First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis

ACS Chemical Biology

Volumn 11, Issue 1, 2016, Pages 172-184

  Palde, Prakash B ^a   Bhaskar, Ashima ^b   Pedró Rosa, Laura E ^a   Madoux, Franck ^a   Chase, Peter ^a   Gupta, Vinayak ^a   Spicer, Timothy ^a   Scampavia, Louis ^a   Singh, Amit ^b   Carroll, Kate S ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

APS REDUCTASE INHIBITOR; CYSTEINE; OXIDOREDUCTASE INHIBITOR; SULFATE; SULFUR; UNCLASSIFIED DRUG; ADENYLYLSULFATE REDUCTASE; OXIDOREDUCTASE; SULFUR DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; BIOSYNTHESIS; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; METABOLISM; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PATHOGENESIS; PRIORITY JOURNAL; SURVIVAL; TUBERCULOSIS; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HIGH THROUGHPUT SCREENING; PRECLINICAL STUDY; REPRODUCIBILITY; SYNTHESIS;

ANIMALS; ANTITUBERCULAR AGENTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; REPRODUCIBILITY OF RESULTS; SULFUR; SULFUR COMPOUNDS; TUBERCULOSIS;

EID: 84955146754     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00517     Document Type: Article

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