Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort

FASEB Journal

Volumn 29, Issue 8, 2015, Pages 3426-3435

  Silver, Matt J ^a,b   Corbin, Karen D ^c,d   Hellenthal, Garrett ^e   Da Costa, Kerry Ann ^f   Dominguez Salas, Paula ^a,b   Moore, Sophie E ^a   Owen, Jennifer ^c   Prentice, Andrew M ^a,b   Hennig, Branwen J ^a,b   Zeisel, Steven H ^c,d  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d University of North Carolina   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f Toxicology Services   (United States)

Author keywords

Adequate intake levels; Choline dehydrogenase; Diet and selection; Methylenetetrahydrofolate dehydrogenase; Phosphatidylethanolamine N methyltransferase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2) 1; CHOLINE; CHOLINE DEHYDROGENASE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; UNCLASSIFIED DRUG; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ETHNIC GROUP; FEMALE; GAMBIAN; GENE FREQUENCY; GENETIC MODEL; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NORMAL HUMAN; PHENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; DIET; GENETICS; METABOLISM; PROCEDURES;

CHOLINE; CHOLINE DEHYDROGENASE; DIET; ETHNIC GROUPS; FEMALE; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84940398836     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-271056     Document Type: Article

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