Crystal cryocooling distorts conformational heterogeneity in a model michaelis complex of DHFR

Structure

Volumn 22, Issue 6, 2014, Pages 899-910

  Keedy, Daniel A ^a   Van Den Bedem, Henry ^b   Sivak, David A ^a   Petsko, Gregory A ^c,d   Ringe, Dagmar ^d   Wilson, Mark A ^e   Fraser, James S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^c BRANDEIS UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; ESCHERICHIA COLI PROTEIN;

ARTICLE; CRYSTAL CRYOCOOLING; CRYSTAL STRUCTURE; ENERGY; GENETIC PROCEDURES; HYDROGEN BOND; MACROMOLECULE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN POLYMORPHISM; ROOM TEMPERATURE; TEMPERATURE DEPENDENCE; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; COLD; CRYSTALLIZATION; ENZYMOLOGY; ESCHERICHIA COLI; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY;

COLD TEMPERATURE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84902319994     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.04.016     Document Type: Article

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