-
1
-
-
0032515068
-
Mycothiol biosynthesis and metabolism: Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol
-
Anderberg S, Newton GL, Fahey RC (1998) Mycothiol biosynthesis and metabolism: Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol. J Biol Chem 273:30391-30397
-
(1998)
J Biol Chem
, vol.273
, pp. 30391-30397
-
-
Anderberg, S.1
Newton, G.L.2
Fahey, R.C.3
-
2
-
-
0016688679
-
Isolation and initial characterization of glutathione-deficient mutants of Escherichia coli K 12
-
Apontoweil P, Berends W (1975) Isolation and initial characterization of glutathione-deficient mutants of Escherichia coli K 12. Biochim Biophys Acta 399:10-22
-
(1975)
Biochim Biophys Acta
, vol.399
, pp. 10-22
-
-
Apontoweil, P.1
Berends, W.2
-
3
-
-
0034532221
-
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme
-
Bohme CC, Arscott LD, Becker K, Schirmer RH, Williams CH, Jr. (2000) Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. J Biol Chem 275:37317-37323
-
(2000)
J Biol Chem
, vol.275
, pp. 37317-37323
-
-
Bohme, C.C.1
Arscott, L.D.2
Becker, K.3
Schirmer, R.H.4
Williams C.H., Jr.5
-
4
-
-
0030792817
-
Biosynthesis of mycothiol: Elucidation of the sequence of steps in Mycobacterium smegmatis
-
Bornemann C, Jardine MA, Spies HSC, Steenkamp DJ (1997) Biosynthesis of mycothiol: Elucidation of the sequence of steps in Mycobacterium smegmatis. Biochem J 325:623-629
-
(1997)
Biochem J
, vol.325
, pp. 623-629
-
-
Bornemann, C.1
Jardine, M.A.2
Spies, H.S.C.3
Steenkamp, D.J.4
-
5
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, III, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream M-A, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry C.E. III10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.-A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
6
-
-
0032692928
-
Thiols in formaldehyde dissimilation and detoxification
-
Duine JA (1999) Thiols in formaldehyde dissimilation and detoxification. Biofactors 10:201-206
-
(1999)
Biofactors
, vol.10
, pp. 201-206
-
-
Duine, J.A.1
-
8
-
-
0025118967
-
Molecular and cellular aspects of thiol-disulfide exchange
-
Gilbert HF (1990) Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol 63:69-172
-
(1990)
Adv Enzymol Relat Areas Mol Biol
, vol.63
, pp. 69-172
-
-
Gilbert, H.F.1
-
9
-
-
0036173507
-
Synthesis of mycothiol, 1D-1-O-(2-[N-acetyl-L-cysteinyl]amino-2-deoxy-α-D-glucopyranosyl)-myo- inositol, principal low molecular mass thiol in the actinomycetes
-
Jardine MA, Spies HS, Nkambule CM, Gammon DW, Steenkamp DJ (2002) Synthesis of mycothiol, 1D-1-O-(2-[N-acetyl-L-cysteinyl]amino-2-deoxy-α-D-glucopyranosyl)-myo- inositol, principal low molecular mass thiol in the actinomycetes. Bioorg Med Chem 10:875-881
-
(2002)
Bioorg Med Chem
, vol.10
, pp. 875-881
-
-
Jardine, M.A.1
Spies, H.S.2
Nkambule, C.M.3
Gammon, D.W.4
Steenkamp, D.J.5
-
10
-
-
0030032199
-
A second molybdoprotein aldehyde dehydrogenase from Amycolatopsis methanolica NCIB 11946
-
Kim SW, Luykx DM, de Vries S, Duine JA (1996) A second molybdoprotein aldehyde dehydrogenase from Amycolatopsis methanolica NCIB 11946. Arch Biochem Biophys 325:1-7
-
(1996)
Arch Biochem Biophys
, vol.325
, pp. 1-7
-
-
Kim, S.W.1
Luykx, D.M.2
De Vries, S.3
Duine, J.A.4
-
11
-
-
0036401562
-
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes
-
DOI 10.1007/s00203-002-0462-y
-
Koledin T, Newton GL, Fahey RC (2002) Identification of the my-cothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol DOI 10.1007/s00203-002-0462-y
-
(2002)
Arch Microbiol
-
-
Koledin, T.1
Newton, G.L.2
Fahey, R.C.3
-
12
-
-
0034723345
-
Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of Inha inhibitor
-
Lei B, Wei CJ, Tu SC (2000) Action mechanism of antitubercular isoniazid. Activation by Mycobacterium tuberculosis KatG, isolation, and characterization of Inha inhibitor. J Biol Chem 275:2520-2526
-
(2000)
J Biol Chem
, vol.275
, pp. 2520-2526
-
-
Lei, B.1
Wei, C.J.2
Tu, S.C.3
-
13
-
-
0001945974
-
A brief history of glutathione and a survey of its metabolism and function
-
Dolphin D, Poulson R, Avramovic O (eds). Wiley, New York
-
Meister A (1989) A brief history of glutathione and a survey of its metabolism and function. In: Dolphin D, Poulson R, Avra-movic O (eds) Glutathione, Chemical, Biochemical, and Medical Aspects. Part A. Wiley, New York, pp 1-48
-
(1989)
Glutathione, Chemical, Biochemical, and Medical Aspects. Part A
, pp. 1-48
-
-
Meister, A.1
-
14
-
-
0030942708
-
Mycothiol, 1-O-(2′-[N-acetyl-L-cysteinyl]amido-2′-deoxy-α-D- glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase
-
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA (1997) Mycothiol, 1-O-(2′-[N-acetyl-L-cysteinyl]amido-2′-deoxy-α-D- glucopyranosyl)-D-myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase. FEBS Lett 409:221-222
-
(1997)
FEBS Lett
, vol.409
, pp. 221-222
-
-
Misset-Smits, M.1
Van Ophem, P.W.2
Sakuda, S.3
Duine, J.A.4
-
15
-
-
0029022647
-
Determination of biothiols by bromobimane labeling and high-performance liquid chromatography
-
Newton GL, Fahey RC (1995) Determination of biothiols by bromobimane labeling and high-performance liquid chromatography. Methods Enzymol 251:148-166
-
(1995)
Methods Enzymol
, vol.251
, pp. 148-166
-
-
Newton, G.L.1
Fahey, R.C.2
-
16
-
-
0027267127
-
Low molecular weight thiols in streptomycetes and their potential role as antioxidants
-
Newton GL, Fahey RC, Cohen G, Aharonowitz Y (1993) Low molecular weight thiols in streptomycetes and their potential role as antioxidants. J Bacteriol 175:2734-2742
-
(1993)
J Bacteriol
, vol.175
, pp. 2734-2742
-
-
Newton, G.L.1
Fahey, R.C.2
Cohen, G.3
Aharonowitz, Y.4
-
17
-
-
0029016701
-
The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol
-
Newton GL, Bewley CA, Dwyer TJ, Horn R, Aharonowitz Y, Co-hen G, Davies J, Faulkner DJ, Fahey RC (1995) The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol. Eur J Biochem 230:821-825
-
(1995)
Eur J Biochem
, vol.230
, pp. 821-825
-
-
Newton, G.L.1
Bewley, C.A.2
Dwyer, T.J.3
Horn, R.4
Aharonowitz, Y.5
Cohen, G.6
Davies, J.7
Faulkner, D.J.8
Fahey, R.C.9
-
18
-
-
9244225687
-
Distribution of thiols in microorganisms: Mycothiol is a major thiol in most actinomycetes
-
Newton GL, Arnold K, Price MS, Sherrill C, delCardayré SB, Aharonowitz Y, Cohen G, Davies J, Fahey RC, Davis C (1996) Distribution of thiols in microorganisms: Mycothiol is a major thiol in most actinomycetes. J Bacteriol 178:1990-1995
-
(1996)
J Bacteriol
, vol.178
, pp. 1990-1995
-
-
Newton, G.L.1
Arnold, K.2
Price, M.S.3
Sherrill, C.4
DelCardayré, S.B.5
Aharonowitz, Y.6
Cohen, G.7
Davies, J.8
Fahey, R.C.9
Davis, C.10
-
19
-
-
0033573949
-
Characterization of a Mycobacterium smegmatis mutant defective in 1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside and mycothiol biosynthesis
-
Newton GL, Unson M, Anderberg S, Aguilera JA, Oh NN, del-Cardayre S, Davies J, Av-Gay Y, Fahey RC (1999) Characterization of a Mycobacterium smegmatis mutant defective in 1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside and my-cothiol biosynthesis. Biochem Biophys Res Commun 255:239-244
-
(1999)
Biochem Biophys Res Commun
, vol.255
, pp. 239-244
-
-
Newton, G.L.1
Unson, M.2
Anderberg, S.3
Aguilera, J.A.4
Oh, N.N.5
Del-Cardayre, S.6
Davies, J.7
Av-Gay, Y.8
Fahey, R.C.9
-
20
-
-
0034460953
-
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis
-
Newton GL, Av-Gay Y, Fahey RC (2000a)N-Acetyl-1-D-myo-ino-sityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J Bacteriol 182:6958-6963
-
(2000)
J Bacteriol
, vol.182
, pp. 6958-6963
-
-
Newton, G.L.1
Av-Gay, Y.2
Fahey, R.C.3
-
21
-
-
0034609546
-
A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase
-
Newton GL, Av-Gay Y, Fahey RC (2000b) A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 35:10739-10746
-
(2000)
Biochemistry
, vol.35
, pp. 10739-10746
-
-
Newton, G.L.1
Av-Gay, Y.2
Fahey, R.C.3
-
22
-
-
0035902239
-
Novel bromotyrosine alkaloids: Inhibitors of mycothiol S-conjugate amidase
-
Nicholas GM, Newton GL, Fahey RC, Bewley CA (2001) Novel bromotyrosine alkaloids: Inhibitors of mycothiol S-conjugate amidase. Org Lett 3:1543-1545
-
(2001)
Org Lett
, vol.3
, pp. 1543-1545
-
-
Nicholas, G.M.1
Newton, G.L.2
Fahey, R.C.3
Bewley, C.A.4
-
23
-
-
0037009197
-
Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase
-
Nicholas GM, Eckman LL, Ray S, Hughes RO, Pfefferkorn JA, Barluenga S, Nicolaou KC, Bewley CA (2002a) Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett 12:2487-2490
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 2487-2490
-
-
Nicholas, G.M.1
Eckman, L.L.2
Ray, S.3
Hughes, R.O.4
Pfefferkorn, J.A.5
Barluenga, S.6
Nicolaou, K.C.7
Bewley, C.A.8
-
24
-
-
0037051620
-
Total synthesis and proof of structure of mycothiol bimane
-
Nicholas GM, Kovac P, Bewley CA (2002b) Total synthesis and proof of structure of mycothiol bimane. J Amer Chem Soc 124:3492-3493
-
(2002)
J Amer Chem Soc
, vol.124
, pp. 3492-3493
-
-
Nicholas, G.M.1
Kovac, P.2
Bewley, C.A.3
-
25
-
-
0030885783
-
Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases - Primary structure, conformational modelling and functional correlations
-
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H (1997) Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases - Primary structure, conformational modelling and functional correlations. Eur J Biochem 248:282-289
-
(1997)
Eur J Biochem
, vol.248
, pp. 282-289
-
-
Norin, A.1
Van Ophem, P.W.2
Piersma, S.R.3
Persson, B.4
Duine, J.A.5
Jornvall, H.6
-
26
-
-
0032190375
-
ωR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2)
-
Paget MS, Kang JG, Roe JH, Buttner MJ (1998) ωR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2). EMBO J 17:5776-5782
-
(1998)
EMBO J
, vol.17
, pp. 5776-5782
-
-
Paget, M.S.1
Kang, J.G.2
Roe, J.H.3
Buttner, M.J.4
-
28
-
-
0032508871
-
Synthesis of des-myo-inositol mycothiol and demonstration of a mycobacterial specific reductase activity
-
Patel M, Blanchard J (1998) Synthesis of des-myo-inositol mycothiol and demonstration of a mycobacterial specific reductase activity. J Amer Chem Soc 120:11538-11539
-
(1998)
J Amer Chem Soc
, vol.120
, pp. 11538-11539
-
-
Patel, M.1
Blanchard, J.2
-
29
-
-
0033533411
-
Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase
-
Patel MP, Blanchard JS (1999) Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. Biochemistry 38:11827-11833
-
(1999)
Biochemistry
, vol.38
, pp. 11827-11833
-
-
Patel, M.P.1
Blanchard, J.S.2
-
30
-
-
0035339865
-
Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects
-
Patel MP, Blanchard JS (2001)Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects. Biochemistry 40:3119-3126
-
(2001)
Biochemistry
, vol.40
, pp. 3119-3126
-
-
Patel, M.P.1
Blanchard, J.S.2
-
31
-
-
0029084746
-
Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11
-
Peschke U, Schmidt H, Zhang HZ, Piepersberg W (1995) Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. Mol Microbiol 16:1137-1156
-
(1995)
Mol Microbiol
, vol.16
, pp. 1137-1156
-
-
Peschke, U.1
Schmidt, H.2
Zhang, H.Z.3
Piepersberg, W.4
-
32
-
-
0036840388
-
Mycothiol deficient mutants in Mycobacterium smegmatis are hypersensitive to alkylating agents, free radicals and antibiotics
-
in press
-
Rawat M, Newton GL, Ko M, Martinez GJ, Fahey RC, Av-Gay Y (2002) Mycothiol deficient mutants in Mycobacterium smegmatis are hypersensitive to alkylating agents, free radicals and antibiotics. Antimicrob Agents Chemother (in press)
-
(2002)
Antimicrob Agents Chemother
-
-
Rawat, M.1
Newton, G.L.2
Ko, M.3
Martinez, G.J.4
Fahey, R.C.5
Av-Gay, Y.6
-
33
-
-
0032472224
-
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis
-
Rozwarski DA, Grant GA, Barton DH, Jacobs WR, Jr., Sacchettini JC (1998) Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. Science 279:98-102
-
(1998)
Science
, vol.279
, pp. 98-102
-
-
Rozwarski, D.A.1
Grant, G.A.2
Barton, D.H.3
Jacobs W.R., Jr.4
Sacchettini, J.C.5
-
34
-
-
0028469774
-
Structure of a novel disulfide of 2-(N-acetylcysteinyl)amido-2-deoxy-α-D-glucopyranosyl-myo-inositol produced by Streptomyces sp
-
Sakuda S, Zhou Z-Y, Yamada Y (1994) Structure of a novel disulfide of 2-(N-acetylcysteinyl)amido-2-deoxy-α-D-glucopyranosyl-myo-inositol produced byStreptomyces sp. Biosci Biotech Biochem 58:1347-1348
-
(1994)
Biosci Biotech Biochem
, vol.58
, pp. 1347-1348
-
-
Sakuda, S.1
Zhou, Z.-Y.2
Yamada, Y.3
-
35
-
-
0037018946
-
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-α-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases
-
Sareen D, Steffek M, Newton GL, Fahey RC (2002) ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-α-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry 41:8885-6890
-
(2002)
Biochemistry
, vol.41
, pp. 8885-6890
-
-
Sareen, D.1
Steffek, M.2
Newton, G.L.3
Fahey, R.C.4
-
36
-
-
0034084624
-
The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis
-
Slayden RA, Barry CE, 3rd (2000) The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis. Microbes Infect 2:659-669
-
(2000)
Microbes Infect
, vol.2
, pp. 659-669
-
-
Slayden, R.A.1
Barry C.E. III2
-
37
-
-
0027990965
-
Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis
-
Spies HS, Steenkamp DJ (1994) Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis. Eur J Biochem 224:203-213
-
(1994)
Eur J Biochem
, vol.224
, pp. 203-213
-
-
Spies, H.S.1
Steenkamp, D.J.2
-
38
-
-
0031839173
-
An immunoassay for the detection and quantitative determination of mycothiol
-
Unson MD, Newton GL, Davis C, Fahey RC (1998) An immunoassay for the detection and quantitative determination of mycothiol. J Immunol Methods 214:29-39
-
(1998)
J Immunol Methods
, vol.214
, pp. 29-39
-
-
Unson, M.D.1
Newton, G.L.2
Davis, C.3
Fahey, R.C.4
-
39
-
-
0033042505
-
Improved methods for the immunoassay of mycothiol
-
Unson MD, Newton GL, Arnold KF, Davis CE, Fahey RC (1999) Improved methods for the immunoassay of mycothiol. J Clin Microbiol 37:2153-2157
-
(1999)
J Clin Microbiol
, vol.37
, pp. 2153-2157
-
-
Unson, M.D.1
Newton, G.L.2
Arnold, K.F.3
Davis, C.E.4
Fahey, R.C.5
-
40
-
-
0000221995
-
Glutathione-dependent oxidoreductases: Formaldehyde dehydrogenase
-
Dolphin D, Poulson R, Avramovic O (eds). Wiley, New York
-
Uotila L, Koivusalo M (1989) Glutathione-dependent oxidoreductases: Formaldehyde dehydrogenase. In: Dolphin D, Poulson R, Avramovic O (eds) Glutathione: Chemical, Biochemical, and Medical Aspects. Part A. Wiley, New York, pp 517-551
-
(1989)
Glutathione: Chemical, Biochemical, and Medical Aspects. Part A
, pp. 517-551
-
-
Uotila, L.1
Koivusalo, M.2
-
41
-
-
0011442675
-
Chemistry and properties of glutathione
-
Colowick S, Schwartz DR, Lazarow A, Stadtman E, Racker E, Waelsch H (eds). Academic, New York
-
Wieland T (1954) Chemistry and properties of glutathione. In: Colowick S, Schwartz DR, Lazarow A, Stadtman E, Racker E, Waelsch H (eds) Glutathione. Academic, New York, pp 45-59
-
(1954)
Glutathione
, pp. 45-59
-
-
Wieland, T.1
-
42
-
-
0033607188
-
Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
-
Wilson M, DeRisi J, Kristensen HH, Imboden P, Rane S, Brown PO, Schoolnik GK (1999) Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization. Proc Natl Acad Sci USA 96:12833-12838
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12833-12838
-
-
Wilson, M.1
DeRisi, J.2
Kristensen, H.H.3
Imboden, P.4
Rane, S.5
Brown, P.O.6
Schoolnik, G.K.7
|