Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

FEBS Letters

Volumn 586, Issue 15, 2012, Pages 2171-2176

  Wohlleben, Wolfgang ^a   Mast, Yvonne ^a   Muth, Günther ^a   Röttgen, Marlene ^a   Stegmann, Evi ^a   Weber, Tilmann ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antibiotic; Gene transfer; Non proteinogenic amino acid; Precursor supply; Synthetic Biology

Indexed keywords

AMINO ACID; ANSATRIENIN; ANTIBIOTIC AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BALHIMYCIN; CHLOROEREMOMYCIN; COMPLESTATIN; DALBAVANCIN; NAPHTHOMYCIN; NATURAL PRODUCT; POLYPEPTIDE ANTIBIOTIC AGENT; PRISTINAMYCIN; RIFAMYCIN W; STREPTOGRAMIN DERIVATIVE; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ACTINOBACTERIA; ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL METABOLISM; BETA HT GENE; BIOENGINEERING; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; DNA SEQUENCE; DPG GENE; DRUG SYNTHESIS; GENE TRANSFER; GENETIC VARIABILITY; HPG GENE; METABOLITE; MOLECULAR EVOLUTION; NOCARDIA ORIENTALIS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SYNTHETIC BIOLOGY;

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; EVOLUTION, MOLECULAR; GENE TRANSFER, HORIZONTAL; MULTIGENE FAMILY; SYNTHETIC BIOLOGY;

ACTINOBACTERIA (CLASS);

EID: 84863615074     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.04.025     Document Type: Review

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