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Volumn 325, Issue 5946, 2009, Pages 1380-1384

Endogenous nitric oxide protects bacteria against a wide spectrum of antibiotics

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; ANTIBIOTIC AGENT; CEFUROXIME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYOCYANINE; TOXIC SUBSTANCE;

EID: 70249096979     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1175439     Document Type: Article
Times cited : (326)

References (28)
  • 9
    • 70249144819 scopus 로고    scopus 로고
    • note
    • 2+) (U, 12). Also, NO autoxidation is accelerated markedly due to the process of micellar catalysis, which is mediated by proteins' hydrophobic pockets and membranes in vivo (10).
  • 18
    • 0029035765 scopus 로고
    • L. G. Rahme et al, Science 268, 1899 (1995).
    • (1899) Science , vol.268 , pp. 1995
    • Rahme, L.G.1
  • 21
    • 70249122142 scopus 로고    scopus 로고
    • note
    • B. subtilis catabolizes glucose and other sugars to pyruvate during exponential growth (26). Instead of oxidizing pyruvate further, they excrete it as acetoin, thereby limiting the respiratory chain activity (26). In contrast, during the stationary phase, acetoin is reused from the media leading to the increase of oxidative phosphorylation.
  • 24
    • 70249133799 scopus 로고    scopus 로고
    • note
    • - per hour (-100 nM/min) is a large increase. Previously we demonstrated that only a single treatment with 30 pM NO renders cells resistant to oxidative stress (4). Sustained NO production at higher levels is toxic [e.g., (27)]. Cells need to produce the optimal level of NO in response to toxins, enough to suppress the Fenton reaction, but not enough to affect the respiratory chain and glycolysis.
  • 28
    • 70249093732 scopus 로고    scopus 로고
    • This research was supported by the NIH Director's Pioneer Award to E.N. 10.1126/science.1175439
    • This research was supported by the NIH Director's Pioneer Award to E.N. 10.1126/science.1175439


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.