An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo

Virology

Volumn 435, Issue 2, 2013, Pages 269-280

  Wollish, Amy C ^a,b   Ferris, Martin T ^a,b   Blevins, Lance K ^a,b   Loo, Yueh Ming ^c   Gale, Michael ^c   Heise, Mark T ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Alphavirus; Interferon; IPS 1; Neurovirulence; Pattern recognition receptors; Sindbis

Indexed keywords

INTERFERON; MYELOID DIFFERENTIATION FACTOR 88; NONSTRUCTURAL PROTEIN 1; PROTEIN IPS 1; RIG I LIKE RECEPTOR; THREONINE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATING MUTATION; CONTROLLED STUDY; ENCEPHALOMYELITIS; FEMALE; GENE MUTATION; IN VIVO STUDY; MOUSE; NEUROVIRULENCE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINDBIS VIRUS; STRAIN DIFFERENCE; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALPHAVIRUS INFECTIONS; ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; FEMALE; GENE EXPRESSION REGULATION; INTERFERON TYPE I; MICE; MICE, INBRED C57BL; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; SINDBIS VIRUS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

ALPHAVIRUS; MUS; SINDBIS VIRUS;

EID: 84871708971     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2012.09.008     Document Type: Article

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