Tuning a three-component reaction for trapping kinase substrate complexes

Journal of the American Chemical Society

Volumn 130, Issue 51, 2008, Pages 17568-17574

  Statsuk, Alexander V ^a   Maly, Dustin J ^a   Seeliger, Markus A ^b   Fabian, Miles A ^c   Biggs III, William H ^c   Lockhart, David J ^c   Zarrinkar, Patrick P ^c   Kuriyan, John ^b   Shokat, Kevan M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Ambit Biosciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CELLULAR PROTEINS; CROSSLINKER; IN-CELL; KINASE COMPLEX; KINASE SUBSTRATES; NONCOVALENT; O-PHTHALDIALDEHYDE; PROTEIN KINASE; PROTEIN KINASE INHIBITORS; SIDE REACTIONS; STRUCTURAL MODIFICATIONS; THREE COMPONENT REACTIONS; THREE-COMPONENT;

ALDEHYDES; AMINO ACIDS; CELL MEMBRANES; CROSSLINKING; PROTEINS; THIOPHENE;

SUBSTRATES;

ADENOSINE; CELL PROTEIN; CYSTEINE; ISOINDOLE DERIVATIVE; PHTHALALDEHYDE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; THIOPHENE 2,3 DICARBOXALDEHYDE; UNCLASSIFIED DRUG; CROSS LINKING REAGENT; FLUORESCENT DYE; LYSINE; PEPTIDE; PHOSPHOTRANSFERASE; PROTEIN; THIOPHENE DERIVATIVE;

ARTICLE; CELL LYSATE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CROSS LINKING; EMBRYO; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; THREE COMPONENT REACTION; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; HELA CELL LINE; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

ADENOSINE; CROSS-LINKING REAGENTS; CYSTEINE; FLUORESCENT DYES; HELA CELLS; HUMANS; LYSINE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PEPTIDES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; THIOPHENES;

EID: 69049087175     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja807066f     Document Type: Article

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