Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

Nature

Volumn 418, Issue 6901, 2002, Pages 988-994

  Chow, Amy ^a   Toomre, Derek ^a   Garrett, Wendy ^a   Mellman, Ira ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOLOGICAL MEMBRANES; DIMERS; MICROSCOPIC EXAMINATION; MOLECULES; PROTEINS;

ENDOSOMES;

CELLS;

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

IMMUNE RESPONSE;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELL COMPARTMENTALIZATION; CELL MATURATION; CELL MEMBRANE; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; GENETIC TRANSFECTION; IMMUNE SYSTEM; INTERNALIZATION; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REGULATORY MECHANISM; T LYMPHOCYTE; TRANSPORT KINETICS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; DENDRITIC CELLS; ENDOCYTOSIS; ENDOSOMES; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, VIDEO; PROTEIN TRANSPORT; STEM CELLS;

ANIMALIA;

EID: 0037194733     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01006     Document Type: Article

References (30)

1. Dendritic cells and the control of immunity
2. Dendritic cells: Specialized and regulated antigen processing machines
3. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
4. Developmental control of endocytosis in dendritic cells by Cdc42
5. Developmental regulation of MHC class II transport in mouse dendritic cells
6. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
7. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
8. Transport of peptide-MHC class II complexes in developing dendritic cells
9. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
10. Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation
11. The biogenesis of lysosomes
12. Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells
13. Several mechanisms can account for defective Eα gene expression in different mouse haplotypes
14. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens
15. Fusion of constitutive membrane traffic with the cell surface observed by evanescent wave microscopy
16. A real-time view of life within 100 nm of the plasma membrane
17. Lighting up the cell surface with evanescent wave microscopy
18. Transport, capture and exocytosis of single synaptic vesicles at active zones
19. Imaging constitutive exocytosis with total internal reflection fluorescence microscopy
20. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments
21. Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments
22. Regulated secretion from hemopoietic cells
23. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface
24. B lymphocytes secrete antigen-presenting vesicles
25. Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation
26. Macropinosome maturation and fusion with tubular lysosomes in macrophages
27. Organization of organelles and membrane traffic by microtubules
28. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
29. + T cell help to elicit protective and therapeutic antitumor immunity
30. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus