메뉴 건너뛰기




Volumn 19, Issue 8, 2005, Pages 2086-2098

Zero-length cross-linking reveals that tight interactions between the extracellular and transmembrane domains of the luteinizing hormone receptor persist during receptor activation

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHORIONIC GONADOTROPIN; CYCLIC AMP; DISULFIDE; FURIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR;

EID: 23744497499     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0378     Document Type: Article
Times cited : (26)

References (45)
  • 1
    • 0032247323 scopus 로고    scopus 로고
    • The thyrotropin (TSH) receptor: Interaction with TSH and autoantibodies
    • Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19:673-716
    • (1998) Endocr Rev , vol.19 , pp. 673-716
    • Rapoport, B.1    Chazenbalk, G.D.2    Jaume, J.C.3    McLachlan, S.M.4
  • 2
    • 0036217072 scopus 로고    scopus 로고
    • The lutropin/choriogonadotropin receptor, a 2002 perspective
    • Ascoli M, Fanelli F, Segaloff DL 2002 The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 23:141-174
    • (2002) Endocr Rev , vol.23 , pp. 141-174
    • Ascoli, M.1    Fanelli, F.2    Segaloff, D.L.3
  • 3
    • 0035668921 scopus 로고    scopus 로고
    • Structural biology of human follitropin and its receptor
    • Dias JA, Van Roey P 2001 Structural biology of human follitropin and its receptor. Arch Med Res 32:510-519
    • (2001) Arch Med Res , vol.32 , pp. 510-519
    • Dias, J.A.1    Van Roey, P.2
  • 4
    • 0033054119 scopus 로고    scopus 로고
    • Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling
    • Alvarez CA, Narayan P, Huang J, Puett D 1999 Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling. Endocrinology 140:1775-1782
    • (1999) Endocrinology , vol.140 , pp. 1775-1782
    • Alvarez, C.A.1    Narayan, P.2    Huang, J.3    Puett, D.4
  • 7
    • 0025739241 scopus 로고
    • Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis
    • Ji IH, Ji TH 1991 Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis. J Biol Chem 266:13076-13079
    • (1991) J Biol Chem , vol.266 , pp. 13076-13079
    • Ji, I.H.1    Ji, T.H.2
  • 8
    • 0025759135 scopus 로고
    • Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site
    • Ji I, Ji TH 1991 Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site. Endocrinology 128:2648-2650
    • (1991) Endocrinology , vol.128 , pp. 2648-2650
    • Ji, I.1    Ji, T.H.2
  • 9
    • 0034730516 scopus 로고    scopus 로고
    • Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region
    • Nakabayashi K, Kudo M, Kobilka B, Hsueh AJ 2000 Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region. J Biol Chem 275:30264-30271
    • (2000) J Biol Chem , vol.275 , pp. 30264-30271
    • Nakabayashi, K.1    Kudo, M.2    Kobilka, B.3    Hsueh, A.J.4
  • 10
    • 0030830146 scopus 로고    scopus 로고
    • Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281→isoleucine) in the extracellular domain of the thyrotropin receptor
    • Kopp P, Muirhead S, Jourdain N, Gu WX, Jameson JL, Rodd C 1997 Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281→isoleucine) in the extracellular domain of the thyrotropin receptor. J Clin Invest 100:1634-1639
    • (1997) J Clin Invest , vol.100 , pp. 1634-1639
    • Kopp, P.1    Muirhead, S.2    Jourdain, N.3    Gu, W.X.4    Jameson, J.L.5    Rodd, C.6
  • 11
    • 0034457935 scopus 로고    scopus 로고
    • The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: Implications for hormone-receptor interaction and antagonist design
    • Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD, Szkudlinski MW 2000 The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 141:3514-3517
    • (2000) Endocrinology , vol.141 , pp. 3514-3517
    • Zhang, M.1    Tong, K.P.2    Fremont, V.3    Chen, J.4    Narayan, P.5    Puett, D.6    Weintraub, B.D.7    Szkudlinski, M.W.8
  • 12
    • 0036214718 scopus 로고    scopus 로고
    • Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist
    • Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S 2002 Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Mol Endocrinol 16:736-746
    • (2002) Mol Endocrinol , vol.16 , pp. 736-746
    • Vlaeminck-Guillem, V.1    Ho, S.C.2    Rodien, P.3    Vassart, G.4    Costagliola, S.5
  • 13
    • 1542316313 scopus 로고    scopus 로고
    • A molecular dissection of the glycoprotein hormone receptors
    • Vassart G, Pardo L, Costagliola S 2004 A molecular dissection of the glycoprotein hormone receptors. Trends Biochem Sci 29:119-126
    • (2004) Trends Biochem Sci , vol.29 , pp. 119-126
    • Vassart, G.1    Pardo, L.2    Costagliola, S.3
  • 14
    • 0037033014 scopus 로고    scopus 로고
    • Structural requirements for mutational lutropin/choriogonadotropin receptor activation
    • Sangkuhl K, Schulz A, Schultz G, Schoneberg T 2002 Structural requirements for mutational lutropin/choriogonadotropin receptor activation. J Biol Chem 277:47748-47755
    • (2002) J Biol Chem , vol.277 , pp. 47748-47755
    • Sangkuhl, K.1    Schulz, A.2    Schultz, G.3    Schoneberg, T.4
  • 15
    • 0037200664 scopus 로고    scopus 로고
    • Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain
    • Jaquette J, Segaloff DL 2002 Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain. Mol Cell Endocrinol 194:211-215
    • (2002) Mol Cell Endocrinol , vol.194 , pp. 211-215
    • Jaquette, J.1    Segaloff, D.L.2
  • 16
    • 0025969701 scopus 로고
    • Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function
    • Nagayama Y, Wadsworth HL, Chazenbalk GD, Russo D, Seto P, Rapoport B 1991 Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. Proc Natl Acad Sci USA 88:902-905
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 902-905
    • Nagayama, Y.1    Wadsworth, H.L.2    Chazenbalk, G.D.3    Russo, D.4    Seto, P.5    Rapoport, B.6
  • 18
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
    • Seidah NG, Chretien M 1999 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848:45-62
    • (1999) Brain Res , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 20
  • 21
    • 0022512416 scopus 로고
    • Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions
    • Staros JV, Wright RW, Swingle DM 1986 Enhancement by N- hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions. Anal Biochem 156:220-222
    • (1986) Anal Biochem , vol.156 , pp. 220-222
    • Staros, J.V.1    Wright, R.W.2    Swingle, D.M.3
  • 22
    • 0025181840 scopus 로고
    • Zero-length crosslinking procedure with the use of active esters
    • Grabarek Z, Gergely J 1990 Zero-length crosslinking procedure with the use of active esters. Anal Biochem 185:131-135
    • (1990) Anal Biochem , vol.185 , pp. 131-135
    • Grabarek, Z.1    Gergely, J.2
  • 23
    • 0037199930 scopus 로고    scopus 로고
    • A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7
    • Angelova K, Fanelli F, Puett D 2002 A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7. J Biol Chem 277:32202-32213
    • (2002) J Biol Chem , vol.277 , pp. 32202-32213
    • Angelova, K.1    Fanelli, F.2    Puett, D.3
  • 24
    • 0030912536 scopus 로고    scopus 로고
    • A model of the lutropin/choriogonadotropin receptor: Insights into the structural and functional effects of constitutively activating mutations
    • Lin Z, Shenker A, Pearlstein R 1997 A model of the lutropin/ choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations. Protein Eng 10:501-510
    • (1997) Protein Eng , vol.10 , pp. 501-510
    • Lin, Z.1    Shenker, A.2    Pearlstein, R.3
  • 26
    • 0033593464 scopus 로고    scopus 로고
    • Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion
    • Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 1999 Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion. J Biol Chem 274:2093-2096
    • (1999) J Biol Chem , vol.274 , pp. 2093-2096
    • Tanaka, K.1    Chazenbalk, G.D.2    McLachlan, S.M.3    Rapoport, B.4
  • 27
    • 0037775660 scopus 로고    scopus 로고
    • A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineage
    • Gromoll J, Wistuba J, Terwort N, Godmann M, Muller T, Simoni M 2003 A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineage. Biol Reprod 69:75-80
    • (2003) Biol Reprod , vol.69 , pp. 75-80
    • Gromoll, J.1    Wistuba, J.2    Terwort, N.3    Godmann, M.4    Muller, T.5    Simoni, M.6
  • 28
    • 0038368875 scopus 로고    scopus 로고
    • Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action
    • Muller T, Gromoll J, Simoni M 2003 Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action. J Clin Endocrinol Metab 88:2242-2249
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2242-2249
    • Muller, T.1    Gromoll, J.2    Simoni, M.3
  • 29
    • 0027239927 scopus 로고
    • Reconstitution of a high-affinity functional lutropin receptor by coexpression of its extracellular and membrane domains
    • Remy JJ, Bozon V, Couture L, Goxe B, Salesse R, Garnier J 1993 Reconstitution of a high-affinity functional lutropin receptor by coexpression of its extracellular and membrane domains. Biochem Biophys Res Commun 193:1023-1030
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 1023-1030
    • Remy, J.J.1    Bozon, V.2    Couture, L.3    Goxe, B.4    Salesse, R.5    Garnier, J.6
  • 30
    • 0036930082 scopus 로고    scopus 로고
    • Rescue of intracellularly trapped lutropin receptor exodomain by endodomain and reconstitution of a functional membrane receptor: Interaction between exo- and endodomains
    • Bozon V, Couture L, Pajot-Augy E, Richard F, Remy JJ, Salesse R 2002 Rescue of intracellularly trapped lutropin receptor exodomain by endodomain and reconstitution of a functional membrane receptor: interaction between exo- and endodomains. Protein Expr Purif 25:114-123
    • (2002) Protein Expr Purif , vol.25 , pp. 114-123
    • Bozon, V.1    Couture, L.2    Pajot-Augy, E.3    Richard, F.4    Remy, J.J.5    Salesse, R.6
  • 31
    • 0030868842 scopus 로고    scopus 로고
    • Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation
    • Osuga Y, Hayashi M, Kudo M, Conti M, Kobilka B, Hsueh AJ 1997 Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. J Biol Chem 272:25006-25012
    • (1997) J Biol Chem , vol.272 , pp. 25006-25012
    • Osuga, Y.1    Hayashi, M.2    Kudo, M.3    Conti, M.4    Kobilka, B.5    Hsueh, A.J.6
  • 32
    • 0037634482 scopus 로고    scopus 로고
    • Structural analysis of yoked chorionic gonadotropin-luteinizing hormone receptor ectodomain complexes by circular dichroic spectroscopy
    • Fralish GB, Dattilo B, Puett D 2003 Structural analysis of yoked chorionic gonadotropin-luteinizing hormone receptor ectodomain complexes by circular dichroic spectroscopy. Mol Endocrinol 17:1192-1202
    • (2003) Mol Endocrinol , vol.17 , pp. 1192-1202
    • Fralish, G.B.1    Dattilo, B.2    Puett, D.3
  • 33
    • 0029757509 scopus 로고    scopus 로고
    • Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling
    • Bhowmick N, Huang J, Puett D, Isaacs NW, Lapthorn AJ 1996 Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Mol Endocrinol 10:1147-1159
    • (1996) Mol Endocrinol , vol.10 , pp. 1147-1159
    • Bhowmick, N.1    Huang, J.2    Puett, D.3    Isaacs, N.W.4    Lapthorn, A.J.5
  • 34
    • 10944228424 scopus 로고    scopus 로고
    • Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface
    • Kleinau G, Jaschke H, Neumann S, Lattig J, Paschke R, Krause G 2004 Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem 279:51590-51600
    • (2004) J Biol Chem , vol.279 , pp. 51590-51600
    • Kleinau, G.1    Jaschke, H.2    Neumann, S.3    Lattig, J.4    Paschke, R.5    Krause, G.6
  • 35
    • 0037387335 scopus 로고    scopus 로고
    • Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity
    • Chen CR, Chazenbalk GD, McLachlan SM, Rapoport B 2003 Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity. Endocrinology 144:1324-1330
    • (2003) Endocrinology , vol.144 , pp. 1324-1330
    • Chen, C.R.1    Chazenbalk, G.D.2    McLachlan, S.M.3    Rapoport, B.4
  • 36
    • 0030053238 scopus 로고    scopus 로고
    • Shedding of human thyrotropin receptor ectodomain. Involvement of a matrix metalloprotease
    • Couet J, Sar S, Jolivet A, Hai MT, Milgrom E, Misrahi M 1996 Shedding of human thyrotropin receptor ectodomain. Involvement of a matrix metalloprotease. J Biol Chem 271:4545-4552
    • (1996) J Biol Chem , vol.271 , pp. 4545-4552
    • Couet, J.1    Sar, S.2    Jolivet, A.3    Hai, M.T.4    Milgrom, E.5    Misrahi, M.6
  • 37
    • 0035793543 scopus 로고    scopus 로고
    • The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation
    • Zeng H, Phang T, Song YS, Ji I, Ji TH 2001 The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation. J Biol Chem 276:3451-3458
    • (2001) J Biol Chem , vol.276 , pp. 3451-3458
    • Zeng, H.1    Phang, T.2    Song, Y.S.3    Ji, I.4    Ji, T.H.5
  • 38
    • 0037040202 scopus 로고    scopus 로고
    • The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: Studies using chimeric human and fly receptors
    • Nishi S, Nakabayashi K, Kobilka B, Hsueh AJ 2002 The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. J Biol Chem 277:3958-3964
    • (2002) J Biol Chem , vol.277 , pp. 3958-3964
    • Nishi, S.1    Nakabayashi, K.2    Kobilka, B.3    Hsueh, A.J.4
  • 39
    • 0032582817 scopus 로고    scopus 로고
    • High affinity hormone binding to the extracellular N-terminal exodomain of the follicle-stimulating hormone receptor is critically modulated by exoloop 3
    • Ryu K, Gilchrist RL, Tung CS, Ji I, Ji TH 1998 High affinity hormone binding to the extracellular N-terminal exodomain of the follicle-stimulating hormone receptor is critically modulated by exoloop 3. J Biol Chem 273:28953-28958
    • (1998) J Biol Chem , vol.273 , pp. 28953-28958
    • Ryu, K.1    Gilchrist, R.L.2    Tung, C.S.3    Ji, I.4    Ji, T.H.5
  • 40
    • 0029670790 scopus 로고    scopus 로고
    • Lys583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling
    • Fernandez LM, Puett D 1996 Lys583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling. J Biol Chem 271:925-930
    • (1996) J Biol Chem , vol.271 , pp. 925-930
    • Fernandez, L.M.1    Puett, D.2
  • 41
    • 0029979530 scopus 로고    scopus 로고
    • Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor. Lys583 is essential and irreplaceable for human choriogonadotropin (hCG)-dependent receptor activation but not for high affinity hCG binding
    • Ryu KS, Gilchrist RL, Ji I, Kim SJ, Ji TH 1996 Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor. Lys583 is essential and irreplaceable for human choriogonadotropin (hCG)-dependent receptor activation but not for high affinity hCG binding. J Biol Chem 271:7301-7304
    • (1996) J Biol Chem , vol.271 , pp. 7301-7304
    • Ryu, K.S.1    Gilchrist, R.L.2    Ji, I.3    Kim, S.J.4    Ji, T.H.5
  • 42
    • 0027385348 scopus 로고
    • Receptor activation is distinct from hormone binding in intact lutropin-choriogonadotropin receptors and Asp397 is important for receptor activation
    • Ji I, Ji TH 1993 Receptor activation is distinct from hormone binding in intact lutropin-choriogonadotropin receptors and Asp397 is important for receptor activation. J Biol Chem 268:20851-20854
    • (1993) J Biol Chem , vol.268 , pp. 20851-20854
    • Ji, I.1    Ji, T.H.2
  • 43
    • 85047686522 scopus 로고    scopus 로고
    • cis- And trans-activation of hormone receptors: The LH receptor
    • Ji I, Lee C, Song Y, Conn PM, Ji TH 2002 cis- And trans-activation of hormone receptors: the LH receptor. Mol Endocrinol 16:1299-1308
    • (2002) Mol Endocrinol , vol.16 , pp. 1299-1308
    • Ji, I.1    Lee, C.2    Song, Y.3    Conn, P.M.4    Ji, T.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.