Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

PLoS Pathogens

Volumn 10, Issue 3, 2014, Pages

  Nair, Sharmila ^a   Michaelsen Preusse, Kristin ^b   Finsterbusch, Katja ^a   Stegemann Koniszewski, Sabine ^a   Bruder, Dunja ^a,c   Grashoff, Martina ^a   Korte, Martin ^a,b   Köster, Mario ^a   Kalinke, Ulrich ^d   Hauser, Hansjörg ^a   Kröger, Andrea ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; MESSENGER RNA; NEUROTROPIC AGENT; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BRAIN; CELL ISOLATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE INDUCTION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A; INNATE IMMUNITY; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; VESICULAR STOMATITIS VIRUS; VIRUS NEUTRALIZATION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; INTERFERON REGULATORY FACTOR-1; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; VESICULAR STOMATITIS; VESICULOVIRUS; VIRUS REPLICATION;

EID: 84897382155     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003999     Document Type: Article

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