Genomic analyses lead to novel secondary metabolites: Part 3 ECO-0501, a novel antibacterial of a new class

Journal of Antibiotics

Volumn 59, Issue 9, 2006, Pages 533-542

  Banskota, Arjun H ^a   McAlpine, James B ^a   Sørensen, Dan ^a   Ibrahim, Ashraf ^a   Aouidate, Mustapha ^a   Piraee, Mahmood ^a   Alarco, Anne Marie ^a   Farnet, Chris M ^a   Zazopoulos, Emmanuel ^a  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Amycolatopsis orientalis; Antibacterial; ECO 0501; PKS I

Indexed keywords

13 HYDROXY 2,12,14,16,22 PENTAMETHYL 28 (N METHYLGUANIDINO)OCTACOSA 2,4,6,8,10,14,20,24 OCTAENOIC ACID(2 HYDROXY 5 OXO CYCLOPENT 1 ENYL)AMIDE; AMPHOTERICIN; ANTIINFECTIVE AGENT; CIRRAMYCIN; DRUG METABOLITE; ECO 0501; ERYTHROMYCIN; MEGALOMICIN; METHYMYCIN; NATAMYCIN; NIDDAMYCIN; NYSTATIN; OLEANDOMYCIN; PIKROMYCIN; POLYKETIDE SYNTHASE; ROSARAMICIN; TYLOSIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ACETYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; ESTERIFICATION; GENE CLUSTER; GENE LOCUS; GENETIC ANALYSIS; GENOMICS; HYDROGENATION; METABOLITE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; DNA, BACTERIAL; ENTEROCOCCUS; FATTY ACIDS, UNSATURATED; GENES, BACTERIAL; GENOMICS; GUANIDINES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHICILLIN RESISTANCE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN RESISTANCE;

AMYCOLATOPSIS ORIENTALIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA;

EID: 33751254066     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.74     Document Type: Article

References (15)

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