Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity

ACS Chemical Biology

Volumn 11, Issue 1, 2016, Pages 121-131

  Gower, Carrie M ^a   Thomas, Jason R ^b   Harrington, Edmund ^b   Murphy, Jason ^b   Chang, Matthew E K ^a   Cornella Taracido, Ivan ^b   Jain, Rishi K ^b   Schirle, Markus ^b   Maly, Dustin J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; BCR ABL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOTRANSFERASE INHIBITOR; MAPK1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING SITE; CELL LYSATE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; K562 CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEOMICS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; HUMAN; IC50; K-562 CELL LINE; METABOLISM; MOLECULAR MODEL; PHOSPHORYLATION;

BINDING SITES; ENZYME ACTIVATION; FUSION PROTEINS, BCR-ABL; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEOMICS;

EID: 84955075907     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00847     Document Type: Article

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