann, K.P.3    Choe, H.W.4    Ernst, O.P.5
  • 15
    • 77949884096 scopus 로고    scopus 로고
    • Targeting cxcr4 in hiv cell-entry inhibition
    • Steen A, Schwartz TW, Rosenkilde MM (2009) Targeting CXCR4 in HIV cell-entry inhibition. Mini Rev Med Chem 9:1605-1621. doi:MRMC Epub-055.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 1605-1621
    • Steen, A.1    Schwartz, T.W.2    Rosenkilde, M.M.3
  • 16
    • 1542582866 scopus 로고    scopus 로고
    • Thermodynamic and kinetic data for macrocycle interactions with cations and anions
    • Izatt RM, Pawlak K, Bradshaw JS, Bruening RL (1991) Thermodynamic and kinetic data for macrocycle interactions with cations and anions. Chem Rev 91(8):1721-2085. doi:10.1021/cr00008a003.
    • Chem Rev , vol.91 , Issue.8 , pp. 1721-2085
    • Izatt, R.M.1    Pawlak, K.2    Bradshaw, J.3    Bruening, R.L.4
  • 18
    • 0031927202 scopus 로고    scopus 로고
    • Determinants for sensitivity of human immunodeficiency virus coreceptor cxcr4 to the bicyclam amd3100
    • Labrosse B, Brelot A, Heveker N, Sol N, Schols D, De Clercq E, Alizon M (1998) Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100. J Virol 72(8):6381-6388.
    • (1998) J Virol , vol.72 , Issue.8 , pp. 6381-6388
    • Labrosse, B.1    Brelot, A.2    Heveker, N.3    Sol, N.4    Schols, D.5    De Clercq, E.6    Alizon, M.7
  • 19
    • 0027933763 scopus 로고
    • Locating ligand-binding sites in 7tm receptors by protein engineering
    • Schwartz TW (1994) Locating ligand-binding sites in 7TM receptors by protein engineering. Curr Opin Biotechnol 5(4):434-444.
    • (1994) Curr Opin Biotechnol , vol.5 , Issue.4 , pp. 434-444
    • Schwartz, T.W.1
  • 20
    • 0027506471 scopus 로고
    • The probable arrangement of the helices in g protein-coupled receptors
    • Baldwin JM (1993) The probable arrangement of the helices in G protein-coupled receptors. EMBO J 12(4):1693-1703.
    • (1993) EMBO J , vol.12 , Issue.4 , pp. 1693-1703
    • Baldwin, J.M.1
  • 21
    • 0035957911 scopus 로고    scopus 로고
    • Molecular interactions of cyclam and bicyclam non-peptide antagonists with the cxcr4 chemokine receptor
    • Gerlach LO, Skerlj RT, Bridger GJ, Schwartz TW (2001) Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J Biol Chem 276(17): 14153-14160. doi:10.1074/jbc.M010429200 M010429200.
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 14153-14160
    • Gerlach, L.O.1    Skerlj, R.T.2    Bridger, G.J.3    Schwartz, T.W.4
  • 25
    • 1642535388 scopus 로고    scopus 로고
    • Molecular mechanism of amd3100 antagonism in the cxcr4 receptor: Transfer of binding site to the cxcr3 receptor
    • Rosenkilde MM, Gerlach LO, Jakobsen JS, Skerlj RT, Bridger GJ, Schwartz TW (2004) Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem 279(4):3033-3041. doi:10.1074/jbc.M309546200 M309546200.
    • (2004) J Biol Chem , vol.279 , Issue.4 , pp. 3033-3041
    • Rosenkilde, M.M.1    Gerlach, L.O.2    Jakobsen, J.S.3    Skerlj, R.T.4    Bridger, G.J.5    Schwartz, T.W.6
  • 26
    • 0037063329 scopus 로고    scopus 로고
    • Chemokinereceptor inhibition by amd3100is strictly confined to cxcr4
    • Hatse S, Princen K, Bridger G, De Clercq E, Schols D (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 527(1-3):255-262. doi: S0014579302031435.
    • (2002) FEBS Lett , vol.527 , Issue.1-3 , pp. 255-262
    • Hatse, S.1    Princen, K.2    Bridger, G.3    De Clercq, E.4    Schols, D.5
  • 27
    • 0030046536 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of phenylenebis(Methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication
    • Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Joao HC, Witvrouw M, De Vreese K, Pauwels R, De Clercq E (1996) Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicy- clams. J Med Chem 39(1):109-119. doi:10.1021/jm950584t jm950584t.
    • (1996) J Med Chem , vol.39 , Issue.1 , pp. 109-119
    • Bridger, G.J.1    Skerlj, R.T.2    Padmanabhan, S.3    Martellucci, S.A.4    Henson, G.W.5    Abrams, M.J.6    Joao, H.C.7    Witvrouw, M.8    De Vreese, K.9    Pauwels, R.10    De Clercq, E.11
  • 28
    • 0029086827 scopus 로고
    • Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of hiv-1 and hiv-2 inhibitors
    • Joao HC, De Vreese K, Pauwels R, De Clercq E, Henson GW, Bridger GJ (1995) Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors. J Med Chem 38(19):3865-3873.
    • (1995) J Med Chem , vol.38 , Issue.19 , pp. 3865-3873
    • Joao, H.C.1    De Vreese, K.2    Pauwels, R.3    De Clercq, E.4    Henson, G.W.5    Bridger, G.J.6
  • 29
    • 34848834558 scopus 로고    scopus 로고
    • Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the cxcr4 chemokine receptor
    • Rosenkilde MM, Gerlach LO, Hatse S, Skerlj RT, Schols D, Bridger GJ, Schwartz TW (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem 282(37):27354-27365. doi:M70473920010.1074/jbc.M704739200.
    • (2007) J Biol Chem , vol.282 , Issue.37 , pp. 27354-27365
    • Rosenkilde, M.M.1    Gerlach, L.O.2    Hatse, S.3    Skerlj, R.T.4    Schols, D.5    Bridger, G.J.6    Schwartz, T.W.7
  • 30
    • 57349105727 scopus 로고    scopus 로고
    • Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule cxc
    • Wong RS, Bodart V, Metz M, Labrecque J, Bridger G, Fricker SP (2008) Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors. Mol Pharmacol 74(6):1485-1495. doi:mol.108.04977510.1124/mol. 108.049775.
    • (2008) Mol Pharmacol , vol.74 , Issue.6 , pp. 1485-1495
    • Wong, R.S.1    Bodart, V.2    Metz, M.3    Labrecque, J.4    Bridger, G.5    Fricker, S.P.6
  • 35
    • 68749088365 scopus 로고    scopus 로고
    • The cxcr4 antagonist 4f-benzoyl-tn14003 stimulates the recovery of the bone marrow after transplantation
    • Abraham M, Beider K, Wald H, Weiss ID, Zipori D, Galun E, Nagler A, Eizenberg O, Peled A (2009) The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation. Leukemia 23(8):1378-1388. doi:leu20095610.1038/leu.2009.56.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1378-1388
    • Abraham, M.1    Beider, K.2    Wald, H.3    Weiss, I.D.4    Zipori, D.5    Galun, E.6    Nagler, A.7    Eizenberg, O.8    Peled, A.9
  • 36
    • 0344012474 scopus 로고    scopus 로고
    • Lipid bilayer simulations of cxcr4 with inverse agonists and weak partial agonists
    • Trent JO, Wang ZX, Murray JL, Shao W, Tamamura H, Fujii N, Peiper SC (2003) Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem 278(47):47136-47144. doi:10.1074/jbc.M307850200 M307850200.
    • (2003) J Biol Chem , vol.278 , Issue.47 , pp. 47136-47144
    • Trent, J.O.1    Wang, Z.X.2    Murray, J.L.3    Shao, W.4    Tamamura, H.5    Fujii, N.6    Peiper, S.C.7
  • 37
    • 0034606466 scopus 로고    scopus 로고
    • Pharmacophore identification of a specific cxcr4 inhibitor, t140, leads to development of effective anti-hiv agents with very high selectivity indexes
    • Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N (2000) Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorg Med Chem Lett 10(23):2633-2637. doi:S0960-894X(00)00535-7.
    • (2000) Bioorg Med Chem Lett , vol.10 , Issue.23 , pp. 2633-2637
    • Tamamura, H.1    Omagari, A.2    Oishi, S.3    Kanamoto, T.4    Yamamoto, N.5    Peiper, S.C.6    Nakashima, H.7    Otaka, A.8    Fujii, N.9
  • 38
    • 33749518297 scopus 로고    scopus 로고
    • A minimalistic 3d pharmacophore model for cyclopentapeptide cxcr4 antagonists
    • Vabeno J, Nikiforovich GV, Marshall GR (2006) A minimalistic 3D pharmacophore model for cyclopentapeptide CXCR4 antagonists. Biopolymers 84(5):459-471. doi:10.1002/bip. 20508.
    • (2006) Biopolymers , vol.84 , Issue.5 , pp. 459-471
    • Vabeno, J.1    Nikiforovich, G.V.2    Marshall, G.R.3
  • 39
    • 33745216928 scopus 로고    scopus 로고
    • Insight into the binding mode for cyclopentapeptide antagonists of the cxcr4 receptor
    • Vabeno J, Nikiforovich GV, Marshall GR (2006) Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor. Chem Biol Drug Des 67(5):346-354. doi:JPP38710.1111/j. 1747-0285.2006.00387.x.
    • (2006) Chem Biol Drug , vol.67 , Issue.5 , pp. 346-354
    • Vabeno, J.1    Nikiforovich, G.V.2    Marshall, G.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.