Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

eLife

Volumn 4, Issue September2015, 2015, Pages

  Keedy, Daniel A ^a   Kenner, Lillian R ^a   Warkentin, Matthew ^b   Woldeyes, Rahel A ^a   Hopkins, Jesse B ^b   Thompson, Michael C ^a   Brewster, Aaron S ^c   Benschoten, Andrew H Van ^a   Baxter, Elizabeth L ^d   Uervirojnangkoorn, Monarin ^e   McPhillips, Scott E ^d   Song, Jinhu ^d   Alonso Mori, Roberto ^f   Holton, James M ^a,c,d   Weis, William I ^e,f   Brunger, Axel T ^e,f   Soltis, S Michael ^d   Lemke, Henrik ^f   Gonzalez, Ana ^d   Sauter, Nicholas K ^c   Cohen, Aina E ^d   van den Bedem, Henry ^d   Thorne, Robert E ^b   Fraser, James S ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b School of Chemical and Molecular Engineering   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^e STANFORD UNIVERSITY   (United States)

^f SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME POLYMORPHISM; MOLECULAR DYNAMICS; MULTITEMPERATURE SYNCHROTRON CRYSTALLOGRAPHY; RADIATION INJURY; TEMPERATURE; X-RAY FREE-ELECTRON LASER CRYSTALLOGRAPHY; CHEMISTRY; HUMAN; MOLECULAR MODEL; PROTEIN CONFORMATION; RADIATION RESPONSE; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILIN A; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; TEMPERATURE;

EID: 84955277953     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.07574.001     Document Type: Article

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