A chemical genetic method for generating bivalent inhibitors of protein kinases

Journal of the American Chemical Society

Volumn 131, Issue 19, 2009, Pages 6686-6688

  Hill, Zachary B ^a   Gayani, B ^a   Perera, K ^a   Maly, Dustin J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; LABELS; MOLECULES; TARGETS;

ATP-BINDING; BINDING DOMAIN; BIVALENT LIGANDS; CHEMOSELECTIVE; GENETIC METHODS; KEY FEATURE; KINASE INHIBITORS; KINASE TARGETS; MODULAR COMPONENTS; PEPTIDIC LIGANDS; POTENT INHIBITOR; PROTEIN KINASE; PROTEIN LABELING; SMALL MOLECULES; TWO-COMPONENT; TYROSINE KINASE;

LIGANDS;

HISTIDINE; PROTEIN KINASE INHIBITOR; 8-OXO-O(6)-BENZYLGUANINE; GUANINE; LIGAND; PROTEIN; PROTEIN KINASE;

ARTICLE; CHEMICAL BINDING; ENZYME INHIBITION; IC 50; PROTEIN DOMAIN; PROTEIN MOTIF; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; GENETICS; SRC HOMOLOGY DOMAIN; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; GUANINE; LIGANDS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEINS; SRC HOMOLOGY DOMAINS;

EID: 67650553064     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900871y     Document Type: Article

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