Type I interferon protects mice from fatal neurotropic infection with langat virus by systemic and local antiviral responses

Journal of Virology

Volumn 88, Issue 21, 2014, Pages 12202-12212

  Weber, Elvira ^a,e   Finsterbusch, Katja ^b,f   Lindquist, Richard ^a   Nair, Sharmila ^b   Lienenklaus, Stefan ^b   Gekara, Nelson O ^a   Janik, Dirk ^c   Weiss, Siegfried ^b   Kalinke, Ulrich ^d   Överby, Anna K ^a   Kröger, Andrea ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^e UNIVERSITY OF BONN   (Germany)

^f CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON; NONSTRUCTURAL PROTEIN 5; VIRUS RNA; INTERFERON RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; ENCEPHALITIS; FLAVIVIRUS; FLAVIVIRUS INFECTION; IN VIVO STUDY; MACROPHAGE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SURVIVAL RATE; SURVIVAL TIME; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIROGENESIS; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; C57BL MOUSE; DEFICIENCY; IMMUNOLOGY; KNOCKOUT MOUSE; MORTALITY; SURVIVAL; TICK BORNE ENCEPHALITIS; TICK BORNE ENCEPHALITIS VIRUS;

ANIMALS; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; INTERFERON TYPE I; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERFERON; SURVIVAL ANALYSIS;

EID: 84907963247     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01215-14     Document Type: Article

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