-
1
-
-
10944258108
-
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways
-
Aeder SE, Martin PM, Soh J-W, Hussaini IM (2004). PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. Oncogene 23, 9062-9069.
-
(2004)
Oncogene
, vol.23
, pp. 9062-9069
-
-
Aeder, S.E.1
Martin, P.M.2
Soh, J.-W.3
Hussaini, I.M.4
-
2
-
-
1842843536
-
MHC class II compartments in human dendritic cells undergo profound structural changes upon activation
-
Barois N, de Saint-Vis B, Lebecque S, Geuze HJ, Kleijmeer MJ (2002). MHC class II compartments in human dendritic cells undergo profound structural changes upon activation. Traffic 3, 894-905.
-
(2002)
Traffic
, vol.3
, pp. 894-905
-
-
Barois, N.1
De Saint-Vis, B.2
Lebecque, S.3
Geuze, H.J.4
Kleijmeer, M.J.5
-
3
-
-
84866431363
-
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
-
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM (2012). Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208.
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
4
-
-
84857869690
-
TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages
-
Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G, Samavati L (2012). TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. J Immunol 188, 2847-2857.
-
(2012)
J Immunol
, vol.188
, pp. 2847-2857
-
-
Bauerfeld, C.P.1
Rastogi, R.2
Pirockinaite, G.3
Lee, I.4
Hüttemann, M.5
Monks, B.6
Birnbaum, M.J.7
Franchi, L.8
Nuñez, G.9
Samavati, L.10
-
5
-
-
0027207242
-
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of i kappa B alpha: A mechanism for NF-kappa B activation
-
Beg AA, Finco TS, Nantermet P V, Baldwin AS (1993). Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 13, 3301-3310.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3301-3310
-
-
Beg, A.A.1
Finco, T.S.2
Nantermet, P.V.3
Baldwin, A.S.4
-
6
-
-
0032560796
-
Akt activation by growth factors is a multiple-step process: The role of the PH domain
-
Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P (1998). Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17, 313-325.
-
(1998)
Oncogene
, vol.17
, pp. 313-325
-
-
Bellacosa, A.1
Chan, T.O.2
Ahmed, N.N.3
Datta, K.4
Malstrom, S.5
Stokoe, D.6
McCormick, F.7
Feng, J.8
Tsichlis, P.9
-
7
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
Beugnet A, Tee AR, Taylor PM, Proud CG (2003). Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J 372, 555-566.
-
(2003)
Biochem J
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
8
-
-
0141889165
-
T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner
-
Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H (2003). T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J Immunol 171, 4081-4088.
-
(2003)
J Immunol
, vol.171
, pp. 4081-4088
-
-
Boes, M.1
Bertho, N.2
Cerny, J.3
Op Den Brouw, M.4
Kirchhausen, T.5
Ploegh, H.6
-
9
-
-
0037194784
-
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
-
Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL (2002). T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418, 983-988.
-
(2002)
Nature
, vol.418
, pp. 983-988
-
-
Boes, M.1
Cerny, J.2
Massol, R.3
Op Den Brouw, M.4
Kirchhausen, T.5
Chen, J.6
Ploegh, H.L.7
-
10
-
-
0025597939
-
The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments
-
Burkhardt JK, Hester S, Lapham CK, Argon Y (1990). The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. J Cell Biol 111, 2327-2340.
-
(1990)
J Cell Biol
, vol.111
, pp. 2327-2340
-
-
Burkhardt, J.K.1
Hester, S.2
Lapham, C.K.3
Argon, Y.4
-
11
-
-
0037454946
-
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
-
Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J (2003). Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 197, 263-268.
-
(2003)
J Exp Med
, vol.197
, pp. 263-268
-
-
Burns, K.1
Janssens, S.2
Brissoni, B.3
Olivos, N.4
Beyaert, R.5
Tschopp, J.6
-
12
-
-
0035865135
-
Rab-interacting lysosomal protein (RILP): The Rab7 effector required for transport to lysosomes
-
Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (2001). Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J 20, 683-693.
-
(2001)
EMBO J
, vol.20
, pp. 683-693
-
-
Cantalupo, G.1
Alifano, P.2
Roberti, V.3
Bruni, C.B.4
Bucci, C.5
-
13
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC (2002). The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
14
-
-
0037194733
-
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
-
Chow A, Toomre D, Garrett W, Mellman I (2002). Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 418, 988-994.
-
(2002)
Nature
, vol.418
, pp. 988-994
-
-
Chow, A.1
Toomre, D.2
Garrett, W.3
Mellman, I.4
-
15
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta SR, Brunet A, Greenberg ME (1999). Cellular survival: a play in three Akts. Genes Dev 13, 2905-2927.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
16
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
-
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT (2003). LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 198, 1043-1055.
-
(2003)
J Exp Med
, vol.198
, pp. 1043-1055
-
-
Fitzgerald, K.A.1
Rowe, D.C.2
Barnes, B.J.3
Caffrey, D.R.4
Visintin, A.5
Latz, E.6
Monks, B.7
Pitha, P.M.8
Golenbock, D.T.9
-
17
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ (2008). AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30, 214-226.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
18
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA (2012). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13, 251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
19
-
-
0042691817
-
Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: Role of Rab7 and RILP
-
Harrison RE, Bucci C, Vieira O V, Schroer TA, Grinstein S (2003). Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol Cell Biol 23, 6494-6506.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6494-6506
-
-
Harrison, R.E.1
Bucci, C.2
Vieira, O.V.3
Schroer, T.A.4
Grinstein, S.5
-
20
-
-
84875185944
-
Development of a sensitive phospho-p70 S6 kinase ELISA to quantify mTOR proliferation signal inhibition
-
Hartmann B, He X, Keller F, Fischereder M, Guba M, Schmid H (2013). Development of a sensitive phospho-p70 S6 kinase ELISA to quantify mTOR proliferation signal inhibition. Ther Drug Monit 35, 233-239.
-
(2013)
Ther Drug Monit
, vol.35
, pp. 233-239
-
-
Hartmann, B.1
He, X.2
Keller, F.3
Fischereder, M.4
Guba, M.5
Schmid, H.6
-
21
-
-
0024523485
-
Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH
-
Heuser J (1989). Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH. J Cell Biol 108, 855-864.
-
(1989)
J Cell Biol
, vol.108
, pp. 855-864
-
-
Heuser, J.1
-
22
-
-
33644508366
-
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
-
Husebye H, Halaas Ø, Stenmark H, Tunheim G, Sandanger Ø, Bogen B, Brech A, Latz E, Espevik T (2006). Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J 25, 683-692.
-
(2006)
EMBO J
, vol.25
, pp. 683-692
-
-
Husebye, H.1
Halaas, Ø.2
Stenmark, H.3
Tunheim, G.4
Sandanger, Ø.5
Bogen, B.6
Brech, A.7
Latz, E.8
Espevik, T.9
-
23
-
-
0026481133
-
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
-
Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM (1992). Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176, 1693-1702.
-
(1992)
J Exp Med
, vol.176
, pp. 1693-1702
-
-
Inaba, K.1
Inaba, M.2
Romani, N.3
Aya, H.4
Deguchi, M.5
Ikehara, S.6
Muramatsu, S.7
Steinman, R.M.8
-
24
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL (2003a). Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17, 1829-1834.
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
25
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan K-L (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-657.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
26
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan K-L (2003b). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
27
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase a in vitro
-
Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K (1999). Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase a in vitro. J Biol Chem 274, 34493-34498.
-
(1999)
J Biol Chem
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
28
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN (2004). Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6, 1122-1128.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Rüegg, M.A.5
Hall, A.6
Hall, M.N.7
-
29
-
-
0035975946
-
The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dyneindynactin motors
-
Jordens I, Fernandez-Borja M, Marsman M, Dusseljee S, Janssen L, Calafat J, Janssen H, Wubbolts R, Neefjes J (2001). The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dyneindynactin motors. Curr Biol 11, 1680-1685.
-
(2001)
Curr Biol
, vol.11
, pp. 1680-1685
-
-
Jordens, I.1
Fernandez-Borja, M.2
Marsman, M.3
Dusseljee, S.4
Janssen, L.5
Calafat, J.6
Janssen, H.7
Wubbolts, R.8
Neefjes, J.9
-
30
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999). Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122.
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
31
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
Kawai T, Takeuchi O, Fujita T, Inoue J, Mühlradt PF, Sato S, Hoshino K, Akira S (2001). Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167, 5887-5894.
-
(2001)
J Immunol
, vol.167
, pp. 5887-5894
-
-
Kawai, T.1
Takeuchi, O.2
Fujita, T.3
Inoue, J.4
Mühlradt, P.F.5
Sato, S.6
Hoshino, K.7
Akira, S.8
-
32
-
-
59349105233
-
Monitoring autophagy in mammalian cultured cells through the dynamics of LC3
-
Kimura S, Fujita N, Noda T, Yoshimori T (2009). Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol 452, 1-12.
-
(2009)
Methods Enzymol
, vol.452
, pp. 1-12
-
-
Kimura, S.1
Fujita, N.2
Noda, T.3
Yoshimori, T.4
-
33
-
-
84889071052
-
MTOR regulates phagosome and entotic vacuole fission
-
Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M (2013). mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell 24, 3736-3745.
-
(2013)
Mol Biol Cell
, vol.24
, pp. 3736-3745
-
-
Krajcovic, M.1
Krishna, S.2
Akkari, L.3
Joyce, J.A.4
Overholtzer, M.5
-
34
-
-
67149121074
-
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
-
Laird MHW, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN (2009). TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85, 966-977.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 966-977
-
-
Laird, M.H.W.1
Rhee, S.H.2
Perkins, D.J.3
Medvedev, A.E.4
Piao, W.5
Fenton, M.J.6
Vogel, S.N.7
-
36
-
-
84908584320
-
TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation
-
Mantegazza AR, Zajac AL, Twelvetrees A, Holzbaur ELF, Amigorena S (2014). TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation. Proc Natl Acad Sci USA 111, 15508-15513.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 15508-15513
-
-
Mantegazza, A.R.1
Zajac, A.L.2
Twelvetrees, A.3
Holzbaur, E.L.F.4
Amigorena, S.5
-
37
-
-
84955200036
-
Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages
-
Mrakovic A, Kay JG, Furuya W, Brumell JH, Botelho RJ (2012). Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages. Traffic 13, 1667-1679.
-
(2012)
Traffic
, vol.13
, pp. 1667-1679
-
-
Mrakovic, A.1
Kay, J.G.2
Furuya, W.3
Brumell, J.H.4
Botelho, R.J.5
-
38
-
-
84899953763
-
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling
-
Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I (2014). Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature 509, 240-244.
-
(2014)
Nature
, vol.509
, pp. 240-244
-
-
Nakamura, N.1
Lill, J.R.2
Phung, Q.3
Jiang, Z.4
Bakalarski, C.5
De Mazière, A.6
Klumperman, J.7
Schlatter, M.8
Delamarre, L.9
Mellman, I.10
-
39
-
-
0032936502
-
CIIV, MIIC and other compartments for MHC class II loading
-
Neefjes J (1999). CIIV, MIIC and other compartments for MHC class II loading. Eur J Immunol 29, 1421-1425.
-
(1999)
Eur J Immunol
, vol.29
, pp. 1421-1425
-
-
Neefjes, J.1
-
40
-
-
0025249197
-
The biosynthetic pathway of MHC class II but not class i molecules intersects the endocytic route
-
Neefjes JJ, Stollorz V, Peters PJ, Geuze HJ, Ploegh HL (1990). The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell 61, 171-183.
-
(1990)
Cell
, vol.61
, pp. 171-183
-
-
Neefjes, J.J.1
Stollorz, V.2
Peters, P.J.3
Geuze, H.J.4
Ploegh, H.L.5
-
41
-
-
84920964478
-
PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester
-
Ni Y, Wang L, Zhang J, Pang Z, Liu Q, Du J (2015). PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester. Int J Biochem Cell Biol 60, 34-42.
-
(2015)
Int J Biochem Cell Biol
, vol.60
, pp. 34-42
-
-
Ni, Y.1
Wang, L.2
Zhang, J.3
Pang, Z.4
Liu, Q.5
Du, J.6
-
42
-
-
50949130076
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
-
Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M, Takeuchi T, Matsuda S, Koyasu S (2008). Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112, 635-643.
-
(2008)
Blood
, vol.112
, pp. 635-643
-
-
Ohtani, M.1
Nagai, S.2
Kondo, S.3
Mizuno, S.4
Nakamura, K.5
Tanabe, M.6
Takeuchi, T.7
Matsuda, S.8
Koyasu, S.9
-
43
-
-
76149086512
-
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
-
Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Øvervatn A, Bjøkøy G, Johansen T (2010). FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 188, 253-269.
-
(2010)
J Cell Biol
, vol.188
, pp. 253-269
-
-
Pankiv, S.1
Alemu, E.A.2
Brech, A.3
Bruun, J.A.4
Lamark, T.5
Øvervatn, A.6
Bjøkøy, G.7
Johansen, T.8
-
44
-
-
0025905925
-
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
-
Peters PJ, Borst J, Oorschot V, Fukuda M, Krähenbühl O, Tschopp J, Slot JW, Geuze HJ (1991). Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J Exp Med 173, 1099-1109.
-
(1991)
J Exp Med
, vol.173
, pp. 1099-1109
-
-
Peters, P.J.1
Borst, J.2
Oorschot, V.3
Fukuda, M.4
Krähenbühl, O.5
Tschopp, J.6
Slot, J.W.7
Geuze, H.J.8
-
45
-
-
84928012389
-
BORC, a multisubunit complex that regulates lysosome positioning
-
Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino JS (2015). BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell 33, 176-188.
-
(2015)
Dev Cell
, vol.33
, pp. 176-188
-
-
Pu, J.1
Schindler, C.2
Jia, R.3
Jarnik, M.4
Backlund, P.5
Bonifacino, J.S.6
-
46
-
-
83455229793
-
Arl8 and SKIP act together to link lysosomes to kinesin-1
-
Rosa-Ferreira C, Munro S (2011). Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev Cell 21, 1171-1178.
-
(2011)
Dev Cell
, vol.21
, pp. 1171-1178
-
-
Rosa-Ferreira, C.1
Munro, S.2
-
47
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G (2002). Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277, 20104-20112.
-
(2002)
J Biol Chem
, vol.277
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
48
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
49
-
-
81155151818
-
Role of the mTOR pathway in LPS-activated monocytes: Influence of hypertonic saline
-
Schaeffer V, Arbabi S, Garcia IA, Knoll ML, Cuschieri J, Bulger EM, Maier RV (2011). Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline. J Surg Res 171, 769-776.
-
(2011)
J Surg Res
, vol.171
, pp. 769-776
-
-
Schaeffer, V.1
Arbabi, S.2
Garcia, I.A.3
Knoll, M.L.4
Cuschieri, J.5
Bulger, E.M.6
Maier, R.V.7
-
50
-
-
84901808450
-
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
-
Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, et al. (2014). The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol 205, 525-540.
-
(2014)
J Cell Biol
, vol.205
, pp. 525-540
-
-
Schiefermeier, N.1
Scheffler, J.M.2
De Araujo, M.E.3
Stasyk, T.4
Yordanov, T.5
Ebner, H.L.6
Offterdinger, M.7
Munck, S.8
Hess, M.W.9
Wickström, S.A.10
-
51
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S, Peterson TR, Sabatini DM (2010). Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40, 310-322.
-
(2010)
Mol Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
52
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, et al. (2012). A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31, 1095-1108.
-
(2012)
EMBO J
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
Zoncu, R.2
Medina, D.L.3
Vetrini, F.4
Erdin, S.5
Erdin, S.6
Huynh, T.7
Ferron, M.8
Karsenty, G.9
Vellard, M.C.10
-
53
-
-
84876812269
-
Signals from the lysosome: A control centre for cellular clearance and energy metabolism
-
Settembre C, Fraldi A, Medina DL, Ballabio A (2013). Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 14, 283-296.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
54
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V, Suzuki A, De la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
55
-
-
34047193517
-
Transport of Streptococcus pneumoniae capsular polysaccharide in MHC class II tubules
-
Stephen TL, Fabri M, Groneck L, Röhhn TA, Hafke H, Robinson N, Rietdorf J, Schrama D, Becker JC, Plum G, et al. (2007). Transport of Streptococcus pneumoniae capsular polysaccharide in MHC class II tubules. PLoS Pathog 3, e32.
-
(2007)
PLoS Pathog
, vol.3
, pp. e32
-
-
Stephen, T.L.1
Fabri, M.2
Groneck, L.3
Röhhn, T.A.4
Hafke, H.5
Robinson, N.6
Rietdorf, J.7
Schrama, D.8
Becker, J.C.9
Plum, G.10
-
56
-
-
0037129212
-
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
-
Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, et al. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416, 750-756.
-
(2002)
Nature
, vol.416
, pp. 750-756
-
-
Suzuki, N.1
Suzuki, S.2
Duncan, G.S.3
Millar, D.G.4
Wada, T.5
Mirtsos, C.6
Takada, H.7
Wakeham, A.8
Itie, A.9
Li, S.10
-
57
-
-
0346018912
-
Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules
-
Swanson J, Bushnell A, Silverstein SC (1987). Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules. Proc Natl Acad Sci USA 84, 1921-1925.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 1921-1925
-
-
Swanson, J.1
Bushnell, A.2
Silverstein, S.C.3
-
58
-
-
0021923854
-
Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages
-
Swanson JA, Yirinec BD, Silverstein SC (1985). Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages. J Cell Biol 100, 851-859.
-
(1985)
J Cell Biol
, vol.100
, pp. 851-859
-
-
Swanson, J.A.1
Yirinec, B.D.2
Silverstein, S.C.3
-
59
-
-
79952999361
-
CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology
-
Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland BR, Malik AR, Wulf PS, Hoogenraad CC, Jaworski J (2011). CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology. J Neurosci 31, 4555-4568.
-
(2011)
J Neurosci
, vol.31
, pp. 4555-4568
-
-
Swiech, L.1
Blazejczyk, M.2
Urbanska, M.3
Pietruszka, P.4
Dortland, B.R.5
Malik, A.R.6
Wulf, P.S.7
Hoogenraad, C.C.8
Jaworski, J.9
-
60
-
-
0033565779
-
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
-
Thomas JA, Allen JL, Tsen M, Dubnicoff T, Danao J, Liao XC, Cao Z, Wasserman SA (1999). Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol 163, 978-984.
-
(1999)
J Immunol
, vol.163
, pp. 978-984
-
-
Thomas, J.A.1
Allen, J.L.2
Tsen, M.3
Dubnicoff, T.4
Danao, J.5
Liao, X.C.6
Cao, Z.7
Wasserman, S.A.8
-
61
-
-
34249779825
-
Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells
-
Vyas JM, Kim Y-M, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL (2007). Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. J Immunol 178, 7199-7210.
-
(2007)
J Immunol
, vol.178
, pp. 7199-7210
-
-
Vyas, J.M.1
Kim, Y.-M.2
Artavanis-Tsakonas, K.3
Love, J.C.4
Van Der Veen, A.G.5
Ploegh, H.L.6
-
62
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Hol WH, Hengstschlüer M, et al. (2008). The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29, 565-577.
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
Rosner, M.4
Zeyda, M.5
Stuhlmeier, K.M.6
Kolbe, T.7
Stulnig, T.M.8
Hol, W.H.9
Hengstschlüer, M.10
-
63
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, et al. (2003a). Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643.
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Hoshino, K.4
Kaisho, T.5
Sanjo, H.6
Takeuchi, O.7
Sugiyama, M.8
Okabe, M.9
Takeda, K.10
-
64
-
-
0242624622
-
TRAM is specifically involved in the Tolllike receptor 4-mediated MyD88-independent signaling pathway
-
Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S (2003b). TRAM is specifically involved in the Tolllike receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4, 1144-1150.
-
(2003)
Nat Immunol
, vol.4
, pp. 1144-1150
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Uematsu, S.4
Hoshino, K.5
Kaisho, T.6
Takeuchi, O.7
Takeda, K.8
Akira, S.9
-
65
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Tolllike receptor signaling
-
Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S (2002). Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Tolllike receptor signaling. J Immunol 169, 6668-6672.
-
(2002)
J Immunol
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
Hoshino, K.4
Takeuchi, O.5
Takeda, K.6
Akira, S.7
-
66
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, et al. (2010). Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465, 942-946.
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
Peng, J.6
Mi, N.7
Zhao, Y.8
Liu, Z.9
Wan, F.10
-
67
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase
-
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM (2011). mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase. Science 334, 678-683.
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
|