Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Kurhade, Chaitanya ^a   Zegenhagen, Loreen ^b   Weber, Elvira ^a,f   Nair, Sharmila ^b,g   Michaelsen Preusse, Kristin ^c   Spanier, Julia ^d   Gekara, Nelson O ^a   Kröger, Andrea ^b,e   Överby, Anna K ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g WASHINGTON UNIVERSITY   (United States)

Author keywords

Antiviral mechanism; Brain; Immune evasion; IPS 1; Olfactory bulb; Tick borne encephalitis; Type I interferons

Indexed keywords

ADAPTOR PROTEIN; INTERFERON; IPS 1 PROTEIN; STAT1 PROTEIN; TYPE I INTERFERON; UNCLASSIFIED DRUG; IPS-1 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN REGION; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESPONSE; ENCEPHALITIS; HEMORRHAGIC FEVER; INFLAMMATION; INNATE IMMUNITY; LANGAT VIRUS; MENINGITIS; MICROGLIA; MOUSE; NONHUMAN; OLFACTORY BULB; PATHOGENICITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TICK BORNE FLAVIVIRUS; VIRAL TROPISM; VIRUS LOAD; VIRUS REPLICATION; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; T LYMPHOCYTE; TICK BORNE ENCEPHALITIS; TICK BORNE ENCEPHALITIS VIRUS; TIME FACTOR; VIROLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; GENE EXPRESSION REGULATION, VIRAL; HIPPOCAMPUS; INTERFERON TYPE I; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; OLFACTORY BULB; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; VIRUS REPLICATION;

EID: 84955320336     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0487-9     Document Type: Article

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