Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering

Angewandte Chemie - International Edition

Volumn 54, Issue 13, 2015, Pages 3937-3940

  Lešnik, Urška ^a,h,i   Lukežič, Tadeja ^a   Podgoršek, Ajda ^a,g   Horvat, Jaka ^a   Polak, Tomaž ^b   Šala, Martin ^c   Jenko, Branko ^a,g   Harmrolfs, Kirsten ^h,i   Ocampo Sosa, Alain ^f   Martínez Martínez, Luis ^d   Herron, Paul R ^e   Fujs, Štefan ^a   Kosec, Gregor ^a,g   Hunter, Iain S ^e   Müller, Rolf ^h,i   Petkovic, Hrvoje ^a  

^a ACIES BIO D O O   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^f HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^g Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins   (Slovenia)

^h SAARLAND UNIVERSITY   (Germany)

ⁱ HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

antibiotics; biosynthesis; chelocardin; polyketides; tetracyclines

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL MODIFICATION; GENETIC ENGINEERING; SCAFFOLDS;

ANTIMICROBIAL RESISTANCES; BIOSYNTHETIC ENGINEERINGS; BROAD SPECTRUM ANTIBIOTICS; CHELOCARDIN; GRAM-NEGATIVE PATHOGENS; PHARMACOLOGICAL PROPERTIES; POLYKETIDES; TETRACYCLINES;

ANTIBIOTICS;

ANTIINFECTIVE AGENT; TETRACYCLINE DERIVATIVE;

ANTIBIOTIC RESISTANCE; CONFORMATION; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MEDICINAL CHEMISTRY; MICROBIAL SENSITIVITY TEST; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG RESISTANCE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PROTEIN ENGINEERING; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINES;

EID: 84924918001     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201411028     Document Type: Article

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