Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages

  Kummer, Lutz ^a   Parizek, Petra ^a   Rube, Peter ^b   Millgramm, Bastian ^b   Prinz, Anke ^b   Mittl, Peer R E ^a   Kaufholz, Melanie ^c   Zimmermann, Bastian ^c   Herberg, Friedrich W ^b   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF KASSEL   (Germany)

^c Biaffin GmbH and CoKG   (Germany)

Author keywords

Intrabodies; X ray crystallography

Indexed keywords

ANKYRIN; GREEN FLUORESCENT PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STRAIN COS7; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; ENERGY TRANSFER; INTRACELLULAR SIGNALING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RENILLA;

ANIMALS; ANKYRIN REPEAT; COMPUTATIONAL BIOLOGY; COS CELLS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HEK293 CELLS; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RIBOSOMES;

EID: 84865302440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205399109     Document Type: Article

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