A live-cell, high-content imaging survey of 206 endogenous factors across five stress conditions reveals context-dependent survival effects in mouse primary beta cells

Diabetologia

Volumn 58, Issue 6, 2015, Pages 1239-1249

  Yang, Yu Hsuan Carol ^a,b,c   Wills, Quin F ^a,b,c   Johnson, James D ^a,b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Autocrine paracrine signalling; Beta cell apoptosis; ER stress; High throughput screening; Islets

Indexed keywords

GAMMA INTERFERON; GLUCOSE; GREEN FLUORESCENT PROTEIN; INSULIN; INTERLEUKIN 1BETA; PALMITIC ACID DERIVATIVE; THAPSIGARGIN; TUMOR NECROSIS FACTOR;

ANIMAL; APOPTOSIS; BIOLOGY; CELL CULTURE; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; HUMAN; METABOLISM; MIDDLE AGED; MOUSE; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GREEN FLUORESCENT PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MICE; MIDDLE AGED; PALMITATES; SIGNAL TRANSDUCTION; THAPSIGARGIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939998465     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3552-5     Document Type: Article

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