-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. The protein kinase complement of the human genome. Science 2002, 298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
55049140325
-
Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care
-
Kruse U., Bantscheff M., Drewes G., Hopf C. Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care. Mol Cell Proteomics 2008, 7:1887-1901.
-
(2008)
Mol Cell Proteomics
, vol.7
, pp. 1887-1901
-
-
Kruse, U.1
Bantscheff, M.2
Drewes, G.3
Hopf, C.4
-
3
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm S.M., Adnane L., Newell P., Villanueva A., Llovet J.M., Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008, 7:3129-3140.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
4
-
-
84871312669
-
A public-private partnership to unlock the untargeted kinome
-
Knapp S., Arruda P., Blagg J., Burley S., Drewry D.H., Edwards A., et al. A public-private partnership to unlock the untargeted kinome. Nat Chem Biol 2013, 9:3-6.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 3-6
-
-
Knapp, S.1
Arruda, P.2
Blagg, J.3
Burley, S.4
Drewry, D.H.5
Edwards, A.6
-
5
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman M.W., Herrgard S., Treiber D.K., Gallant P., Atteridge C.E., Campbell B.T., et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008, 26:127-132.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
-
6
-
-
84856392676
-
Mass spectrometry-based proteomics in preclinical drug discovery
-
Schirle M., Bantscheff M., Kuster B. Mass spectrometry-based proteomics in preclinical drug discovery. Chem Biol 2012, 19:72-84.
-
(2012)
Chem Biol
, vol.19
, pp. 72-84
-
-
Schirle, M.1
Bantscheff, M.2
Kuster, B.3
-
7
-
-
84866388559
-
Mass spectrometry approaches to monitor protein-drug interactions
-
Zinn N., Hopf C., Drewes G., Bantscheff M. Mass spectrometry approaches to monitor protein-drug interactions. Methods 2012, 57:430-440.
-
(2012)
Methods
, vol.57
, pp. 430-440
-
-
Zinn, N.1
Hopf, C.2
Drewes, G.3
Bantscheff, M.4
-
8
-
-
84857911138
-
Chemoproteomic approaches to drug target identification and drug profiling
-
Bantscheff M., Drewes G. Chemoproteomic approaches to drug target identification and drug profiling. Bioorg Med Chem 2012, 20:1973-1978.
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 1973-1978
-
-
Bantscheff, M.1
Drewes, G.2
-
9
-
-
77954464041
-
Proteomics: a pragmatic perspective
-
Mallick P., Kuster B. Proteomics: a pragmatic perspective. Nat Biotechnol 2010, 28:695-709.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 695-709
-
-
Mallick, P.1
Kuster, B.2
-
10
-
-
34748916981
-
Quantitative mass spectrometry in proteomics: a critical review
-
Bantscheff M., Schirle M., Sweetman G., Rick J., Kuster B. Quantitative mass spectrometry in proteomics: a critical review. Anal Bioanal Chem 2007, 389:1017-1031.
-
(2007)
Anal Bioanal Chem
, vol.389
, pp. 1017-1031
-
-
Bantscheff, M.1
Schirle, M.2
Sweetman, G.3
Rick, J.4
Kuster, B.5
-
11
-
-
84865604070
-
Quantitative mass spectrometry in proteomics
-
Bantscheff M., Kuster B. Quantitative mass spectrometry in proteomics. Anal Bioanal Chem 2012, 404:937-938.
-
(2012)
Anal Bioanal Chem
, vol.404
, pp. 937-938
-
-
Bantscheff, M.1
Kuster, B.2
-
12
-
-
80555144285
-
Kinase inhibitor profiling using chemoproteomics
-
Schirle M., Petrella E.C., Brittain S.M., Schwalb D., Harrington E., Cornella-Taracido I., et al. Kinase inhibitor profiling using chemoproteomics. Methods Mol Biol 2012, 795:161-177.
-
(2012)
Methods Mol Biol
, vol.795
, pp. 161-177
-
-
Schirle, M.1
Petrella, E.C.2
Brittain, S.M.3
Schwalb, D.4
Harrington, E.5
Cornella-Taracido, I.6
-
13
-
-
9144219693
-
An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
-
Godl K., Wissing J., Kurtenbach A., Habenberger P., Blencke S., Gutbrod H., et al. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc Natl Acad Sci U S A 2003, 100:15434-15439.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15434-15439
-
-
Godl, K.1
Wissing, J.2
Kurtenbach, A.3
Habenberger, P.4
Blencke, S.5
Gutbrod, H.6
-
14
-
-
0036892305
-
Discovery of novel targets of quinoline drugs in the human purine binding proteome
-
Graves P.R., Kwiek J.J., Fadden P., Ray R., Hardeman K., Coley A.M., et al. Discovery of novel targets of quinoline drugs in the human purine binding proteome. Mol Pharmacol 2002, 62:1364-1372.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1364-1372
-
-
Graves, P.R.1
Kwiek, J.J.2
Fadden, P.3
Ray, R.4
Hardeman, K.5
Coley, A.M.6
-
15
-
-
33846248354
-
Functional interrogation of the kinome using nucleotide acyl phosphates
-
Patricelli M.P., Szardenings A.K., Liyanage M., Nomanbhoy T.K., Wu M., Weissig H., et al. Functional interrogation of the kinome using nucleotide acyl phosphates. Biochemistry 2007, 46:350-358.
-
(2007)
Biochemistry
, vol.46
, pp. 350-358
-
-
Patricelli, M.P.1
Szardenings, A.K.2
Liyanage, M.3
Nomanbhoy, T.K.4
Wu, M.5
Weissig, H.6
-
16
-
-
34948875686
-
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
-
Bantscheff M., Eberhard D., Abraham Y., Bastuck S., Boesche M., Hobson S., et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol 2007, 25:1035-1044.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1035-1044
-
-
Bantscheff, M.1
Eberhard, D.2
Abraham, Y.3
Bastuck, S.4
Boesche, M.5
Hobson, S.6
-
17
-
-
77949848665
-
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
-
Li J., Rix U., Fang B., Bai Y., Edwards A., Colinge J., et al. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol 2010, 6:291-299.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 291-299
-
-
Li, J.1
Rix, U.2
Fang, B.3
Bai, Y.4
Edwards, A.5
Colinge, J.6
-
18
-
-
83055168499
-
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer
-
Wu Z., Doondeea J.B., Gholami A.M., Janning M.C., Lemeer S., Kramer K., et al. Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. Mol Cell Proteomics 2011, 10(M111):011635.
-
(2011)
Mol Cell Proteomics
, vol.10
, Issue.M111
, pp. 011635
-
-
Wu, Z.1
Doondeea, J.B.2
Gholami, A.M.3
Janning, M.C.4
Lemeer, S.5
Kramer, K.6
-
19
-
-
84875914218
-
Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity
-
Lemeer S., Zorgiebel C., Ruprecht B., Kohl K., Kuster B. Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity. J Proteome Res 2013, 12(4):1723-1731.
-
(2013)
J Proteome Res
, vol.12
, Issue.4
, pp. 1723-1731
-
-
Lemeer, S.1
Zorgiebel, C.2
Ruprecht, B.3
Kohl, K.4
Kuster, B.5
-
20
-
-
70349624519
-
Proteomics strategy for quantitative protein interaction profiling in cell extracts
-
Sharma K., Weber C., Bairlein M., Greff Z., Keri G., Cox J., et al. Proteomics strategy for quantitative protein interaction profiling in cell extracts. Nat Methods 2009, 6:741-744.
-
(2009)
Nat Methods
, vol.6
, pp. 741-744
-
-
Sharma, K.1
Weber, C.2
Bairlein, M.3
Greff, Z.4
Keri, G.5
Cox, J.6
-
21
-
-
84881159771
-
Characterization of a chemical affinity probe targeting AKT kinases
-
Pachl F., Plattner P., Ruprecht B., Médard G., Sewald N., Kuster B. Characterization of a chemical affinity probe targeting AKT kinases. J Proteome Res 2013, 12(8):3792-3800.
-
(2013)
J Proteome Res
, vol.12
, Issue.8
, pp. 3792-3800
-
-
Pachl, F.1
Plattner, P.2
Ruprecht, B.3
Médard, G.4
Sewald, N.5
Kuster, B.6
-
22
-
-
84879907745
-
Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling
-
Zhang L., Holmes I.P., Hochgrafe F., Walker S.R., Ali N.A., Humphrey E.S., et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res 2013, 12:3104-3116.
-
(2013)
J Proteome Res
, vol.12
, pp. 3104-3116
-
-
Zhang, L.1
Holmes, I.P.2
Hochgrafe, F.3
Walker, S.R.4
Ali, N.A.5
Humphrey, E.S.6
-
23
-
-
84859415553
-
Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
-
Brooks A.N., Kilgour E., Smith P.D. Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res 2012, 18:1855-1862.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1855-1862
-
-
Brooks, A.N.1
Kilgour, E.2
Smith, P.D.3
-
25
-
-
84881159771
-
Characterization of a chemical affinity probe targeting AKT kinases
-
Pachl F., Plattner P., Ruprecht B., Médard G., Sewald N., Kuster B. Characterization of a chemical affinity probe targeting AKT kinases. J Proteome Res 2013, 12:3792-3800.
-
(2013)
J Proteome Res
, vol.12
, pp. 3792-3800
-
-
Pachl, F.1
Plattner, P.2
Ruprecht, B.3
Médard, G.4
Sewald, N.5
Kuster, B.6
-
26
-
-
84862323158
-
Systematic identification of the HSP90 candidate regulated proteome
-
Wu Z., Moghaddas Gholami A., Kuster B. Systematic identification of the HSP90 candidate regulated proteome. Mol Cell Proteomics 2012, 11(M111):016675.
-
(2012)
Mol Cell Proteomics
, vol.11
, Issue.M111
, pp. 016675
-
-
Wu, Z.1
Moghaddas Gholami, A.2
Kuster, B.3
-
27
-
-
29244448703
-
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
-
Olsen J.V., de Godoy L.M., Li G., Macek B., Mortensen P., Pesch R., et al. Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics 2005, 4:2010-2021.
-
(2005)
Mol Cell Proteomics
, vol.4
, pp. 2010-2021
-
-
Olsen, J.V.1
de Godoy, L.M.2
Li, G.3
Macek, B.4
Mortensen, P.5
Pesch, R.6
-
28
-
-
0032531929
-
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
-
Mohammadi M., Froum S., Hamby J.M., Schroeder M.C., Panek R.L., Lu G.H., et al. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J 1998, 17:5896-5904.
-
(1998)
EMBO J
, vol.17
, pp. 5896-5904
-
-
Mohammadi, M.1
Froum, S.2
Hamby, J.M.3
Schroeder, M.C.4
Panek, R.L.5
Lu, G.H.6
-
29
-
-
80051685673
-
FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo
-
Sharpe R., Pearson A., Herrera-Abreu M.T., Johnson D., Mackay A., Welti J.C., et al. FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin Cancer Res 2011, 17:5275-5286.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5275-5286
-
-
Sharpe, R.1
Pearson, A.2
Herrera-Abreu, M.T.3
Johnson, D.4
Mackay, A.5
Welti, J.C.6
-
30
-
-
72249093331
-
The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo
-
Pardo O.E., Latigo J., Jeffery R.E., Nye E., Poulsom R., Spencer-Dene B., et al. The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res 2009, 69:8645-8651.
-
(2009)
Cancer Res
, vol.69
, pp. 8645-8651
-
-
Pardo, O.E.1
Latigo, J.2
Jeffery, R.E.3
Nye, E.4
Poulsom, R.5
Spencer-Dene, B.6
-
31
-
-
0034736093
-
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases
-
Barvian M., Boschelli D.H., Cossrow J., Dobrusin E., Fattaey A., Fritsch A., et al. Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem 2000, 43:4606-4616.
-
(2000)
J Med Chem
, vol.43
, pp. 4606-4616
-
-
Barvian, M.1
Boschelli, D.H.2
Cossrow, J.3
Dobrusin, E.4
Fattaey, A.5
Fritsch, A.6
-
32
-
-
80755125565
-
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
-
Anastassiadis T., Deacon S.W., Devarajan K., Ma H., Peterson J.R. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol 2011, 29:1039-1045.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 1039-1045
-
-
Anastassiadis, T.1
Deacon, S.W.2
Devarajan, K.3
Ma, H.4
Peterson, J.R.5
-
33
-
-
23044510618
-
Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling
-
Godl K., Gruss O.J., Eickhoff J., Wissing J., Blencke S., Weber M., et al. Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling. Cancer Res 2005, 65:6919-6926.
-
(2005)
Cancer Res
, vol.65
, pp. 6919-6926
-
-
Godl, K.1
Gruss, O.J.2
Eickhoff, J.3
Wissing, J.4
Blencke, S.5
Weber, M.6
-
34
-
-
19244370071
-
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
-
Sun L., Tran N., Liang C., Tang F., Rice A., Schreck R., et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem 1999, 42:5120-5130.
-
(1999)
J Med Chem
, vol.42
, pp. 5120-5130
-
-
Sun, L.1
Tran, N.2
Liang, C.3
Tang, F.4
Rice, A.5
Schreck, R.6
-
35
-
-
11244349115
-
Vascular endothelial growth factor (VEGF) inhibition by small molecules
-
Ahmed S.I., Thomas A.L., Steward W.P. Vascular endothelial growth factor (VEGF) inhibition by small molecules. J Chemother 2004, 16(Suppl. 4):59-63.
-
(2004)
J Chemother
, vol.16
, Issue.SUPPL. 4
, pp. 59-63
-
-
Ahmed, S.I.1
Thomas, A.L.2
Steward, W.P.3
-
36
-
-
33749544080
-
An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
-
Kim D.W., Jo Y.S., Jung H.S., Chung H.K., Song J.H., Park K.C., et al. An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 2006, 91:4070-4076.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4070-4076
-
-
Kim, D.W.1
Jo, Y.S.2
Jung, H.S.3
Chung, H.K.4
Song, J.H.5
Park, K.C.6
-
37
-
-
77953022206
-
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
-
Sawamiphak S., Seidel S., Essmann C.L., Wilkinson G.A., Pitulescu M.E., Acker T., et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 2010, 465:487-491.
-
(2010)
Nature
, vol.465
, pp. 487-491
-
-
Sawamiphak, S.1
Seidel, S.2
Essmann, C.L.3
Wilkinson, G.A.4
Pitulescu, M.E.5
Acker, T.6
-
38
-
-
77953029002
-
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
-
Wang Y., Nakayama M., Pitulescu M.E., Schmidt T.S., Bochenek M.L., Sakakibara A., et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 2010, 465:483-486.
-
(2010)
Nature
, vol.465
, pp. 483-486
-
-
Wang, Y.1
Nakayama, M.2
Pitulescu, M.E.3
Schmidt, T.S.4
Bochenek, M.L.5
Sakakibara, A.6
-
39
-
-
80052534056
-
Functional dissection of the TBK1 molecular network
-
Goncalves A., Burckstummer T., Dixit E., Scheicher R., Gorna M.W., Karayel E., et al. Functional dissection of the TBK1 molecular network. PLoS One 2011, 6:e23971.
-
(2011)
PLoS One
, vol.6
-
-
Goncalves, A.1
Burckstummer, T.2
Dixit, E.3
Scheicher, R.4
Gorna, M.W.5
Karayel, E.6
-
40
-
-
0037020147
-
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
-
Chariot A., Leonardi A., Muller J., Bonif M., Brown K., Siebenlist U. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem 2002, 277:37029-37036.
-
(2002)
J Biol Chem
, vol.277
, pp. 37029-37036
-
-
Chariot, A.1
Leonardi, A.2
Muller, J.3
Bonif, M.4
Brown, K.5
Siebenlist, U.6
|