The activation mechanism of glycoprotein hormone receptors with implications in the cause and therapy of endocrine diseases

Journal of Biological Chemistry

Volumn 291, Issue 2, 2016, Pages 508-520

  Brüser, Antje ^a   Schulz, Angela ^a   Rothemund, Sven ^a   Ricken, Albert ^a   Calebiro, Davide ^b   Kleinau, Gunnar ^c   Schöneberg, Torsten ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHEMICAL ACTIVATION; DISEASE CONTROL; ENDOCRINOLOGY; ENZYME ACTIVITY; HORMONES; LIGANDS; PEPTIDES; PROTEINS;

ACTIVATION MECHANISMS; EXTRACELLULAR LIGANDS; G PROTEIN ACTIVATION; G PROTEIN COUPLED RECEPTORS; GLYCOPROTEIN HORMONE RECEPTORS; GLYCOPROTEIN HORMONES; SELECTIVE INTERACTION; THYROID STIMULATING HORMONES;

GLYCOPROTEINS;

GLYCOPROTEIN HORMONE RECEPTOR; HORMONE RECEPTOR; THYROID ANTIBODY; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG; ANTIBODY; CELL SURFACE RECEPTOR; CYCLIC AMP; GLYCOPROTEIN; MUTANT PROTEIN; PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOCRINE DISEASE; IN VITRO STUDY; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS CELL LINE; ENDOCRINE SYSTEM DISEASES; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; MUTAGENESIS; MUTATION; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; THYROID GLAND;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; ENDOCRINE SYSTEM DISEASES; GLYCOPROTEINS; HUMANS; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; MUTATION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; THYROID GLAND;

EID: 84954190840     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.701102     Document Type: Article

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