메뉴 건너뛰기




Volumn 38, Issue 1-2, 2007, Pages 259-275

A conformational contribution of the luteinizing hormone-receptor ectodomain to receptor activation

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; CYCLIC AMP; HYBRID PROTEIN; LUTEINIZING HORMONE RECEPTOR; THYROTROPIN RECEPTOR;

EID: 33847644034     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.02160     Document Type: Article
Times cited : (24)

References (51)
  • 1
    • 0033054119 scopus 로고    scopus 로고
    • Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling
    • Alvarez CA, Narayan P, Huang J & Puett D 1999 Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling. Endocrinology 140 1775-1782.
    • (1999) Endocrinology , vol.140 , pp. 1775-1782
    • Alvarez, C.A.1    Narayan, P.2    Huang, J.3    Puett, D.4
  • 2
    • 0036217072 scopus 로고    scopus 로고
    • The lutropin/choriogonadotropin receptor, a 2002 perspective
    • Ascoli M, Fanelli F & Segaloff DL 2002 The lutropin /choriogonadotropin receptor, a 2002 perspective. Endocrine Reviews 23 141-174.
    • (2002) Endocrine Reviews , vol.23 , pp. 141-174
    • Ascoli, M.1    Fanelli, F.2    Segaloff, D.L.3
  • 3
    • 1342332980 scopus 로고    scopus 로고
    • Single chain variants of the glycoprotein hormones and their receptors as tools to study receptor activation and for analogue design
    • Ben-Menahem D 2004 Single chain variants of the glycoprotein hormones and their receptors as tools to study receptor activation and for analogue design. Journal of Neuroendocrinology 16 171-177.
    • (2004) Journal of Neuroendocrinology , vol.16 , pp. 171-177
    • Ben-Menahem, D.1
  • 4
    • 0029757509 scopus 로고    scopus 로고
    • Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling
    • Bhowmick N, Huang J, Puett D, Isaacs NW & Lapthorn AJ 1996 Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology 10 1147-1159.
    • (1996) Molecular Endocrinology , vol.10 , pp. 1147-1159
    • Bhowmick, N.1    Huang, J.2    Puett, D.3    Isaacs, N.W.4    Lapthorn, A.J.5
  • 6
    • 0031790855 scopus 로고    scopus 로고
    • A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling
    • Biebermann H, Schoneberg T, Schulz A, Krause G, Gruters A, Schultz G & Gudermann T 1998 A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling. FASEB Journal 12 1461-1471.
    • (1998) FASEB Journal , vol.12 , pp. 1461-1471
    • Biebermann, H.1    Schoneberg, T.2    Schulz, A.3    Krause, G.4    Gruters, A.5    Schultz, G.6    Gudermann, T.7
  • 7
    • 0025847496 scopus 로고
    • Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity
    • Braun T, Schofield PR & Sprengel R 1991 Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. EMBO Journal 10 1885-1890.
    • (1991) EMBO Journal , vol.10 , pp. 1885-1890
    • Braun, T.1    Schofield, P.R.2    Sprengel, R.3
  • 8
    • 0030068064 scopus 로고    scopus 로고
    • Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors
    • Cetani F, Tonacchera M & Vassart G 1996 Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors. FEBS Letters 378 27-31.
    • (1996) FEBS Letters , vol.378 , pp. 27-31
    • Cetani, F.1    Tonacchera, M.2    Vassart, G.3
  • 9
    • 0029910563 scopus 로고    scopus 로고
    • A defined epitope on the human choriogonadotropin alpha-subunit interacts with the second extracellular loop of the transmembrane domain of the lutropin/choriogonadotropin receptor
    • Couture L, Remy JJ, Rabesona H, Troalen F, Pajot-Augy E, Bozon V, Haertle T, Bidart JM & Salesse R 1996 A defined epitope on the human choriogonadotropin alpha-subunit interacts with the second extracellular loop of the transmembrane domain of the lutropin/choriogonadotropin receptor. European Journal of Biochemistry 241 627-632.
    • (1996) European Journal of Biochemistry , vol.241 , pp. 627-632
    • Couture, L.1    Remy, J.J.2    Rabesona, H.3    Troalen, F.4    Pajot-Augy, E.5    Bozon, V.6    Haertle, T.7    Bidart, J.M.8    Salesse, R.9
  • 10
    • 12744280744 scopus 로고    scopus 로고
    • Structure of human follicle-stimulating hormone in complex with its receptor
    • Fan QR & Hendrickson WA 2005 Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433 269-277.
    • (2005) Nature , vol.433 , pp. 269-277
    • Fan, Q.R.1    Hendrickson, W.A.2
  • 11
    • 0036773467 scopus 로고    scopus 로고
    • Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions
    • Garcia-Campayo V, Kumar TR & Boime I 2002 Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions. Endocrinology 143 3773-3778.
    • (2002) Endocrinology , vol.143 , pp. 3773-3778
    • Garcia-Campayo, V.1    Kumar, T.R.2    Boime, I.3
  • 12
    • 7244250222 scopus 로고    scopus 로고
    • A single-chain bifunctional gonadotropin analog is secreted from Chinese hamster ovary cells as two distinct bioactive species
    • Garcia-Campayo V, Jablonka-Shariff A & Boime I 2004 A single-chain bifunctional gonadotropin analog is secreted from Chinese hamster ovary cells as two distinct bioactive species. Journal of Biological Chemistry 279 44286-44293.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 44286-44293
    • Garcia-Campayo, V.1    Jablonka-Shariff, A.2    Boime, I.3
  • 14
  • 15
    • 7044252982 scopus 로고    scopus 로고
    • Molecular characterization of a new leucine-rich repeat-containing G protein-coupled receptor from a bivalve mollusc: Evolutionary implications
    • Herpin A, Badariotti F, Rodet F & Favrel P 2004 Molecular characterization of a new leucine-rich repeat-containing G protein-coupled receptor from a bivalve mollusc: evolutionary implications. Biochimica et Biophysica Acta 1680 137-144.
    • (2004) Biochimica Et Biophysica Acta , vol.1680 , pp. 137-144
    • Herpin, A.1    Badariotti, F.2    Rodet, F.3    Favrel, P.4
  • 16
    • 0032577468 scopus 로고    scopus 로고
    • The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. I. Mutational analysis
    • Hong S, Phang T, Ji I & Ji TH 1998 The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. I. Mutational analysis. Journal of Biological Chemistry 273 13835-13840.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 13835-13840
    • Hong, S.1    Phang, T.2    Ji, I.3    Ji, T.H.4
  • 17
    • 0033279171 scopus 로고    scopus 로고
    • The alpha-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/choriogonadotropin receptor
    • Hong S, Ji I & Ji TH 1999a The alpha-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/ choriogonadotropin receptor. Endocrinology 140 2486-2493.
    • (1999) Endocrinology , vol.140 , pp. 2486-2493
    • Hong, S.1    Ji, I.2    Ji, T.H.3
  • 18
    • 0033304617 scopus 로고    scopus 로고
    • The beta-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/choriogonadotropin receptor and changes its interaction with the alpha-subunit
    • Hong SH, Ji IH & Ji TH 1999b The beta-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/choriogonadotropin receptor and changes its interaction with the alpha-subunit. Molecular Endocrinology 13 1285-1294.
    • (1999) Molecular Endocrinology , vol.13 , pp. 1285-1294
    • Hong, S.H.1    Ji, I.H.2    Ji, T.H.3
  • 19
    • 0034464024 scopus 로고    scopus 로고
    • The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): Identification of LGR6 and LGR7 and the signaling mechanism for LGR7
    • Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M & Hsueh AJ 2000 The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Molecular Endocrinology 14 1257-1271.
    • (2000) Molecular Endocrinology , vol.14 , pp. 1257-1271
    • Hsu, S.Y.1    Kudo, M.2    Chen, T.3    Nakabayashi, K.4    Bhalla, A.5    van der Spek, P.J.6    van Duin, M.7    Hsueh, A.J.8
  • 21
    • 0025739241 scopus 로고
    • Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis
    • Ji IH & Ji TH 1991 Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis. Journal of Biological Chemistry 266 13076-13079.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 13076-13079
    • Ji, I.H.1    Ji, T.H.2
  • 22
    • 23744497499 scopus 로고    scopus 로고
    • Zero-length cross-linking reveals that tight interactions between the extracellular and transmembrane domains of the LH receptor persist during receptor activation
    • Karges B, Gidenne S, Aumas C, Haddad F, Kelly PA, Milgrom E & de Roux N 2005 Zero-length cross-linking reveals that tight interactions between the extracellular and transmembrane domains of the LH receptor persist during receptor activation. Molecular Endocrinology 19 2086-2098.
    • (2005) Molecular Endocrinology , vol.19 , pp. 2086-2098
    • Karges, B.1    Gidenne, S.2    Aumas, C.3    Haddad, F.4    Kelly, P.A.5    Milgrom, E.6    de Roux, N.7
  • 23
    • 0029657910 scopus 로고    scopus 로고
    • The role of Asp578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor
    • Kosugi S, Mori T & Shenker A 1996 The role of Asp578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor. Journal of Biological Chemistry 271 31813-31817.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 31813-31817
    • Kosugi, S.1    Mori, T.2    Shenker, A.3
  • 25
    • 17544380552 scopus 로고    scopus 로고
    • Photoaffinity labeling of the lutropin receptor with synthetic peptide for carboxyl terminus of the human choriogonadotropin alpha subunit
    • Kundu GC, Ji I, McCormick DJ & Ji TH 1996 Photoaffinity labeling of the lutropin receptor with synthetic peptide for carboxyl terminus of the human choriogonadotropin alpha subunit. Journal of Biological Chemistry 271 11063-11066.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 11063-11066
    • Kundu, G.C.1    Ji, I.2    McCormick, D.J.3    Ji, T.H.4
  • 27
    • 0028944310 scopus 로고
    • Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty
    • Laue L, Chan WY, Hsueh AJ, Kudo M, Hsu SY, Wu SM, Blomberg L & Cutler GB Jr 1995 Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty. PNAS 92 1906-1910.
    • (1995) PNAS , vol.92 , pp. 1906-1910
    • Laue, L.1    Chan, W.Y.2    Hsueh, A.J.3    Kudo, M.4    Hsu, S.Y.5    Wu, S.M.6    Blomberg, L.7    Cutler Jr., G.B.8
  • 28
  • 30
    • 0031976756 scopus 로고    scopus 로고
    • Severe testotoxicosis phenotype associated with Asp578 → Tyr mutation of the lutrophin/choriogonadotrophin receptor gene
    • Muller J, Gondos B, Kosugi S, Mori T & Shenker A 1998 Severe testotoxicosis phenotype associated with Asp578 → Tyr mutation of the lutrophin/choriogonadotrophin receptor gene. Journal of Medical Genetics 35 340-341.
    • (1998) Journal of Medical Genetics , vol.35 , pp. 340-341
    • Muller, J.1    Gondos, B.2    Kosugi, S.3    Mori, T.4    Shenker, A.5
  • 31
    • 0034730516 scopus 로고    scopus 로고
    • Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region
    • Nakabayashi K, Kudo M, Kobilka B & Hsueh AJ 2000 Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region. Journal of Biological Chemistry 275 30264-30271.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 30264-30271
    • Nakabayashi, K.1    Kudo, M.2    Kobilka, B.3    Hsueh, A.J.4
  • 32
    • 85047681976 scopus 로고    scopus 로고
    • A biologically active single chain human chorionic gonadotropin analog with altered receptor binding properties
    • Narayan P, Gray J & Puett D 2000 A biologically active single chain human chorionic gonadotropin analog with altered receptor binding properties. Endocrinology 141 67-71.
    • (2000) Endocrinology , vol.141 , pp. 67-71
    • Narayan, P.1    Gray, J.2    Puett, D.3
  • 33
    • 0036913852 scopus 로고    scopus 로고
    • Yoked complexes of human choriogonadotropin and the lutropin receptor: Evidence that monomeric individual subunits are inactive
    • Narayan P, Gray J & Puett D 2002 Yoked complexes of human choriogonadotropin and the lutropin receptor: evidence that monomeric individual subunits are inactive. Molecular Endocrinology 16 2733-2745.
    • (2002) Molecular Endocrinology , vol.16 , pp. 2733-2745
    • Narayan, P.1    Gray, J.2    Puett, D.3
  • 34
    • 0037040202 scopus 로고    scopus 로고
    • The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: Studies using chimeric human and fly receptors
    • Nishi S, Nakabayashi K, Kobilka B & Hsuch AJ 2002 The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. Journal of Biological Chemistry 277 3958-3964.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 3958-3964
    • Nishi, S.1    Nakabayashi, K.2    Kobilka, B.3    Hsuch, A.J.4
  • 35
    • 0032577706 scopus 로고    scopus 로고
    • The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. II. Photoaffinity labeling
    • Phang T, Kundu G, Hong S, Ji I & Ji TH 1998 The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. II. Photoaffinity labeling. Journal of Biological Chemistry 273 13841-13847.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 13841-13847
    • Phang, T.1    Kundu, G.2    Hong, S.3    Ji, I.4    Ji, T.H.5
  • 38
    • 0037033014 scopus 로고    scopus 로고
    • Structural requirements for mutational lutropin/choriogonadotropin receptor activation
    • Sangkuhl K, Schulz A, Schultz G & Schoneberg T 2002 Structural requirements for mutational lutropin/choriogonadotropin receptor activation. Journal of Biological Chemistry 277 47748-47755.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 47748-47755
    • Sangkuhl, K.1    Schulz, A.2    Schultz, G.3    Schoneberg, T.4
  • 39
    • 0041138283 scopus 로고    scopus 로고
    • Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication
    • Schoneberg T, Sandig V, Wess J, Gudermann T & Schultz G 1997 Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication. Journal of Clinical Investigation 100 1547-1556.
    • (1997) Journal of Clinical Investigation , vol.100 , pp. 1547-1556
    • Schoneberg, T.1    Sandig, V.2    Wess, J.3    Gudermann, T.4    Schultz, G.5
  • 42
    • 0028948846 scopus 로고
    • Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem
    • Sugahara T, Pixley MR, Minami S, Perlas E, Ben-Menahem D, Hsueh AJ & Boime I 1995 Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem. PNAS 92 2041-2045.
    • (1995) PNAS , vol.92 , pp. 2041-2045
    • Sugahara, T.1    Pixley, M.R.2    Minami, S.3    Perlas, E.4    Ben-Menahem, D.5    Hsueh, A.J.6    Boime, I.7
  • 43
    • 0029948074 scopus 로고    scopus 로고
    • Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadortropin receptor suggest leucine-rich repeats 1-6 are involved in hormone binding
    • Thomas D, Rozell TG, Liu X & Segaloff DL 1996 Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadortropin receptor suggest leucine-rich repeats 1-6 are involved in hormone binding. Molecular Endocrinology 10 760-768.
    • (1996) Molecular Endocrinology , vol.10 , pp. 760-768
    • Thomas, D.1    Rozell, T.G.2    Liu, X.3    Segaloff, D.L.4
  • 46
    • 0036214718 scopus 로고    scopus 로고
    • Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist
    • Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G & Costagliola S 2002 Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Molecular Endocrinology 16 736-746.
    • (2002) Molecular Endocrinology , vol.16 , pp. 736-746
    • Vlaeminck-Guillem, V.1    Ho, S.C.2    Rodien, P.3    Vassart, G.4    Costagliola, S.5
  • 47
    • 0025646717 scopus 로고
    • Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity
    • Xie YB, Wang H & Segaloff DL 1990 Extracellular domain of lutropin/ choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. Journal of Biological Chemistry 265 21411-21414.
    • (1990) Journal of Biological Chemistry , vol.265 , pp. 21411-21414
    • Xie, Y.B.1    Wang, H.2    Segaloff, D.L.3
  • 48
    • 0029992481 scopus 로고    scopus 로고
    • A case of male-limited precocious puberty caused by a point mutation in the second transmembrane domain of the luteinizing hormone choriogonadotropin receptor gene
    • Yano K, Kohn LD, Saji M, Kataoka N, Okuno A & Cutler GB Jr 1996 A case of male-limited precocious puberty caused by a point mutation in the second transmembrane domain of the luteinizing hormone choriogonadotropin receptor gene. Biochemical and Biophysical Research Communications 220 1036-1042.
    • (1996) Biochemical and Biophysical Research Communications , vol.220 , pp. 1036-1042
    • Yano, K.1    Kohn, L.D.2    Saji, M.3    Kataoka, N.4    Okuno, A.5    Cutler Jr., G.B.6
  • 49
    • 0029056743 scopus 로고
    • Constitutive activation of the thyrotropin receptor by deletion of a portion of the extracellular domain
    • Zhang ML, Sugawa H, Kosugi S & Mori T 1995 Constitutive activation of the thyrotropin receptor by deletion of a portion of the extracellular domain. Biochemical and Biophysical Research Communications 211 205-210.
    • (1995) Biochemical and Biophysical Research Communications , vol.211 , pp. 205-210
    • Zhang, M.L.1    Sugawa, H.2    Kosugi, S.3    Mori, T.4
  • 50
    • 0034457935 scopus 로고    scopus 로고
    • The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: Implications for hormone-receptor interaction and antagonist design
    • Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD & Szkudlinski MW 2000 The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 141 3514-3517.
    • (2000) Endocrinology , vol.141 , pp. 3514-3517
    • Zhang, M.1    Tong, K.P.2    Fremont, V.3    Chen, J.4    Narayan, P.5    Puett, D.6    Weintraub, B.D.7    Szkudlinski, M.W.8
  • 51
    • 22544468863 scopus 로고    scopus 로고
    • The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor
    • Zhang M, Mizrachi D, Fanelli F & Segaloff DL 2005 The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor. Journal of Biological Chemistry 280 26169-26176.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 26169-26176
    • Zhang, M.1    Mizrachi, D.2    Fanelli, F.3    Segaloff, D.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.