NEDDylation promotes endothelial dysfunction: A role for HDAC2

Journal of Molecular and Cellular Cardiology

Volumn 81, Issue , 2015, Pages 18-22

  Pandey, Deepesh ^a   Hori, Daijiro ^a   Kim, Jae Hyung ^a   Bergman, Yehudit ^a   Berkowitz, Dan E ^a,b   Romer, Lewis H ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

Author keywords

Atherosclerosis; Endothelial dysfunction; NEDDylation; Protein degradation; Ubiquitination; Vascular endothelium

Indexed keywords

ARGINASE; ARGINASE 2; ENZYME; HISTONE DEACETYLASE 2; NEDD8 PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PEVONEDISTAT; PROTEIN SENP8; UNCLASSIFIED DRUG; ((1S,2S,4R)-4-(4-((1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-7H-PYRROLO(2,3-D)PYRIMIDIN-7-YL)-2-HYDROXYCYCLOPENTYL)METHYL SULPHAMATE; ARGINASE II, HUMAN; CYCLOPENTANE DERIVATIVE; ENZYME INHIBITOR; HDAC2 PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN; NEDD8 PROTEIN, HUMAN; PROTEASOME; PROTEINASE; PYRIMIDINE DERIVATIVE; SENP8 PROTEIN, HUMAN; UBIQUITIN;

ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; CONJUGATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; EX VIVO STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NEDDYLATION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UPREGULATION; VASCULAR HOMEOSTASIS; ANIMAL; AORTA; ATHEROSCLEROSIS; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUE; UBIQUITINATION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; ARGINASE; ATHEROSCLEROSIS; CELL LINE; CYCLOPENTANES; ENDOPEPTIDASES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HISTONE DEACETYLASE 2; HUMANS; LIPOPROTEINS, LDL; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PYRIMIDINES; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; UBIQUITINATION; UBIQUITINS;

EID: 84922373736     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.01.019     Document Type: Article

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