Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury

FASEB Journal

Volumn 27, Issue 6, 2013, Pages 2233-2243

  Pogribny, Igor P ^a   Kutanzi, Kristy ^a   Melnyk, Stepan ^a   De Conti, Aline ^a   Tryndyak, Volodymyr ^a   Montgomery, Beverly ^a   Pogribna, Marta ^a   Muskhelishvili, Levan ^a   Latendresse, John R ^a   James, S Jill ^b   Beland, Frederick A ^a   Rusyn, Ivan ^c  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c University of North Carolina at Chapel Hill   (United States)

Author keywords

Gene expression; Homocysteinemia; Methyl donor deficiency; NAFLD; Strain differences

Indexed keywords

ADENOSYL HOMOCYSTEINASE; CARBON; CCAAT ENHANCER BINDING PROTEIN BETA; CHOLINE; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; HOMOCYSTEINE; METHIONINE ADENOSYLTRANSFERAS 1 ALPHA; METHIONINE ADENOSYLTRANSFERASE; METHYLENETETRAHYDRO FOLATE REDUCTASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON METABOLISM; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FATTY LIVER; FIBROGENESIS; GENETIC TRANSCRIPTION; HEPATITIS; HYPERHOMOCYSTEINEMIA; IMMUNOHISTOCHEMISTRY; LIVER NECROSIS; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; ONE CARBON METABOLISM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

GENE EXPRESSION; HOMOCYSTEINEMIA; METHYL DONOR DEFICIENCY; NAFLD; STRAIN DIFFERENCES;

ANIMALS; CARBON; CHOLINE; CHOLINE DEFICIENCY; CYSTATHIONINE BETA-SYNTHASE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FATTY LIVER; FOLIC ACID; FOLIC ACID DEFICIENCY; HUMANS; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, INBRED STRAINS; SPECIES SPECIFICITY;

MUS;

EID: 84878767602     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-227116     Document Type: Article

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