TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

Journal of Neurochemistry

Volumn 136, Issue 3, 2016, Pages 620-636

  Gao, Lei ^a   Tian, Mi ^a   Zhao, Hong Yun ^b   Xu, Qian Qian ^a   Huang, Yu Ming ^a   Si, Qun Cao ^a   Tian, Qing ^a   Wu, Qing Ming ^a   Hu, Xia Min ^a   Sun, Li Bo ^a   McClintock, Shawn M ^a,c,d   Zeng, Yan ^a  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Armed Police Hospital of Hangzhou   (China)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

7, 8 dihydroxyflavone; AMPA receptors; cognitive impairment; synapse structure; Tg2576 mouse; TrkB signaling

Indexed keywords

7,8 DIHYDROXYFLAVONE; AMPA RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR A1; GLUTAMATE RECEPTOR A2; PROTEIN TYROSINE KINASE; TYROSINE RECEPTOR KINASE B; UNCLASSIFIED DRUG; 7,8-DIHYDROXYFLAVANONE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; FLAVANONE DERIVATIVE; PROTEIN KINASE B; PROTEIN SUBUNIT;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME ASSAY; HIPPOCAMPUS; IN VIVO STUDY; MALE; MEMORY DISORDER; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPATIAL MEMORY; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MAZE TEST; MEMORY DISORDERS; METABOLISM; MUTATION; PATHOLOGY; PROTEIN SUBUNIT; SYNAPSE; SYNAPTOSOME; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FLAVANONES; GENE EXPRESSION REGULATION; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, TRKB; RECEPTORS, AMPA; SYNAPSES; SYNAPTOSOMES;

EID: 84955370322     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13432     Document Type: Article

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