메뉴 건너뛰기




Volumn 27, Issue 1, 2016, Pages 33-39

Choline metabolites: Gene by diet interactions

Author keywords

choline; gene by diet interactions; polymorphisms

Indexed keywords

CHOLINE; DRUG METABOLITE; METHYLAMINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; PEMT PROTEIN, HUMAN; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; TRIMETHYLOXAMINE;

EID: 84954401404     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0000000000000259     Document Type: Review
Times cited : (30)

References (54)
  • 1
    • 0013612852 scopus 로고
    • The effect of chain length of the dietary fatty acid upon the fatty liver of choline deficiency
    • De Witt Stetten J, Juan Salcedo J. The effect of chain length of the dietary fatty acid upon the fatty liver of choline deficiency. J Nutr. 1945; 167-170.
    • (1945) J Nutr , pp. 167-170
    • De Witt Stetten, J.1    Juan Salcedo, J.2
  • 2
    • 33746504112 scopus 로고    scopus 로고
    • Common genetic polymorphisms affect the human requirement for the nutrient choline
    • da Costa KA, Kozyreva OG, Song J, et al. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J. 2006; 20: 1336-1344.
    • (2006) FASEB J , vol.20 , pp. 1336-1344
    • Da Costa, K.A.1    Kozyreva, O.G.2    Song, J.3
  • 3
    • 3242698799 scopus 로고    scopus 로고
    • Periconceptional dietary intake of choline and betaine and neural tube defects in offspring
    • Shaw GM, Carmichael SL, Yang W, et al. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004; 160: 102-109.
    • (2004) Am J Epidemiol , vol.160 , pp. 102-109
    • Shaw, G.M.1    Carmichael, S.L.2    Yang, W.3
  • 4
    • 84901335706 scopus 로고    scopus 로고
    • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
    • Hartiala J, Bennett BJ, Tang WH, et al. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol. 2014; 34: 1307-1313.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1307-1313
    • Hartiala, J.1    Bennett, B.J.2    Tang, W.H.3
  • 5
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
    • Bennett BJ, de Aguiar Vallim TQ, Wang Z, et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013; 17: 49-60.
    • (2013) Cell Metab , vol.17 , pp. 49-60
    • Bennett, B.J.1    De Aguiar Vallim, T.Q.2    Wang, Z.3
  • 6
    • 84907313170 scopus 로고    scopus 로고
    • Effect of egg ingestion on trimethylamine-N-oxide production in humans: A randomized, controlled, dose-response study
    • Miller CA, Corbin KD, da Costa KA, et al. Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Am J Clin Nutr. 2014; 100: 778-786.
    • (2014) Am J Clin Nutr , vol.100 , pp. 778-786
    • Miller, C.A.1    Corbin, K.D.2    Da Costa, K.A.3
  • 7
    • 73349121672 scopus 로고    scopus 로고
    • Choline and risk of neural tube defects in a folate-fortified population
    • ShawGM, Finnell RH, Blom HJ, et al. Choline and risk of neural tube defects in a folate-fortified population. Epidemiology. 2009; 20: 714-719.
    • (2009) Epidemiology , vol.20 , pp. 714-719
    • Shaw, G.M.1    Finnell, R.H.2    Blom, H.J.3
  • 8
    • 33750107341 scopus 로고    scopus 로고
    • Choline: Critical role during fetal development and dietary requirements in adults
    • Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr. 2006; 26: 229-250.
    • (2006) Annu Rev Nutr , vol.26 , pp. 229-250
    • Zeisel, S.H.1
  • 9
    • 73349128478 scopus 로고    scopus 로고
    • Nested case-control study of onecarbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate
    • Shaw GM, Vollset SE, Carmichael SL, et al. Nested case-control study of onecarbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate. Pediatr Res. 2009; 66: 501-506.
    • (2009) Pediatr Res , vol.66 , pp. 501-506
    • Shaw, G.M.1    Vollset, S.E.2    Carmichael, S.L.3
  • 10
    • 84940398836 scopus 로고    scopus 로고
    • Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort
    • Silver MJ, Corbin KD, Hellenthal G, et al. Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. FASEB J. 2015; 29: 3426-3435.
    • (2015) FASEB J , vol.29 , pp. 3426-3435
    • Silver, M.J.1    Corbin, K.D.2    Hellenthal, G.3
  • 11
    • 84878767602 scopus 로고    scopus 로고
    • Strain-dependent dysregulation of onecarbon metabolism in male mice is associated with choline- and folatedeficient diet-induced liver injury
    • Pogribny IP, Kutanzi K, Melnyk S, et al. Strain-dependent dysregulation of onecarbon metabolism in male mice is associated with choline- And folatedeficient diet-induced liver injury. FASEB J. 2013; 27: 2233-2243.
    • (2013) FASEB J , vol.27 , pp. 2233-2243
    • Pogribny, I.P.1    Kutanzi, K.2    Melnyk, S.3
  • 12
    • 62149129730 scopus 로고    scopus 로고
    • Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted
    • Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc. 2009; 109: 313-318.
    • (2009) J Am Diet Assoc , vol.109 , pp. 313-318
    • Ivanov, A.1    Nash-Barboza, S.2    Hinkis, S.3    Caudill, M.A.4
  • 13
    • 27644581598 scopus 로고    scopus 로고
    • Genetic variation of folatemediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
    • Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH. Genetic variation of folatemediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A. 2005; 102: 16025-16030.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16025-16030
    • Kohlmeier, M.1    Da Costa, K.A.2    Fischer, L.M.3    Zeisel, S.H.4
  • 14
    • 18644379774 scopus 로고    scopus 로고
    • A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the birth defects research group
    • Brody LC, Conley M, Cox C, et al A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet. 2002; 71: 1207-1215.
    • (2002) Am J Hum Genet , vol.71 , pp. 1207-1215
    • Brody, L.C.1    Conley, M.2    Cox, C.3
  • 16
    • 84965091253 scopus 로고    scopus 로고
    • Genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome: A meta-Analysis
    • Balduino Victorino D, de Godoy MF, Goloni-Bertollo EM, Pavarino EC. Genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome: a meta-Analysis. Dis Markers. 2014; 2014: 517504.
    • (2014) Dis Markers , vol.2014 , pp. 517504
    • Balduino Victorino, D.1    De Godoy, M.F.2    Goloni-Bertollo, E.M.3    Pavarino, E.C.4
  • 17
    • 84921029724 scopus 로고    scopus 로고
    • Association between MTHFD1 polymorphisms and neural tube defect susceptibility
    • Meng J, Han L, Zhuang B. Association between MTHFD1 polymorphisms and neural tube defect susceptibility. J Neurol Sci. 2015; 348: 188-194.
    • (2015) J Neurol Sci , vol.348 , pp. 188-194
    • Meng, J.1    Han, L.2    Zhuang, B.3
  • 18
    • 84939994942 scopus 로고    scopus 로고
    • MTHFD1 polymorphism as maternal risk for neural tube defects: A meta-Analysis
    • Zheng J, Lu X, Liu H, et al. MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-Analysis. Neurol Sci. 2015; 36: 607-616.
    • (2015) Neurol Sci , vol.36 , pp. 607-616
    • Zheng, J.1    Lu, X.2    Liu, H.3
  • 19
    • 84880568476 scopus 로고    scopus 로고
    • Plasma choline metabolites associate with metabolic stress among young overweight men in a genotype-specific manner
    • Yan J, Winter LB, Burns-Whitmore B, et al. Plasma choline metabolites associate with metabolic stress among young overweight men in a genotype-specific manner. Nutr Diabetes. 2012; 2: e49.
    • (2012) Nutr Diabetes , vol.2 , pp. e49
    • Yan, J.1    Winter, L.B.2    Burns-Whitmore, B.3
  • 20
    • 84907277018 scopus 로고    scopus 로고
    • Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects
    • Mills JL, Fan R, Brody LC, et al. Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. Am J Clin Nutr. 2014; 100: 1069-1074.
    • (2014) Am J Clin Nutr , vol.100 , pp. 1069-1074
    • Mills, J.L.1    Fan, R.2    Brody, L.C.3
  • 21
    • 84935478537 scopus 로고    scopus 로고
    • Maternal choline status, but not fetal genotype, influences cord plasma choline metabolite concentrations
    • Visentin CE, Masih S, Plumptre L, et al. Maternal choline status, but not fetal genotype, influences cord plasma choline metabolite concentrations. J Nutr. 2015; 145: 1491-1497.
    • (2015) J Nutr , vol.145 , pp. 1491-1497
    • Visentin, C.E.1    Masih, S.2    Plumptre, L.3
  • 22
    • 85027944097 scopus 로고    scopus 로고
    • A critical review: Early life nutrition and prenatal programming for adult disease
    • Epub ahead of print
    • Carolan-Olah M, Duarte-Gardea M, Lechuga J A critical review: early life nutrition and prenatal programming for adult disease. J Clin Nurs 2015. [Epub ahead of print
    • (2015) J Clin Nurs
    • Carolan-Olah, M.1    Duarte-Gardea, M.2    Lechuga, J.3
  • 23
    • 84892572547 scopus 로고    scopus 로고
    • Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the txj mouse model of Wilson disease
    • Medici V, Shibata NM, Kharbanda KK, et al. Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the txj mouse model of Wilson disease. Epigenetics. 2014; 9: 286-296.
    • (2014) Epigenetics , vol.9 , pp. 286-296
    • Medici, V.1    Shibata, N.M.2    Kharbanda, K.K.3
  • 24
    • 84908026635 scopus 로고    scopus 로고
    • Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders
    • Neggers YH. Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders. ISRN Nutr. 2014; 2014: 514026.
    • (2014) ISRN Nutr , vol.2014 , pp. 514026
    • Neggers, Y.H.1
  • 25
    • 84903976099 scopus 로고    scopus 로고
    • Increasing maternal or postweaning folic acid alters gene expression and moderately changes behavior in the offspring
    • Barua S, Chadman KK, Kuizon S, et al. Increasing maternal or postweaning folic acid alters gene expression and moderately changes behavior in the offspring. PLoS One. 2014; 9: e101674.
    • (2014) PLoS One , vol.9 , pp. e101674
    • Barua, S.1    Chadman, K.K.2    Kuizon, S.3
  • 26
    • 84930540996 scopus 로고    scopus 로고
    • Consequences of dietary methyl donor supplements: Ismore always better?
    • Shorter KR, Felder MR, Vrana PB. Consequences of dietary methyl donor supplements: ismore always better? Prog Biophys Mol Biol. 2015; 118: 14-20.
    • (2015) Prog Biophys Mol Biol , vol.118 , pp. 14-20
    • Shorter, K.R.1    Felder, M.R.2    Vrana, P.B.3
  • 27
    • 84899796235 scopus 로고    scopus 로고
    • Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
    • Dominguez-Salas P, Moore SE, Baker MS, et al. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun. 2014; 5: 3746.
    • (2014) Nat Commun , vol.5 , pp. 3746
    • Dominguez-Salas, P.1    Moore, S.E.2    Baker, M.S.3
  • 28
    • 77957949167 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-Analysis of 8 randomized trials involving 37 485 individuals
    • Clarke R, Halsey J, Lewington S, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-Analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010; 170: 1622-1631.
    • (2010) Arch Intern Med , vol.170 , pp. 1622-1631
    • Clarke, R.1    Halsey, J.2    Lewington, S.3
  • 29
    • 77949912889 scopus 로고    scopus 로고
    • Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease
    • Biselli PM, Guerzoni AR, de Godoy MF, et al. Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease. J Thromb Thrombolysis. 2010; 29: 32-40.
    • (2010) J Thromb Thrombolysis , vol.29 , pp. 32-40
    • Biselli, P.M.1    Guerzoni, A.R.2    De Godoy, M.F.3
  • 30
    • 62149125817 scopus 로고    scopus 로고
    • Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease
    • Ghazouani L, Abboud N, Mtiraoui N, et al. Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease. J Thromb Thrombolysis. 2009; 27: 191-197.
    • (2009) J Thromb Thrombolysis , vol.27 , pp. 191-197
    • Ghazouani, L.1    Abboud, N.2    Mtiraoui, N.3
  • 31
    • 84939267933 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians
    • Ramkaran P, Phulukdaree A, Khan S, et al. Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians. Gene. 2015; 571: 28-32.
    • (2015) Gene , vol.571 , pp. 28-32
    • Ramkaran, P.1    Phulukdaree, A.2    Khan, S.3
  • 32
    • 84961288221 scopus 로고    scopus 로고
    • Coronary artery disease and the frequencies of MTHFR and PON1 gene polymorphism studies in a varied population of Hyderabad, Telangana region in south India
    • Matam K, Khan IA, Hasan Q, Rao P. Coronary artery disease and the frequencies of MTHFR and PON1 gene polymorphism studies in a varied population of Hyderabad, Telangana region in south India. J King Saud UnivV 27 2015; 143-150.
    • (2015) J King Saud UnivV , vol.27 , pp. 143-150
    • Matam, K.1    Khan, I.A.2    Hasan, Q.3    Rao, P.4
  • 33
    • 84928427965 scopus 로고    scopus 로고
    • Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-Analysis
    • Hou X, Chen X, Shi J. Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: a meta-Analysis. Gene. 2015; 565: 39-44.
    • (2015) Gene , vol.565 , pp. 39-44
    • Hou, X.1    Chen, X.2    Shi, J.3
  • 34
    • 84927534831 scopus 로고    scopus 로고
    • Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: The CSPPT randomized clinical trial
    • Huo Y, Li J, Qin X, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015; 313: 1325-1335.
    • (2015) JAMA , vol.313 , pp. 1325-1335
    • Huo, Y.1    Li, J.2    Qin, X.3
  • 35
    • 84962884331 scopus 로고    scopus 로고
    • Relationship of MTHFR gene polymorphisms with renal and cardiac disease
    • Trovato FM, Catalano D, Ragusa A, et al. Relationship of MTHFR gene polymorphisms with renal and cardiac disease. World J Nephrol. 2015; 4: 127-137.
    • (2015) World J Nephrol , vol.4 , pp. 127-137
    • Trovato, F.M.1    Catalano, D.2    Ragusa, A.3
  • 36
    • 84875781416 scopus 로고    scopus 로고
    • Loci influencing blood pressure identified using a cardiovascular gene-centric array
    • Ganesh SK, Tragante V, Guo W, et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 2013; 22: 1663-1678.
    • (2013) Hum Mol Genet , vol.22 , pp. 1663-1678
    • Ganesh, S.K.1    Tragante, V.2    Guo, W.3
  • 37
    • 84889677629 scopus 로고    scopus 로고
    • Association of common variants in/near six genes (atp2b1, csk, mthfr, cyp17a1, stk39 and fgf5) with blood pressure/hypertension risk in Chinese children
    • Xi B, Shen Y, Zhao X, et al. Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children. J Hum Hypertens. 2014; 28: 32-36.
    • (2014) J Hum Hypertens , vol.28 , pp. 32-36
    • Xi, B.1    Shen, Y.2    Zhao, X.3
  • 38
    • 84890291842 scopus 로고    scopus 로고
    • Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits
    • Benton MC, Lea RA, Macartney-Coxson D, et al. Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits. Am J Hum Genet. 2013; 93: 1087-1099.
    • (2013) Am J Hum Genet , vol.93 , pp. 1087-1099
    • Benton, M.C.1    Lea, R.A.2    Macartney-Coxson, D.3
  • 39
    • 84897479338 scopus 로고    scopus 로고
    • Gene-centric meta-Analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations
    • Yoneyama S, Guo Y, Lanktree MB, et al. Gene-centric meta-Analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014; 23: 2498-2510.
    • (2014) Hum Mol Genet , vol.23 , pp. 2498-2510
    • Yoneyama, S.1    Guo, Y.2    Lanktree, M.B.3
  • 40
    • 84894279706 scopus 로고    scopus 로고
    • Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet
    • Al Rajabi A, Castro GS, da Silva RP, et al. Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. J Nutr. 2014; 144: 252-257.
    • (2014) J Nutr , vol.144 , pp. 252-257
    • Al Rajabi, A.1    Castro, G.S.2    Da Silva, R.P.3
  • 41
    • 69849104511 scopus 로고    scopus 로고
    • Lack of phosphatidylethanolamine Nmethyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice
    • Zhao Y, Su B, Jacobs RL, et al. Lack of phosphatidylethanolamine Nmethyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2009; 29: 1349-1355.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1349-1355
    • Zhao, Y.1    Su, B.2    Jacobs, R.L.3
  • 42
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • Dumas ME, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A. 2006; 103: 12511-12516.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12511-12516
    • Dumas, M.E.1    Barton, R.H.2    Toye, A.3
  • 43
    • 79551577263 scopus 로고    scopus 로고
    • Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes
    • Musso G, Gambino R, Cassader M. Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. Annu Rev Med. 2011; 62: 361-380.
    • (2011) Annu Rev Med , vol.62 , pp. 361-380
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 44
    • 84888187402 scopus 로고    scopus 로고
    • Gut microbiota metabolism of L-carnitine and cardiovascular risk
    • Ussher JR, Lopaschuk GD, Arduini A. Gut microbiota metabolism of L-carnitine and cardiovascular risk. Atherosclerosis. 2013; 231: 456-461.
    • (2013) Atherosclerosis , vol.231 , pp. 456-461
    • Ussher, J.R.1    Lopaschuk, G.D.2    Arduini, A.3
  • 45
    • 84886743078 scopus 로고    scopus 로고
    • Potential role of gastrointestinal microbiota composition in prostate cancer risk
    • Amirian ES, Petrosino JF, Ajami NJ, et al. Potential role of gastrointestinal microbiota composition in prostate cancer risk. Infect Agent Cancer. 2013; 8: 42.
    • (2013) Infect Agent Cancer , vol.8 , pp. 42
    • Amirian, E.S.1    Petrosino, J.F.2    Ajami, N.J.3
  • 46
    • 79952316380 scopus 로고    scopus 로고
    • Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency
    • Spencer MD, Hamp TJ, Reid RW, et al. Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. 2011; 140: 976-986.
    • (2011) Gastroenterology , vol.140 , pp. 976-986
    • Spencer, M.D.1    Hamp, T.J.2    Reid, R.W.3
  • 47
    • 84907486084 scopus 로고    scopus 로고
    • The contributory role of gut microbiota in cardiovascular disease
    • Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovascular disease. J Clin Invest. 2014; 124: 4204-4211.
    • (2014) J Clin Invest , vol.124 , pp. 4204-4211
    • Tang, W.H.1    Hazen, S.L.2
  • 48
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-Noxide
    • Wang Z, Tang WH, Buffa JA, et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-Noxide. Eur Heart J. 2014; 35: 904-910.
    • (2014) Eur Heart J , vol.35 , pp. 904-910
    • Wang, Z.1    Tang, W.H.2    Buffa, J.A.3
  • 49
    • 84930004775 scopus 로고    scopus 로고
    • Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide
    • Romano KA, Vivas EI, Amador-Noguez D, Rey FE. Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio. 2015; 6: e02481.
    • (2015) MBio , vol.6 , pp. e02481
    • Romano, K.A.1    Vivas, E.I.2    Amador-Noguez, D.3    Rey, F.E.4
  • 50
    • 84920704729 scopus 로고    scopus 로고
    • Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
    • Shih DM, Wang Z, Lee R, et al. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015; 56: 22-37.
    • (2015) J Lipid Res , vol.56 , pp. 22-37
    • Shih, D.M.1    Wang, Z.2    Lee, R.3
  • 51
    • 84921362010 scopus 로고    scopus 로고
    • The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance
    • Warrier M, Shih DM, Burrows AC, et al. The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance. Cell Reports. 2015; 10: 326-338.
    • (2015) Cell Reports , vol.10 , pp. 326-338
    • Warrier, M.1    Shih, D.M.2    Burrows, A.C.3
  • 52
    • 84903750686 scopus 로고    scopus 로고
    • Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups
    • da Costa KA, Corbin KD, Niculescu MD, et al. Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. FASEB J. 2014; 28: 2970-2978.
    • (2014) FASEB J , vol.28 , pp. 2970-2978
    • Da Costa, K.A.1    Corbin, K.D.2    Niculescu, M.D.3
  • 53
    • 84932640531 scopus 로고    scopus 로고
    • Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts
    • Schenkel LC, Singh RK, Michel V, et al. Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts. FASEB J. 2015; 29: 1663-1675.
    • (2015) FASEB J , vol.29 , pp. 1663-1675
    • Schenkel, L.C.1    Singh, R.K.2    Michel, V.3
  • 54
    • 84879867981 scopus 로고    scopus 로고
    • A genome-wide association study of the human metabolome in a community-based cohort
    • Rhee EP, Ho JE, Chen MH, et al A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab. 2013; 18: 130-143.
    • (2013) Cell Metab , vol.18 , pp. 130-143
    • Rhee, E.P.1    Ho, J.E.2    Chen, M.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.