Progress in Understanding the Genetic Information and Biosynthetic Pathways behind Amycolatopsis Antibiotics, with Implications for the Continued Discovery of Novel Drugs

ChemBioChem

Volumn 17, Issue 2, 2016, Pages 119-128

  Chen, Su ^a   Wu, Qihao ^a   Shen, Qingqing ^a   Wang, Hong ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Amycolatopsis; antibiotics; biosynthesis; chemical structures; genome sequences

Indexed keywords

13 HYDROXY 2,12,14,16,22 PENTAMETHYL 28 ( N METHYL GUANIDINO)OCTACOSA 2,4,6,8,10,14,20,24 OCTAENOIC ACID (2 HYDROXY 5 OXO CYCLOPENT 1 ENYL) AMIDE; ANTIBIOTIC AGENT; AVOPARCIN; BALHIMYCIN; CHELOCARDINHELOCARDIN; DECHLOROEREMOMYCIN; GLYCOPEPTIDE; POLYENE ANTIBIOTIC AGENT; RIFAMYCIN; RIFAMYCIN B; RISTOCETIN; RISTOCETIN A; RISTOCETIN B; TEICOPLANIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; RIFAMPICIN;

AMYCOLATOPSIS; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GENOME; BIOSYNTHESIS; CARBOHYDRATE ANALYSIS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CHROMOSOME WALKING; CYCLIZATION; GENE CLUSTER; GENE SEQUENCE; GENETIC MANIPULATION; GLYCOSYLATION; HALOGENATION; HETEROLOGOUS EXPRESSION; METHYLATION; MOLECULAR GENETICS; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CROSS LINKING; PROTEIN SYNTHESIS; THROMBOCYTE AGGLUTINATION; THROMBOCYTE AGGREGATION; VANCOMYCIN RESISTANT ENTEROCOCCUS; ACTINOMYCETALES; CHEMISTRY; DRUG DEVELOPMENT;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; DRUG DISCOVERY; RIFAMPIN; VANCOMYCIN;

EID: 84955205313     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500542     Document Type: Article

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