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Volumn 34, Issue 1, 2016, Pages 27-33

Concise Review: Exciting Cells: Modeling Genetic Epilepsies with Patient-Derived Induced Pluripotent Stem Cells

Author keywords

Channelopathies; Drug discovery; Epilepsy; Human induced pluripotent stem cells; Patient specific modeling

Indexed keywords

ASTROCYTE; CHANNELOPATHY; DISEASE MODEL; EPILEPSY; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; REVIEW; ANIMAL; CYTOLOGY; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY;

EID: 84954387235     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2203     Document Type: Review
Times cited : (40)

References (55)
  • 1
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 2
    • 77953879152 scopus 로고    scopus 로고
    • Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases
    • Marchetto MC, Winner B, Gage FH,. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet 2010; 19: R71-R76.
    • (2010) Hum Mol Genet , vol.19 , pp. R71-R76
    • Marchetto, M.C.1    Winner, B.2    Gage, F.H.3
  • 3
    • 84874817493 scopus 로고    scopus 로고
    • An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells
    • Okita K, Yamakawa T, Matsumura Y, et al., An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells 2013; 31: 458-466.
    • (2013) Stem Cells , vol.31 , pp. 458-466
    • Okita, K.1    Yamakawa, T.2    Matsumura, Y.3
  • 4
    • 79953021243 scopus 로고    scopus 로고
    • Development of defective and persistent Sendai virus vector a unique gene delivery/expression system ideal for cell reprogramming
    • Nishimura K, Sano M, Ohtaka M, et al., Development of defective and persistent Sendai virus vector a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem 2011; 286: 4760-4771.
    • (2011) J Biol Chem , vol.286 , pp. 4760-4771
    • Nishimura, K.1    Sano, M.2    Ohtaka, M.3
  • 5
    • 79955634826 scopus 로고    scopus 로고
    • A more efficient method to generate integration-free human iPS cells
    • Okita K, Matsumura Y, Sato Y, et al., A more efficient method to generate integration-free human iPS cells. Nat Methods 2011; 8: 409-412.
    • (2011) Nat Methods , vol.8 , pp. 409-412
    • Okita, K.1    Matsumura, Y.2    Sato, Y.3
  • 6
    • 58949094552 scopus 로고    scopus 로고
    • Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
    • Marion RM, Strati K, Li H, et al., Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 2009; 4: 141-154.
    • (2009) Cell Stem Cell , vol.4 , pp. 141-154
    • Marion, R.M.1    Strati, K.2    Li, H.3
  • 7
    • 84901414493 scopus 로고    scopus 로고
    • Stem cells on the brain: Modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells
    • Srikanth P, Young-Pearse TL,. Stem cells on the brain: Modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet 2014; 28: 5-29.
    • (2014) J Neurogenet , vol.28 , pp. 5-29
    • Srikanth, P.1    Young-Pearse, T.L.2
  • 8
    • 84884288934 scopus 로고    scopus 로고
    • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
    • Ran FA, Hsu PD, Lin C-Y, et al., Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 2013; 154: 1380-1389.
    • (2013) Cell , vol.154 , pp. 1380-1389
    • Ran, F.A.1    Hsu, P.D.2    Lin, C.-Y.3
  • 9
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • Schwank G, Koo B-K, Sasselli V, et al., Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013; 13: 653-658.
    • (2013) Cell Stem Cell , vol.13 , pp. 653-658
    • Schwank, G.1    Koo, B.-K.2    Sasselli, V.3
  • 10
    • 84895528015 scopus 로고    scopus 로고
    • Isolation of single-base genome-edited human iPS cells without antibiotic selection
    • Miyaoka Y, Chan AH, Judge LM, et al., Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nat Methods 2014; 11: 291-293.
    • (2014) Nat Methods , vol.11 , pp. 291-293
    • Miyaoka, Y.1    Chan, A.H.2    Judge, L.M.3
  • 11
    • 33846604242 scopus 로고    scopus 로고
    • How common are the "common" neurologic disorders?
    • Hirtz D, Thurman D, Gwinn-Hardy K, et al., How common are the "common" neurologic disorders? Neurology 2007; 68: 326-337.
    • (2007) Neurology , vol.68 , pp. 326-337
    • Hirtz, D.1    Thurman, D.2    Gwinn-Hardy, K.3
  • 12
    • 24944576673 scopus 로고    scopus 로고
    • Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: A prospective study
    • Olafsson E, Ludvigsson P, Hesdorffer D, et al., Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: A prospective study. Lancet Neurol 2005; 4: 627-634.
    • (2005) Lancet Neurol , vol.4 , pp. 627-634
    • Olafsson, E.1    Ludvigsson, P.2    Hesdorffer, D.3
  • 13
    • 84911966458 scopus 로고    scopus 로고
    • Sudden unexpected death in epilepsy: Assessing the public health burden
    • Thurman DJ, Hesdorffer DC, French JA,. Sudden unexpected death in epilepsy: Assessing the public health burden. Epilepsia 2014; 55: 1479-1485.
    • (2014) Epilepsia , vol.55 , pp. 1479-1485
    • Thurman, D.J.1    Hesdorffer, D.C.2    French, J.A.3
  • 14
    • 0025368281 scopus 로고
    • Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA Lys mutation
    • Shoffner JM, Lott MT, Lezza AM, et al., Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA Lys mutation. Cell 1990; 61: 931-937.
    • (1990) Cell , vol.61 , pp. 931-937
    • Shoffner, J.M.1    Lott, M.T.2    Lezza, A.M.3
  • 15
    • 84923698562 scopus 로고    scopus 로고
    • Pathway-driven discovery of epilepsy genes
    • Noebels J,. Pathway-driven discovery of epilepsy genes. Nat Neurosci 2015; 18: 344-350.
    • (2015) Nat Neurosci , vol.18 , pp. 344-350
    • Noebels, J.1
  • 16
    • 79953685960 scopus 로고    scopus 로고
    • The pharmacologic treatment of Dravet syndrome
    • Chiron C, Dulac O,. The pharmacologic treatment of Dravet syndrome. Epilepsia 2011; 52: 72-75.
    • (2011) Epilepsia , vol.52 , pp. 72-75
    • Chiron, C.1    Dulac, O.2
  • 17
    • 84879684377 scopus 로고    scopus 로고
    • Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1
    • Carvill GL, Heavin SB, Yendle SC, et al., Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nat Genet 2013; 45: 825-830.
    • (2013) Nat Genet , vol.45 , pp. 825-830
    • Carvill, G.L.1    Heavin, S.B.2    Yendle, S.C.3
  • 18
    • 84893440324 scopus 로고    scopus 로고
    • Sodium channel SCN8A (Nav1. 6): Properties and de novo mutations in epileptic encephalopathy and intellectual disability
    • O'Brien JE, Meisler MH,. Sodium channel SCN8A (Nav1. 6): Properties and de novo mutations in epileptic encephalopathy and intellectual disability. Front Genet 2013; 4.
    • (2013) Front Genet , vol.4
    • O'Brien, J.E.1    Meisler, M.H.2
  • 19
    • 84884130368 scopus 로고    scopus 로고
    • De novo mutations in epileptic encephalopathies
    • Phenome E, Consortium EK,. De novo mutations in epileptic encephalopathies. Nature 2013; 501: 217-221.
    • (2013) Nature , vol.501 , pp. 217-221
    • Phenome, E.1    Consortium, E.K.2
  • 20
    • 0344672944 scopus 로고    scopus 로고
    • Mutations of sodium channel α subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures
    • Fujiwara T, Sugawara T, Mazaki-Miyazaki E, et al., Mutations of sodium channel α subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures. Brain 2003; 126: 531-546.
    • (2003) Brain , vol.126 , pp. 531-546
    • Fujiwara, T.1    Sugawara, T.2    Mazaki-Miyazaki, E.3
  • 21
    • 84929502090 scopus 로고    scopus 로고
    • The SCN1A mutation database: Updating information and analysis of the relationships among genotype, functional alteration, and phenotype
    • Meng H, Xu HQ, Yu L, et al., The SCN1A mutation database: Updating information and analysis of the relationships among genotype, functional alteration, and phenotype. Hum Mutat 2015; 36: 573-580.
    • (2015) Hum Mutat , vol.36 , pp. 573-580
    • Meng, H.1    Xu, H.Q.2    Yu, L.3
  • 22
    • 84859744583 scopus 로고    scopus 로고
    • Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures
    • Zeng H, Shen EH, Hohmann JG, et al., Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell 2012; 149: 483-496.
    • (2012) Cell , vol.149 , pp. 483-496
    • Zeng, H.1    Shen, E.H.2    Hohmann, J.G.3
  • 23
    • 84876223311 scopus 로고    scopus 로고
    • Rett syndrome and epilepsy: An update for child neurologists
    • Dolce A, Ben-Zeev B, Naidu S, et al., Rett syndrome and epilepsy: An update for child neurologists. Pediatr Neurol 2013; 48: 337-345.
    • (2013) Pediatr Neurol , vol.48 , pp. 337-345
    • Dolce, A.1    Ben-Zeev, B.2    Naidu, S.3
  • 24
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto MC, Carromeu C, Acab A, et al., A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010; 143: 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3
  • 25
    • 79955602167 scopus 로고    scopus 로고
    • Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
    • Cheung AY, Horvath LM, Grafodatskaya D, et al., Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum Mol Genet 2011; 20: 2103-2115.
    • (2011) Hum Mol Genet , vol.20 , pp. 2103-2115
    • Cheung, A.Y.1    Horvath, L.M.2    Grafodatskaya, D.3
  • 26
    • 65549144456 scopus 로고    scopus 로고
    • Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions
    • Maezawa I, Swanberg S, Harvey D, et al., Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci 2009; 29: 5051-5061.
    • (2009) J Neurosci , vol.29 , pp. 5051-5061
    • Maezawa, I.1    Swanberg, S.2    Harvey, D.3
  • 27
    • 84865773360 scopus 로고    scopus 로고
    • CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons
    • Ricciardi S, Ungaro F, Hambrock M, et al., CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. Nat Cell Biol 2012; 14: 911-923.
    • (2012) Nat Cell Biol , vol.14 , pp. 911-923
    • Ricciardi, S.1    Ungaro, F.2    Hambrock, M.3
  • 28
    • 84921411214 scopus 로고    scopus 로고
    • GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells
    • Livide G, Patriarchi T, Amenduni M, et al., GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. Eur J Hum Genet 2015; 23: 195-201.
    • (2015) Eur J Hum Genet , vol.23 , pp. 195-201
    • Livide, G.1    Patriarchi, T.2    Amenduni, M.3
  • 29
    • 77649209695 scopus 로고    scopus 로고
    • 22q13. 3 deletion syndrome: Clinical and molecular analysis using array CGH
    • Dhar S, Del Gaudio D, German J, et al., 22q13. 3 deletion syndrome: Clinical and molecular analysis using array CGH. Am J Med Genet Part A 2010; 152: 573-581.
    • (2010) Am J Med Genet Part A , vol.152 , pp. 573-581
    • Dhar, S.1    Del Gaudio, D.2    German, J.3
  • 30
    • 84887627330 scopus 로고    scopus 로고
    • SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients
    • Shcheglovitov A, Shcheglovitova O, Yazawa M, et al., SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature 2013; 503: 267-271.
    • (2013) Nature , vol.503 , pp. 267-271
    • Shcheglovitov, A.1    Shcheglovitova, O.2    Yazawa, M.3
  • 31
    • 1642295079 scopus 로고    scopus 로고
    • Psychopharmacology in fragile X syndrome - Present and future
    • Berry-Kravis E, Potanos K,. Psychopharmacology in fragile X syndrome-Present and future. Ment Retard Dev Disabil Res Rev 2004; 10: 42-48.
    • (2004) Ment Retard Dev Disabil Res Rev , vol.10 , pp. 42-48
    • Berry-Kravis, E.1    Potanos, K.2
  • 32
    • 84865064735 scopus 로고    scopus 로고
    • Signaling defects in iPSC-derived fragile X premutation neurons
    • Liu J, Kos̈cielska KA, Cao Z, et al., Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet 2012: dds207.
    • (2012) Hum Mol Genet , pp. dds207
    • Liu, J.1    Kos̈cielska, K.A.2    Cao, Z.3
  • 33
    • 84920815607 scopus 로고    scopus 로고
    • Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells
    • Halevy T, Czech C, Benvenisty N,. Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells. Stem Cell Rep 2015; 4: 37-46.
    • (2015) Stem Cell Rep , vol.4 , pp. 37-46
    • Halevy, T.1    Czech, C.2    Benvenisty, N.3
  • 34
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • Yazawa M, Hsueh B, Jia X, et al., Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 2011; 471: 230-234.
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1    Hsueh, B.2    Jia, X.3
  • 35
    • 84856088804 scopus 로고    scopus 로고
    • Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
    • Paşca SP, Portmann T, Voineagu I, et al., Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med 2011; 17: 1657-1662.
    • (2011) Nat Med , vol.17 , pp. 1657-1662
    • Paşca, S.P.1    Portmann, T.2    Voineagu, I.3
  • 36
    • 84876839257 scopus 로고    scopus 로고
    • A human Dravet syndrome model from patient induced pluripotent stem cells
    • Higurashi N, Uchida T, Lossin C, et al., A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain 2013; 6: 19.
    • (2013) Mol Brain , vol.6 , pp. 19
    • Higurashi, N.1    Uchida, T.2    Lossin, C.3
  • 37
    • 84885724899 scopus 로고    scopus 로고
    • Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons
    • Jiao J, Yang Y, Shi Y, et al., Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons. Hum Mol Genet 2013; 22: 4241-4252.
    • (2013) Hum Mol Genet , vol.22 , pp. 4241-4252
    • Jiao, J.1    Yang, Y.2    Shi, Y.3
  • 38
    • 84883302304 scopus 로고    scopus 로고
    • Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism
    • Liu Y, Lopez-Santiago LF, Yuan Y, et al., Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Ann Neurol 2013; 74: 128-139.
    • (2013) Ann Neurol , vol.74 , pp. 128-139
    • Liu, Y.1    Lopez-Santiago, L.F.2    Yuan, Y.3
  • 39
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Itzhaki I, Maizels L, Huber I, et al., Modelling the long QT syndrome with induced pluripotent stem cells. Nature 2011; 471: 225-229.
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3
  • 40
    • 84863213874 scopus 로고    scopus 로고
    • Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease
    • Davis RP, Casini S, van den Berg CW, et al., Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation 2012; 125: 3079-3091.
    • (2012) Circulation , vol.125 , pp. 3079-3091
    • Davis, R.P.1    Casini, S.2    Van Den Berg, C.W.3
  • 41
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    • Moretti A, Bellin M, Welling A, et al., Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 2010; 363: 1397-1409.
    • (2010) N Engl J Med , vol.363 , pp. 1397-1409
    • Moretti, A.1    Bellin, M.2    Welling, A.3
  • 42
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu B-Y, Weick JP, Yu J, et al., Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci USA 2010; 107: 4335-4340.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4335-4340
    • Hu, B.-Y.1    Weick, J.P.2    Yu, J.3
  • 43
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K, Doi A, Wen B, et al., Epigenetic memory in induced pluripotent stem cells. Nature 2010; 467: 285-290.
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1    Doi, A.2    Wen, B.3
  • 44
    • 79953267538 scopus 로고    scopus 로고
    • A bioinformatic assay for pluripotency in human cells
    • Müller F-J, Schuldt BM, Williams R, et al., A bioinformatic assay for pluripotency in human cells. Nat Methods 2011; 8: 315-317.
    • (2011) Nat Methods , vol.8 , pp. 315-317
    • Müller, F.-J.1    Schuldt, B.M.2    Williams, R.3
  • 45
    • 84885850258 scopus 로고    scopus 로고
    • Opportunities and challenges of pluripotent stem cell neurodegenerative disease models
    • Sandoe J, Eggan K,. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci 2013; 16: 780-789.
    • (2013) Nat Neurosci , vol.16 , pp. 780-789
    • Sandoe, J.1    Eggan, K.2
  • 46
    • 84877301288 scopus 로고    scopus 로고
    • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
    • Nicholas CR, Chen J, Tang Y, et al., Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 2013; 12: 573-586.
    • (2013) Cell Stem Cell , vol.12 , pp. 573-586
    • Nicholas, C.R.1    Chen, J.2    Tang, Y.3
  • 47
    • 84879403017 scopus 로고    scopus 로고
    • Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells
    • Tang X, Zhou L, Wagner AM, et al., Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res 2013; 11: 743-757.
    • (2013) Stem Cell Res , vol.11 , pp. 743-757
    • Tang, X.1    Zhou, L.2    Wagner, A.M.3
  • 48
    • 84904753399 scopus 로고    scopus 로고
    • Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy
    • Sukigara S, Dai H, Nabatame S, et al., Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy. J Neuropathol Exp Neurol 2014; 73: 798-806.
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 798-806
    • Sukigara, S.1    Dai, H.2    Nabatame, S.3
  • 49
    • 67651100884 scopus 로고    scopus 로고
    • Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation
    • Moore AR, Filipovic R, Mo Z, et al., Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation. Cereb Cortex 2009; 19: 1795-1805.
    • (2009) Cereb Cortex , vol.19 , pp. 1795-1805
    • Moore, A.R.1    Filipovic, R.2    Mo, Z.3
  • 50
    • 84929428248 scopus 로고    scopus 로고
    • Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
    • Bardy C, van den Hurk M, Eames T, et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci 2015: 201504393.
    • (2015) Proc Natl Acad Sci , pp. 201504393
    • Bardy, C.1    Van Den Hurk, M.2    Eames, T.3
  • 51
    • 84898034713 scopus 로고    scopus 로고
    • Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
    • Wainger BJ, Kiskinis E, Mellin C, et al., Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep 2014; 7: 1-11.
    • (2014) Cell Rep , vol.7 , pp. 1-11
    • Wainger, B.J.1    Kiskinis, E.2    Mellin, C.3
  • 52
    • 84867233159 scopus 로고    scopus 로고
    • Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set
    • McConnell ER, McClain MA, Ross J, et al., Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set. Neurotoxicology 2012; 33: 1048-1057.
    • (2012) Neurotoxicology , vol.33 , pp. 1048-1057
    • McConnell, E.R.1    McClain, M.A.2    Ross, J.3
  • 53
    • 84884414984 scopus 로고    scopus 로고
    • Cerebral organoids model human brain development and microcephaly
    • Lancaster MA, Renner M, Martin C-A, et al., Cerebral organoids model human brain development and microcephaly. Nature 2013; 501: 373-379.
    • (2013) Nature , vol.501 , pp. 373-379
    • Lancaster, M.A.1    Renner, M.2    Martin, C.-A.3
  • 54
    • 84873282055 scopus 로고    scopus 로고
    • Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo
    • Espuny-Camacho I, Michelsen KA, Gall D, et al., Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron 2013; 77: 440-456.
    • (2013) Neuron , vol.77 , pp. 440-456
    • Espuny-Camacho, I.1    Michelsen, K.A.2    Gall, D.3
  • 55
    • 84922639322 scopus 로고    scopus 로고
    • HPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice
    • Cunningham M, Cho J-H, Leung A, et al., hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 2014; 15: 559-573.
    • (2014) Cell Stem Cell , vol.15 , pp. 559-573
    • Cunningham, M.1    Cho, J.-H.2    Leung, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.