Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr5,12, Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 7, 1998, Pages 1033-1041

  Tamamura, Hirokazu ^a   Imai, Makoto ^a   Ishihara, Tsunehito ^a   Masuda, Masao ^a   Funakoshi, Hanae ^a   Oyake, Hiromi ^a   Murakami, Tsutomu ^b   Arakaki, Rieko ^c   Nakashima, Hideki ^c   Otaka, Akira ^a   Ibuka, Toshiro ^a   Waki, Michinori ^d   Matsumoto, Akiyoshi ^d   Yamamoto, Naoki ^b   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d SEIKAGAKU CORPORATION   (Japan)

Author keywords

Anti HIV peptide; CXCR4 inhibitor; T22; Tachyplesin

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR; PEPTIDE DERIVATIVE; POLYPHEMUSIN II[5 TYROSINE 12 TYROSINE 7 LYSINE]; RECEPTOR BLOCKING AGENT; TACHYPLESIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE; CIRCULAR DICHROISM; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031693633     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00061-3     Document Type: Article

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